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Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities.
Am J Clin Nutr. 2004 Apr; 79(4):564-9.AJ

Abstract

BACKGROUND

Dietary medium-chain fatty acids (MCFAs) are of nutritional interest because they are more easily absorbed from dietary medium-chain triacylglycerols (MCTs) than are long-chain fatty acids from, for example, vegetable oils. It has generally been claimed that MCFAs do not increase plasma cholesterol, although this claim is poorly documented.

OBJECTIVE

We compared the effects of a diet rich in either MCFAs or oleic acid on fasting blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities in healthy men.

DESIGN

In a study with a double-blind, randomized, crossover design, 17 healthy young men replaced part of their habitual dietary fat intake with 70 g MCTs (66% 8:0 and 34% 10:0) or high-oleic sunflower oil (89.4% 18:1). Each intervention period lasted 21 d, and the 2 periods were separated by a washout period of 2 wk. Blood samples were taken before and after the intervention periods.

RESULTS

Compared with the intake of high-oleic sunflower oil, MCT intake resulted in 11% higher plasma total cholesterol (P = 0.0005), 12% higher LDL cholesterol (P = 0.0001), 32% higher VLDL cholesterol (P = 0.080), a 12% higher ratio of LDL to HDL cholesterol (P = 0.002), 22% higher plasma total triacylglycerol (P = 0.0361), and higher plasma glucose (P = 0.033). Plasma HDL-cholesterol and insulin concentrations and activities of cholesterol ester transfer protein and phospholipid transfer protein did not differ significantly between the diets.

CONCLUSIONS

Compared with fat high in oleic acid, MCT fat unfavorably affected lipid profiles in healthy young men by increasing plasma LDL cholesterol and triacylglycerol. No changes in the activities of phospholipid transfer protein and cholesterol ester transfer protein were evident.

Authors+Show Affiliations

Research Department of Human Nutrition, Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. tine.tholstrup@fhe.kvl.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15051598

Citation

Tholstrup, Tine, et al. "Effects of Medium-chain Fatty Acids and Oleic Acid On Blood Lipids, Lipoproteins, Glucose, Insulin, and Lipid Transfer Protein Activities." The American Journal of Clinical Nutrition, vol. 79, no. 4, 2004, pp. 564-9.
Tholstrup T, Ehnholm C, Jauhiainen M, et al. Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities. Am J Clin Nutr. 2004;79(4):564-9.
Tholstrup, T., Ehnholm, C., Jauhiainen, M., Petersen, M., Høy, C. E., Lund, P., & Sandström, B. (2004). Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities. The American Journal of Clinical Nutrition, 79(4), 564-9.
Tholstrup T, et al. Effects of Medium-chain Fatty Acids and Oleic Acid On Blood Lipids, Lipoproteins, Glucose, Insulin, and Lipid Transfer Protein Activities. Am J Clin Nutr. 2004;79(4):564-9. PubMed PMID: 15051598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities. AU - Tholstrup,Tine, AU - Ehnholm,Christian, AU - Jauhiainen,Matti, AU - Petersen,Martin, AU - Høy,Carl-Erik, AU - Lund,Pia, AU - Sandström,Brittmarie, PY - 2004/3/31/pubmed PY - 2004/4/28/medline PY - 2004/3/31/entrez SP - 564 EP - 9 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 79 IS - 4 N2 - BACKGROUND: Dietary medium-chain fatty acids (MCFAs) are of nutritional interest because they are more easily absorbed from dietary medium-chain triacylglycerols (MCTs) than are long-chain fatty acids from, for example, vegetable oils. It has generally been claimed that MCFAs do not increase plasma cholesterol, although this claim is poorly documented. OBJECTIVE: We compared the effects of a diet rich in either MCFAs or oleic acid on fasting blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities in healthy men. DESIGN: In a study with a double-blind, randomized, crossover design, 17 healthy young men replaced part of their habitual dietary fat intake with 70 g MCTs (66% 8:0 and 34% 10:0) or high-oleic sunflower oil (89.4% 18:1). Each intervention period lasted 21 d, and the 2 periods were separated by a washout period of 2 wk. Blood samples were taken before and after the intervention periods. RESULTS: Compared with the intake of high-oleic sunflower oil, MCT intake resulted in 11% higher plasma total cholesterol (P = 0.0005), 12% higher LDL cholesterol (P = 0.0001), 32% higher VLDL cholesterol (P = 0.080), a 12% higher ratio of LDL to HDL cholesterol (P = 0.002), 22% higher plasma total triacylglycerol (P = 0.0361), and higher plasma glucose (P = 0.033). Plasma HDL-cholesterol and insulin concentrations and activities of cholesterol ester transfer protein and phospholipid transfer protein did not differ significantly between the diets. CONCLUSIONS: Compared with fat high in oleic acid, MCT fat unfavorably affected lipid profiles in healthy young men by increasing plasma LDL cholesterol and triacylglycerol. No changes in the activities of phospholipid transfer protein and cholesterol ester transfer protein were evident. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15051598/Effects_of_medium_chain_fatty_acids_and_oleic_acid_on_blood_lipids_lipoproteins_glucose_insulin_and_lipid_transfer_protein_activities_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/79.4.564 DB - PRIME DP - Unbound Medicine ER -