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Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys.
Bone. 2004 Apr; 34(4):755-64.BONE

Abstract

Exercise during growth has a positive influence on bone mineral accrual, yet little is known about how bone geometry and strength adapt to loading during growth. Our primary objective was to compare changes in proximal femur bone geometry and strength between 31 prepubertal (Tanner Stage 1) boys who participated in a school-based, high-impact circuit intervention (12 min, three times a week) for 20 months and 33 maturity-matched controls. Our secondary objective was to compare changes in total body (TB), proximal femur (PF), and lumbar spine (LS) bone mineral content (BMC) and bone area (BA) in these groups. We assessed geometric variables and bone strength at the narrow neck (NN), intertrochanteric (TR) region, and femoral shaft regions by applying the Hip Structure Analysis program to proximal femur dual energy X-ray absorptiometry scans (DXA, Hologic QDR 4500). Further, we assessed total body, lumbar spine, and proximal femur BMC and BA by DXA and derived total body lean mass and fat mass from total body scans. Intervention (10.2 +/- 0.5 years) and control boys (10.1 +/- 0.5 years) had similar baseline height (140.8 vs. 141.3 cm) and weight (36.9 vs. 35.4 kg), and average 20-month physical activity scores (Physical Activity Questionnaire for Children, PAQ-C) and calcium intakes (861 vs. 852 mg/day, food frequency questionnaire). Twenty-month height and weight changes were not significantly different between groups; lean mass changed more (P < 0.05) in intervention boys (22.8%) than control boys (18.6%). At the NN region, intervention boys had greater bone expansion on both the periosteal (+2.6%, P = 0.1) and endosteal (+2.7%, P = 0.2) surfaces, resulting in significantly greater changes in section modulus (bone bending strength) (+7.5%, P = 0.02, ANCOVA, adjusting for height change, final Tanner Stage, and baseline bone values). Changes at the intertrochanteric and femoral shaft regions were not significantly different between groups. Femoral neck (FN) BMC changes were significantly greater in intervention boys (+4.3%, P < 0.01); changes in BA and BMC for other regions were not significantly different between groups. In summary, a school-based, high-impact exercise intervention implemented three times a week for 12 min is an effective strategy for site-specific gains in bone strength at the narrow neck region of the proximal femur.

Authors+Show Affiliations

BC Children's Hospital and Food, Nutrition and Health, University of British Columbia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15050908

Citation

MacKelvie, Kerry J., et al. "Bone Mass and Structure Are Enhanced Following a 2-year Randomized Controlled Trial of Exercise in Prepubertal Boys." Bone, vol. 34, no. 4, 2004, pp. 755-64.
MacKelvie KJ, Petit MA, Khan KM, et al. Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone. 2004;34(4):755-64.
MacKelvie, K. J., Petit, M. A., Khan, K. M., Beck, T. J., & McKay, H. A. (2004). Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone, 34(4), 755-64.
MacKelvie KJ, et al. Bone Mass and Structure Are Enhanced Following a 2-year Randomized Controlled Trial of Exercise in Prepubertal Boys. Bone. 2004;34(4):755-64. PubMed PMID: 15050908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. AU - MacKelvie,Kerry J, AU - Petit,Moira A, AU - Khan,Karim M, AU - Beck,Thomas J, AU - McKay,Heather A, PY - 2003/11/12/received PY - 2003/12/12/revised PY - 2003/12/15/accepted PY - 2004/3/31/pubmed PY - 2004/12/23/medline PY - 2004/3/31/entrez SP - 755 EP - 64 JF - Bone JO - Bone VL - 34 IS - 4 N2 - Exercise during growth has a positive influence on bone mineral accrual, yet little is known about how bone geometry and strength adapt to loading during growth. Our primary objective was to compare changes in proximal femur bone geometry and strength between 31 prepubertal (Tanner Stage 1) boys who participated in a school-based, high-impact circuit intervention (12 min, three times a week) for 20 months and 33 maturity-matched controls. Our secondary objective was to compare changes in total body (TB), proximal femur (PF), and lumbar spine (LS) bone mineral content (BMC) and bone area (BA) in these groups. We assessed geometric variables and bone strength at the narrow neck (NN), intertrochanteric (TR) region, and femoral shaft regions by applying the Hip Structure Analysis program to proximal femur dual energy X-ray absorptiometry scans (DXA, Hologic QDR 4500). Further, we assessed total body, lumbar spine, and proximal femur BMC and BA by DXA and derived total body lean mass and fat mass from total body scans. Intervention (10.2 +/- 0.5 years) and control boys (10.1 +/- 0.5 years) had similar baseline height (140.8 vs. 141.3 cm) and weight (36.9 vs. 35.4 kg), and average 20-month physical activity scores (Physical Activity Questionnaire for Children, PAQ-C) and calcium intakes (861 vs. 852 mg/day, food frequency questionnaire). Twenty-month height and weight changes were not significantly different between groups; lean mass changed more (P < 0.05) in intervention boys (22.8%) than control boys (18.6%). At the NN region, intervention boys had greater bone expansion on both the periosteal (+2.6%, P = 0.1) and endosteal (+2.7%, P = 0.2) surfaces, resulting in significantly greater changes in section modulus (bone bending strength) (+7.5%, P = 0.02, ANCOVA, adjusting for height change, final Tanner Stage, and baseline bone values). Changes at the intertrochanteric and femoral shaft regions were not significantly different between groups. Femoral neck (FN) BMC changes were significantly greater in intervention boys (+4.3%, P < 0.01); changes in BA and BMC for other regions were not significantly different between groups. In summary, a school-based, high-impact exercise intervention implemented three times a week for 12 min is an effective strategy for site-specific gains in bone strength at the narrow neck region of the proximal femur. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/15050908/Bone_mass_and_structure_are_enhanced_following_a_2_year_randomized_controlled_trial_of_exercise_in_prepubertal_boys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S875632820300471X DB - PRIME DP - Unbound Medicine ER -