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[Recent advances in gene change of pancreatic cancer].

Abstract

A large number of data derived from molecular analyses support the hypothesis that human cancer is a genetic disease and a distinct subset of genes have been found to be genetically changed in most tumors. Molecular alterations in pancreatic cancer include: (1) oncogenes such as K-ras, c-myc, c-fos, and c-erbB-2; (2) tumor suppressor genes such as p53, p16, DPC4/SMAD4, and DCC; and (3) growth factors such as EGF, FGF, HGF, PDGF, VEGF, TGF-beta. Genetic alterations of K-ras and p53 are common in human pancreatic cancer, but the occurrence of pancreatic cancer is a multi-step phenomenon in which the accumulation of genetic changes is extremely important.

Authors+Show Affiliations

Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. wangyuyue2002@yahoo.com

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

15052782

Citation

Wang, Yu-yue, and Quan-cai Cui. "[Recent Advances in Gene Change of Pancreatic Cancer]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 1, 2004, pp. 79-82.
Wang YY, Cui QC. [Recent advances in gene change of pancreatic cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(1):79-82.
Wang, Y. Y., & Cui, Q. C. (2004). [Recent advances in gene change of pancreatic cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(1), pp. 79-82.
Wang YY, Cui QC. [Recent Advances in Gene Change of Pancreatic Cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(1):79-82. PubMed PMID: 15052782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Recent advances in gene change of pancreatic cancer]. AU - Wang,Yu-yue, AU - Cui,Quan-cai, PY - 2004/4/1/pubmed PY - 2004/7/23/medline PY - 2004/4/1/entrez SP - 79 EP - 82 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 1 N2 - A large number of data derived from molecular analyses support the hypothesis that human cancer is a genetic disease and a distinct subset of genes have been found to be genetically changed in most tumors. Molecular alterations in pancreatic cancer include: (1) oncogenes such as K-ras, c-myc, c-fos, and c-erbB-2; (2) tumor suppressor genes such as p53, p16, DPC4/SMAD4, and DCC; and (3) growth factors such as EGF, FGF, HGF, PDGF, VEGF, TGF-beta. Genetic alterations of K-ras and p53 are common in human pancreatic cancer, but the occurrence of pancreatic cancer is a multi-step phenomenon in which the accumulation of genetic changes is extremely important. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15052782/[Recent_advances_in_gene_change_of_pancreatic_cancer]_ L2 - http://www.diseaseinfosearch.org/result/5551 DB - PRIME DP - Unbound Medicine ER -