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Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces.
Neuroimage. 2004 Apr; 21(4):1215-23.N

Abstract

Previous functional neuroimaging studies have demonstrated that the amygdala activates in response to fearful faces presented below the threshold of conscious visual perception. Using a backward masking procedure similar to that of previous studies, we used functional magnetic resonance imaging (fMRI) to study the amygdala and anterior cingulate gyrus during preattentive presentations of sad and happy facial affect. Twelve healthy adult females underwent blood oxygen level dependent (BOLD) fMRI while viewing sad and happy faces, each presented for 20 ms and "masked" immediately by a neutral face for 100 ms. Masked happy faces were associated with significant bilateral activation within the anterior cingulate gyrus and amygdala, whereas masked sadness yielded only limited activation within the left anterior cingulate gyrus. In a direct comparison, masked happy faces yielded significantly greater activation in the anterior cingulate and amygdala relative to identically masked sad faces. Conjunction analysis showed that masked affect perception, regardless of emotional valence, was associated with greater activation within the left amygdala and left anterior cingulate. Findings suggest that the amygdala and anterior cingulate are important components of a network involved in detecting and discriminating affective information presented below the normal threshold of conscious visual perception.

Authors+Show Affiliations

Killgore WD
Cognitive Neuroimaging Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA. william.d.killgore@us.army.mil
Yurgelun-Todd DA
No affiliation info available

MeSH

AdultAmygdalaAwarenessBrain MappingCerebral CortexDiscrimination LearningDominance, CerebralEmotionsFacial ExpressionFemaleGyrus CinguliHappinessHumansImage EnhancementImage Processing, Computer-AssistedLimbic SystemMagnetic Resonance ImagingNerve NetOxygenPattern Recognition, VisualPerceptual MaskingReaction TimeReference ValuesSensory ThresholdsSubliminal Stimulation

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15050549

Citation

Killgore, William D S., and Deborah A. Yurgelun-Todd. "Activation of the Amygdala and Anterior Cingulate During Nonconscious Processing of Sad Versus Happy Faces." NeuroImage, vol. 21, no. 4, 2004, pp. 1215-23.
Killgore WD, Yurgelun-Todd DA. Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. Neuroimage. 2004;21(4):1215-23.
Killgore, W. D., & Yurgelun-Todd, D. A. (2004). Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. NeuroImage, 21(4), 1215-23.
Killgore WD, Yurgelun-Todd DA. Activation of the Amygdala and Anterior Cingulate During Nonconscious Processing of Sad Versus Happy Faces. Neuroimage. 2004;21(4):1215-23. PubMed PMID: 15050549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. AU - Killgore,William D S, AU - Yurgelun-Todd,Deborah A, PY - 2003/04/29/received PY - 2003/12/24/revised PY - 2003/12/30/accepted PY - 2004/3/31/pubmed PY - 2004/8/7/medline PY - 2004/3/31/entrez SP - 1215 EP - 23 JF - NeuroImage JO - Neuroimage VL - 21 IS - 4 N2 - Previous functional neuroimaging studies have demonstrated that the amygdala activates in response to fearful faces presented below the threshold of conscious visual perception. Using a backward masking procedure similar to that of previous studies, we used functional magnetic resonance imaging (fMRI) to study the amygdala and anterior cingulate gyrus during preattentive presentations of sad and happy facial affect. Twelve healthy adult females underwent blood oxygen level dependent (BOLD) fMRI while viewing sad and happy faces, each presented for 20 ms and "masked" immediately by a neutral face for 100 ms. Masked happy faces were associated with significant bilateral activation within the anterior cingulate gyrus and amygdala, whereas masked sadness yielded only limited activation within the left anterior cingulate gyrus. In a direct comparison, masked happy faces yielded significantly greater activation in the anterior cingulate and amygdala relative to identically masked sad faces. Conjunction analysis showed that masked affect perception, regardless of emotional valence, was associated with greater activation within the left amygdala and left anterior cingulate. Findings suggest that the amygdala and anterior cingulate are important components of a network involved in detecting and discriminating affective information presented below the normal threshold of conscious visual perception. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/15050549/Activation_of_the_amygdala_and_anterior_cingulate_during_nonconscious_processing_of_sad_versus_happy_faces_ DB - PRIME DP - Unbound Medicine ER -