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Timing of fear expression in trace and delay conditioning measured by fear-potentiated startle in rats.
Learn Mem. 2004 Mar-Apr; 11(2):205-12.LM

Abstract

In two experiments, the time course of the expression of fear in trace (hippocampus-dependent) versus delay (hippocampus-independent) conditioning was characterized with a high degree of temporal specificity using fear-potentiated startle. In experiment 1, groups of rats were given delay fear conditioning or trace fear conditioning with a 3- or 12-sec trace interval between conditioned stimulus (CS) offset and unconditioned stimulus (US) onset. During test, the delay group showed fear-potentiated startle in the presence of the CS but not after its offset, whereas the trace groups showed fear-potentiated startle both during the CS and after its offset. Experiment 2 compared the time course of fear expression after trace conditioning with the time course in two delay conditioning groups: one matched to the trace conditioning group with respect to CS duration, and the other with respect to ISI. In all groups, fear was expressed until the scheduled occurrence of the US and returned to baseline rapidly thereafter. Thus, in both trace and delay fear conditioning, ISI is a critical determinant of the time course of fear expression. These results are informative as to the possible role of neural structures, such as the hippocampus, in memory processes related to temporal information.

Links

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Authors+Show Affiliations

Burman MA
University of Minnesota, Minneapolis, Minnesota 55455, USA.
Gewirtz JC
No affiliation info available

MeSH

Acoustic StimulationAnimalsAssociation LearningConditioning, OperantCuesFearHippocampusMaleRatsRats, Sprague-DawleyReflex, StartleTime Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15054136

Citation

Burman, Michael A., and Jonathan C. Gewirtz. "Timing of Fear Expression in Trace and Delay Conditioning Measured By Fear-potentiated Startle in Rats." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 11, no. 2, 2004, pp. 205-12.
Burman MA, Gewirtz JC. Timing of fear expression in trace and delay conditioning measured by fear-potentiated startle in rats. Learn Mem. 2004;11(2):205-12.
Burman, M. A., & Gewirtz, J. C. (2004). Timing of fear expression in trace and delay conditioning measured by fear-potentiated startle in rats. Learning & Memory (Cold Spring Harbor, N.Y.), 11(2), 205-12.
Burman MA, Gewirtz JC. Timing of Fear Expression in Trace and Delay Conditioning Measured By Fear-potentiated Startle in Rats. Learn Mem. 2004 Mar-Apr;11(2):205-12. PubMed PMID: 15054136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Timing of fear expression in trace and delay conditioning measured by fear-potentiated startle in rats. AU - Burman,Michael A, AU - Gewirtz,Jonathan C, PY - 2004/4/1/pubmed PY - 2004/12/16/medline PY - 2004/4/1/entrez SP - 205 EP - 12 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 11 IS - 2 N2 - In two experiments, the time course of the expression of fear in trace (hippocampus-dependent) versus delay (hippocampus-independent) conditioning was characterized with a high degree of temporal specificity using fear-potentiated startle. In experiment 1, groups of rats were given delay fear conditioning or trace fear conditioning with a 3- or 12-sec trace interval between conditioned stimulus (CS) offset and unconditioned stimulus (US) onset. During test, the delay group showed fear-potentiated startle in the presence of the CS but not after its offset, whereas the trace groups showed fear-potentiated startle both during the CS and after its offset. Experiment 2 compared the time course of fear expression after trace conditioning with the time course in two delay conditioning groups: one matched to the trace conditioning group with respect to CS duration, and the other with respect to ISI. In all groups, fear was expressed until the scheduled occurrence of the US and returned to baseline rapidly thereafter. Thus, in both trace and delay fear conditioning, ISI is a critical determinant of the time course of fear expression. These results are informative as to the possible role of neural structures, such as the hippocampus, in memory processes related to temporal information. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/15054136/Timing_of_fear_expression_in_trace_and_delay_conditioning_measured_by_fear_potentiated_startle_in_rats_ DB - PRIME DP - Unbound Medicine ER -