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C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus.
Diabet Med. 2004 Apr; 21(4):336-41.DM

Abstract

AIMS

To compare the importance of different inflammatory markers and traditional risk factors in predicting peripheral vascular disease (PVD) in patients with Type 2 diabetes mellitus.

METHODS

A cross-sectional analysis of 30 Type 2 diabetic patients with PVD defined by ankle-brachial index (ABI) < 0.9, and 60 Type 2 diabetic patients without PVD (ABI > 1.0). Overnight blood was drawn and sent for study.

RESULTS

Longer diabetic duration (15 +/- 8 vs. 10 +/- 7 years, P = 0.007), higher serum creatinine level (0.11 +/- 0.04 vs. 0.09 +/- 0.03 mmol/l, P = 0.001), higher total cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio (5.2 +/- 1.6 vs. 4.3 +/- 1.1, P = 0.004) and increased hypertension status (70% vs. 52%, P = 0.014) and cerebral infarction (CI) history (23% vs. 3%, P = 0.009) were noted in Type 2 diabetes with PVD. Those with PVD also showed significantly higher serum levels of C-reactive protein (CRP) (median 0.282 vs. 0.102 mg/dl, P < 0.001) and interleukin (IL)-6 (10.6 +/- 1.81 vs 1.6 +/- 4.6 pg/ml, P = 0.001). Multivariate regression analysis showed that higher serum levels of C-reactive protein (CRP), longer diabetic duration, and use of angiotensin converting enzyme inhibitor (ACEI) were independently associated with PVD in Type 2 diabetes mellitus.

CONCLUSIONS

Type 2 diabetic patients with PVD had longer diabetic duration, higher serum creatinine levels, higher TC/HDL-C ratio, higher hypertension and CI history and higher CRP and IL-6 levels. Only serum CRP level, diabetic duration, and use of ACEI were independently associated with PVD in Type 2 diabetes mellitus.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiway, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15049935

Citation

Yu, H-I, et al. "C-reactive Protein and Risk Factors for Peripheral Vascular Disease in Subjects With Type 2 Diabetes Mellitus." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 21, no. 4, 2004, pp. 336-41.
Yu HI, Sheu WH, Song YM, et al. C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. Diabet Med. 2004;21(4):336-41.
Yu, H. I., Sheu, W. H., Song, Y. M., Liu, H. C., Lee, W. J., & Chen, Y. T. (2004). C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association, 21(4), 336-41.
Yu HI, et al. C-reactive Protein and Risk Factors for Peripheral Vascular Disease in Subjects With Type 2 Diabetes Mellitus. Diabet Med. 2004;21(4):336-41. PubMed PMID: 15049935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. AU - Yu,H-I, AU - Sheu,W H-H, AU - Song,Y-M, AU - Liu,H-C, AU - Lee,W-J, AU - Chen,Y-T, PY - 2004/3/31/pubmed PY - 2004/7/1/medline PY - 2004/3/31/entrez SP - 336 EP - 41 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 21 IS - 4 N2 - AIMS: To compare the importance of different inflammatory markers and traditional risk factors in predicting peripheral vascular disease (PVD) in patients with Type 2 diabetes mellitus. METHODS: A cross-sectional analysis of 30 Type 2 diabetic patients with PVD defined by ankle-brachial index (ABI) < 0.9, and 60 Type 2 diabetic patients without PVD (ABI > 1.0). Overnight blood was drawn and sent for study. RESULTS: Longer diabetic duration (15 +/- 8 vs. 10 +/- 7 years, P = 0.007), higher serum creatinine level (0.11 +/- 0.04 vs. 0.09 +/- 0.03 mmol/l, P = 0.001), higher total cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio (5.2 +/- 1.6 vs. 4.3 +/- 1.1, P = 0.004) and increased hypertension status (70% vs. 52%, P = 0.014) and cerebral infarction (CI) history (23% vs. 3%, P = 0.009) were noted in Type 2 diabetes with PVD. Those with PVD also showed significantly higher serum levels of C-reactive protein (CRP) (median 0.282 vs. 0.102 mg/dl, P < 0.001) and interleukin (IL)-6 (10.6 +/- 1.81 vs 1.6 +/- 4.6 pg/ml, P = 0.001). Multivariate regression analysis showed that higher serum levels of C-reactive protein (CRP), longer diabetic duration, and use of angiotensin converting enzyme inhibitor (ACEI) were independently associated with PVD in Type 2 diabetes mellitus. CONCLUSIONS: Type 2 diabetic patients with PVD had longer diabetic duration, higher serum creatinine levels, higher TC/HDL-C ratio, higher hypertension and CI history and higher CRP and IL-6 levels. Only serum CRP level, diabetic duration, and use of ACEI were independently associated with PVD in Type 2 diabetes mellitus. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15049935/C_reactive_protein_and_risk_factors_for_peripheral_vascular_disease_in_subjects_with_Type_2_diabetes_mellitus_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=15049935.ui DB - PRIME DP - Unbound Medicine ER -