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Effect of long-term Se deficiency on the antioxidant capacities of rat vascular tissue.
Biol Trace Elem Res. 2004 Apr; 98(1):73-84.BT

Abstract

Selenium (Se) is an essential micronutrient in human health and Se deficiency has been incriminated in the etiology of cardiovascular diseases. However, the effect of long-term Se deficiency on the antioxidant capacities of vascular tissue has not been elucidated. This study was to determine whether long-term Se deficiency might affect the antioxidant capacity of rat vascular tissue and whether the diet Se might affect the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TR) in rat vascular tissue. Weanling male Wister rats were fed Se-deficient and Se-adequate diets for 12 mo. Se was supplemented in drinking water (1 microg Se/mL) for 1 mo. The arterial walls isolated from various groups were used in the assay. In comparison with the control, Se-deficient rats exhibited significant decreases of GPx activity and total antioxidant capacity in the arterial wall. Similar decreases appeared in the heart, liver, and kidney. The superoxide dismutase activity was also decreased in the Se-deficient rat's arterial wall. Followed by Se supplementation, they were restored to different extents. TR activity was decreased in the heart, liver, and kidney, but increased in the arterial wall. The content of malondialdehyde was increased markedly in Se-deficient rats. In conclusion, a positive correlation exists between dietary Se and antioxidant capacity of rat vascular tissue except TR. It seems that the activities of GPx and TR in the rat arterial wall were mediated in different pathways by the Se status.

Authors+Show Affiliations

Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15051902

Citation

Wu, Qingzhi, and Kaixun Huang. "Effect of Long-term Se Deficiency On the Antioxidant Capacities of Rat Vascular Tissue." Biological Trace Element Research, vol. 98, no. 1, 2004, pp. 73-84.
Wu Q, Huang K. Effect of long-term Se deficiency on the antioxidant capacities of rat vascular tissue. Biol Trace Elem Res. 2004;98(1):73-84.
Wu, Q., & Huang, K. (2004). Effect of long-term Se deficiency on the antioxidant capacities of rat vascular tissue. Biological Trace Element Research, 98(1), 73-84.
Wu Q, Huang K. Effect of Long-term Se Deficiency On the Antioxidant Capacities of Rat Vascular Tissue. Biol Trace Elem Res. 2004;98(1):73-84. PubMed PMID: 15051902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of long-term Se deficiency on the antioxidant capacities of rat vascular tissue. AU - Wu,Qingzhi, AU - Huang,Kaixun, PY - 2003/08/12/received PY - 2003/09/05/accepted PY - 2004/3/31/pubmed PY - 2004/11/9/medline PY - 2004/3/31/entrez SP - 73 EP - 84 JF - Biological trace element research JO - Biol Trace Elem Res VL - 98 IS - 1 N2 - Selenium (Se) is an essential micronutrient in human health and Se deficiency has been incriminated in the etiology of cardiovascular diseases. However, the effect of long-term Se deficiency on the antioxidant capacities of vascular tissue has not been elucidated. This study was to determine whether long-term Se deficiency might affect the antioxidant capacity of rat vascular tissue and whether the diet Se might affect the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TR) in rat vascular tissue. Weanling male Wister rats were fed Se-deficient and Se-adequate diets for 12 mo. Se was supplemented in drinking water (1 microg Se/mL) for 1 mo. The arterial walls isolated from various groups were used in the assay. In comparison with the control, Se-deficient rats exhibited significant decreases of GPx activity and total antioxidant capacity in the arterial wall. Similar decreases appeared in the heart, liver, and kidney. The superoxide dismutase activity was also decreased in the Se-deficient rat's arterial wall. Followed by Se supplementation, they were restored to different extents. TR activity was decreased in the heart, liver, and kidney, but increased in the arterial wall. The content of malondialdehyde was increased markedly in Se-deficient rats. In conclusion, a positive correlation exists between dietary Se and antioxidant capacity of rat vascular tissue except TR. It seems that the activities of GPx and TR in the rat arterial wall were mediated in different pathways by the Se status. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/15051902/Effect_of_long_term_Se_deficiency_on_the_antioxidant_capacities_of_rat_vascular_tissue_ L2 - https://dx.doi.org/10.1385/BTER:98:1:73 DB - PRIME DP - Unbound Medicine ER -