Tags

Type your tag names separated by a space and hit enter

Gender variation in PTH sensitivity and rhythmicity following growth hormone replacement in adult growth hormone-deficient patients.
Clin Endocrinol (Oxf). 2004 Apr; 60(4):516-26.CE

Abstract

BACKGROUND

Adult GH deficiency (AGHD) is associated with osteoporosis and reduced bone turnover; factors improved by GH replacement (GHR), with men gaining greater benefit than women. Reduction in sensitivity of bone and kidney to the effects of PTH may underlie AGHD changes in bone turnover. We determined the gender difference in PTH target-organ sensitivity following GHR in AGHD patients.

DESIGN, PATIENTS AND MEASUREMENTS

Twenty AGHD patients (10 men) were admitted to hospital before and after GHR initiation. Half-hourly blood samples were collected for PTH, calcium, nephrogenous cyclic AMP (NcAMP, marker of PTH activity), type-I collagen C-telopeptide (CTX, bone resorption marker) and procollagen type-I amino-terminal propeptide (PINP, bone formation marker).

RESULTS

The 24-h mean PTH concentration decreased in both genders (P < 0.001), with maximal changes seen 6 and 12 months following GHR in men and women, respectively. Increases in 24-h mean NcAMP (P < 0.05), calcium (P < 0.001) and bone turnover markers (P < 0.001) occurred in both genders following GHR, with maximal changes at 1 month in men, but at 3 months for NcAMP, calcium and CTX and 12 months for PINP in women. Maximal NcAMP increase was higher in men (P = 0.009).

CONCLUSIONS

Following GHR, PTH target-organ sensitivity increased in both genders, demonstrated by simultaneous reduction in PTH concentration and increase in NcAMP, calcium and bone turnover. In women, improvement in renal PTH sensitivity was delayed and reduced, and changes in bone turnover were delayed, with increase in bone resorption preceding bone formation. Both factors may contribute to the reduced bone mineral density (BMD) response to GHR observed in women.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, Royal Liverpool Hospital, Liverpool, UK. h.white@ukf.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15049968

Citation

White, H D., et al. "Gender Variation in PTH Sensitivity and Rhythmicity Following Growth Hormone Replacement in Adult Growth Hormone-deficient Patients." Clinical Endocrinology, vol. 60, no. 4, 2004, pp. 516-26.
White HD, Ahmad AM, Syed AA, et al. Gender variation in PTH sensitivity and rhythmicity following growth hormone replacement in adult growth hormone-deficient patients. Clin Endocrinol (Oxf). 2004;60(4):516-26.
White, H. D., Ahmad, A. M., Syed, A. A., Clewes, A., Peter, R., Vora, J. P., & Fraser, W. D. (2004). Gender variation in PTH sensitivity and rhythmicity following growth hormone replacement in adult growth hormone-deficient patients. Clinical Endocrinology, 60(4), 516-26.
White HD, et al. Gender Variation in PTH Sensitivity and Rhythmicity Following Growth Hormone Replacement in Adult Growth Hormone-deficient Patients. Clin Endocrinol (Oxf). 2004;60(4):516-26. PubMed PMID: 15049968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender variation in PTH sensitivity and rhythmicity following growth hormone replacement in adult growth hormone-deficient patients. AU - White,H D, AU - Ahmad,A M, AU - Syed,A A, AU - Clewes,A, AU - Peter,R, AU - Vora,J P, AU - Fraser,W D, PY - 2004/3/31/pubmed PY - 2004/6/24/medline PY - 2004/3/31/entrez SP - 516 EP - 26 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 60 IS - 4 N2 - BACKGROUND: Adult GH deficiency (AGHD) is associated with osteoporosis and reduced bone turnover; factors improved by GH replacement (GHR), with men gaining greater benefit than women. Reduction in sensitivity of bone and kidney to the effects of PTH may underlie AGHD changes in bone turnover. We determined the gender difference in PTH target-organ sensitivity following GHR in AGHD patients. DESIGN, PATIENTS AND MEASUREMENTS: Twenty AGHD patients (10 men) were admitted to hospital before and after GHR initiation. Half-hourly blood samples were collected for PTH, calcium, nephrogenous cyclic AMP (NcAMP, marker of PTH activity), type-I collagen C-telopeptide (CTX, bone resorption marker) and procollagen type-I amino-terminal propeptide (PINP, bone formation marker). RESULTS: The 24-h mean PTH concentration decreased in both genders (P < 0.001), with maximal changes seen 6 and 12 months following GHR in men and women, respectively. Increases in 24-h mean NcAMP (P < 0.05), calcium (P < 0.001) and bone turnover markers (P < 0.001) occurred in both genders following GHR, with maximal changes at 1 month in men, but at 3 months for NcAMP, calcium and CTX and 12 months for PINP in women. Maximal NcAMP increase was higher in men (P = 0.009). CONCLUSIONS: Following GHR, PTH target-organ sensitivity increased in both genders, demonstrated by simultaneous reduction in PTH concentration and increase in NcAMP, calcium and bone turnover. In women, improvement in renal PTH sensitivity was delayed and reduced, and changes in bone turnover were delayed, with increase in bone resorption preceding bone formation. Both factors may contribute to the reduced bone mineral density (BMD) response to GHR observed in women. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15049968/Gender_variation_in_PTH_sensitivity_and_rhythmicity_following_growth_hormone_replacement_in_adult_growth_hormone_deficient_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2004&amp;volume=60&amp;issue=4&amp;spage=516 DB - PRIME DP - Unbound Medicine ER -