Tags

Type your tag names separated by a space and hit enter

Reduction of soluble adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab.
Arch Immunol Ther Exp (Warsz). 2004 Jan-Feb; 52(1):36-42.AI

Abstract

INTRODUCTION

The purpose of this study was to determine the effect of repeated infusions of infliximab, a chimeric anti-tumor necrosis factor (anti-TNF)-alpha antibody, on the levels of soluble adhesion molecules and vascular endothelial growth factor (VEGF) in patients with active rheumatoid arthritis (RA).

MATERIALS AND METHODS

The treatment design consisted of 9 infusions of infliximab (3 mg/kg) at weeks 0, 2, 6, and every 8 weeks thereafter. All patients had been receiving methotrexate (MTX; 7.5-20 mg/week). Serum levels of soluble intercellular adhesion molecule (sICAM)-1, vascular cell adhesion molecule (sVCAM)-1, E-selectin (sE-selectin), and VEGF were measured by ELISA at weeks 0, 2, 6, 14, and 38 prior to infusion, and at week 62.

RESULTS

A remarkable decrease in serum sICAM-1 (p<0.001), sVCAM-1 (p<0.01), sE-selectin (p<0.01) and VEGF (p<0.001) levels was observed in RA patients after the initial dose of infliximab. The second administration of the drug was followed by an even more significant suppression of serum sICAM-1, sVCAM-1, sE-selectin, and VEGF (p<0.001 in all cases). Further infliximab infusions also significantly reduced serum soluble adhesion molecules and VEGF concentrations, although these were less effective. Infliximab treatment induced a significant decrease in the number of monocytes observed until the end of the study.

CONCLUSIONS

Our study, besides a rapid suppression of disease activity, showed that serum soluble adhesion molecules and VEGF concentrations are down-regulated following anti-TNF-alpha antibody therapy combined with MTX. Repeated doses of infliximab sustained the reductions in the soluble adhesion molecules and VEGF concentrations, although they were less effective than the first and second infusions of infliximab.

Authors+Show Affiliations

Department of Rheumatology and Internal Diseases, Medical University of Białystok, Białystok, Poland. klimp@amb.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15053231

Citation

Klimiuk, Piotr A., et al. "Reduction of Soluble Adhesion Molecules (sICAM-1, sVCAM-1, and sE-selectin) and Vascular Endothelial Growth Factor Levels in Serum of Rheumatoid Arthritis Patients Following Multiple Intravenous Infusions of Infliximab." Archivum Immunologiae Et Therapiae Experimentalis, vol. 52, no. 1, 2004, pp. 36-42.
Klimiuk PA, Sierakowski S, Domysławska I, et al. Reduction of soluble adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab. Arch Immunol Ther Exp (Warsz). 2004;52(1):36-42.
Klimiuk, P. A., Sierakowski, S., Domysławska, I., Fiedorczyk, M., & Chwiećko, J. (2004). Reduction of soluble adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab. Archivum Immunologiae Et Therapiae Experimentalis, 52(1), 36-42.
Klimiuk PA, et al. Reduction of Soluble Adhesion Molecules (sICAM-1, sVCAM-1, and sE-selectin) and Vascular Endothelial Growth Factor Levels in Serum of Rheumatoid Arthritis Patients Following Multiple Intravenous Infusions of Infliximab. Arch Immunol Ther Exp (Warsz). 2004 Jan-Feb;52(1):36-42. PubMed PMID: 15053231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of soluble adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab. AU - Klimiuk,Piotr A, AU - Sierakowski,Stanisław, AU - Domysławska,Izabela, AU - Fiedorczyk,Małgorzata, AU - Chwiećko,Justyna, PY - 2003/04/22/received PY - 2003/08/20/accepted PY - 2004/4/1/pubmed PY - 2004/11/13/medline PY - 2004/4/1/entrez SP - 36 EP - 42 JF - Archivum immunologiae et therapiae experimentalis JO - Arch Immunol Ther Exp (Warsz) VL - 52 IS - 1 N2 - INTRODUCTION: The purpose of this study was to determine the effect of repeated infusions of infliximab, a chimeric anti-tumor necrosis factor (anti-TNF)-alpha antibody, on the levels of soluble adhesion molecules and vascular endothelial growth factor (VEGF) in patients with active rheumatoid arthritis (RA). MATERIALS AND METHODS: The treatment design consisted of 9 infusions of infliximab (3 mg/kg) at weeks 0, 2, 6, and every 8 weeks thereafter. All patients had been receiving methotrexate (MTX; 7.5-20 mg/week). Serum levels of soluble intercellular adhesion molecule (sICAM)-1, vascular cell adhesion molecule (sVCAM)-1, E-selectin (sE-selectin), and VEGF were measured by ELISA at weeks 0, 2, 6, 14, and 38 prior to infusion, and at week 62. RESULTS: A remarkable decrease in serum sICAM-1 (p<0.001), sVCAM-1 (p<0.01), sE-selectin (p<0.01) and VEGF (p<0.001) levels was observed in RA patients after the initial dose of infliximab. The second administration of the drug was followed by an even more significant suppression of serum sICAM-1, sVCAM-1, sE-selectin, and VEGF (p<0.001 in all cases). Further infliximab infusions also significantly reduced serum soluble adhesion molecules and VEGF concentrations, although these were less effective. Infliximab treatment induced a significant decrease in the number of monocytes observed until the end of the study. CONCLUSIONS: Our study, besides a rapid suppression of disease activity, showed that serum soluble adhesion molecules and VEGF concentrations are down-regulated following anti-TNF-alpha antibody therapy combined with MTX. Repeated doses of infliximab sustained the reductions in the soluble adhesion molecules and VEGF concentrations, although they were less effective than the first and second infusions of infliximab. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/15053231/Reduction_of_soluble_adhesion_molecules__sICAM_1_sVCAM_1_and_sE_selectin__and_vascular_endothelial_growth_factor_levels_in_serum_of_rheumatoid_arthritis_patients_following_multiple_intravenous_infusions_of_infliximab_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -