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Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome.
Diabetes Obes Metab. 2004 May; 6(3):208-15.DO

Abstract

BACKGROUND

Mild hypoandrogenism in men, usually defined by low levels of testosterone, is a peculiar feature of abdominal obesity that independently predicts the development of insulin resistance and diabetes mellitus. Little is known about the short- and long-term effects of weight loss on sex steroids in abdominally obese men, however.

OBJECTIVES

We assessed the effect of rapid weight loss and sustained weight maintenance on the plasma concentrations of testosterone and other sex hormones in 58 abdominally obese men (age, 46.3 +/- 7.5 years; body mass index, 36.1 +/- 3.8 kg/m(2); waist girth, 121 +/- 10 cm) with the metabolic syndrome.

RESULTS

The men lost on average 16.3 +/- 4.5 kg during a 9-week very low-calorie diet (VLCD) and maintained 14.3 +/- 9.1 kg weight loss after a 12-month maintenance period (vs. baseline, p < 0.001). Sex hormone-binding globulin (SHBG) increased from 27.6 +/- 11.9 to 48.1 +/- 23.5 nmol/l during the VLCD but decreased to 32.6 +/- 12.9 nmol/l during weight maintenance, which was still higher than at baseline (p < 0.001). Free testosterone (fT) increased from 185 +/- 66 to 208 +/- 70 pmol/l (p = 0.002) during the VLCD and remained high after 1 year of weight maintenance (212 +/- 84 pmol/l, p = 0.002). Total testosterone levels followed a pattern intermediate between fT and SHBG. Plasma estradiol and dehydroepiandrosterone sulphate concentrations changed only transiently or not at all.

CONCLUSIONS

Rapid weight loss with successful weight maintenance in abdominally obese men with the metabolic syndrome brings about a sustained increase in fT levels. The dramatic increase in SHBG attenuated initially during weight maintenance but remained elevated. These findings may be important with regard to prevention of progressive metabolic decompensation and cardiovascular disease associated with obesity and the metabolic syndrome.

Authors+Show Affiliations

Niskanen L
Department of Medicine, Kuopio University Hospital, Kuopio, Finland. leo.niskanen@kuh.fi
Laaksonen DE
No affiliation info available
Punnonen K
No affiliation info available
Mustajoki P
No affiliation info available
Kaukua J
No affiliation info available
Rissanen A
No affiliation info available

MeSH

Adipose TissueBody WeightCholesterol, HDLDehydroepiandrosterone SulfateDiet, ReducingEstradiolHumansInsulinMaleMetabolic SyndromeMiddle AgedObesitySex Hormone-Binding GlobulinTestosteroneTriglyceridesWeight Loss

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15056129

Citation

Niskanen, L, et al. "Changes in Sex Hormone-binding Globulin and Testosterone During Weight Loss and Weight Maintenance in Abdominally Obese Men With the Metabolic Syndrome." Diabetes, Obesity & Metabolism, vol. 6, no. 3, 2004, pp. 208-15.
Niskanen L, Laaksonen DE, Punnonen K, et al. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004;6(3):208-15.
Niskanen, L., Laaksonen, D. E., Punnonen, K., Mustajoki, P., Kaukua, J., & Rissanen, A. (2004). Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes, Obesity & Metabolism, 6(3), 208-15.
Niskanen L, et al. Changes in Sex Hormone-binding Globulin and Testosterone During Weight Loss and Weight Maintenance in Abdominally Obese Men With the Metabolic Syndrome. Diabetes Obes Metab. 2004;6(3):208-15. PubMed PMID: 15056129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. AU - Niskanen,L, AU - Laaksonen,D E, AU - Punnonen,K, AU - Mustajoki,P, AU - Kaukua,J, AU - Rissanen,A, PY - 2004/4/2/pubmed PY - 2004/7/21/medline PY - 2004/4/2/entrez SP - 208 EP - 15 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 6 IS - 3 N2 - BACKGROUND: Mild hypoandrogenism in men, usually defined by low levels of testosterone, is a peculiar feature of abdominal obesity that independently predicts the development of insulin resistance and diabetes mellitus. Little is known about the short- and long-term effects of weight loss on sex steroids in abdominally obese men, however. OBJECTIVES: We assessed the effect of rapid weight loss and sustained weight maintenance on the plasma concentrations of testosterone and other sex hormones in 58 abdominally obese men (age, 46.3 +/- 7.5 years; body mass index, 36.1 +/- 3.8 kg/m(2); waist girth, 121 +/- 10 cm) with the metabolic syndrome. RESULTS: The men lost on average 16.3 +/- 4.5 kg during a 9-week very low-calorie diet (VLCD) and maintained 14.3 +/- 9.1 kg weight loss after a 12-month maintenance period (vs. baseline, p < 0.001). Sex hormone-binding globulin (SHBG) increased from 27.6 +/- 11.9 to 48.1 +/- 23.5 nmol/l during the VLCD but decreased to 32.6 +/- 12.9 nmol/l during weight maintenance, which was still higher than at baseline (p < 0.001). Free testosterone (fT) increased from 185 +/- 66 to 208 +/- 70 pmol/l (p = 0.002) during the VLCD and remained high after 1 year of weight maintenance (212 +/- 84 pmol/l, p = 0.002). Total testosterone levels followed a pattern intermediate between fT and SHBG. Plasma estradiol and dehydroepiandrosterone sulphate concentrations changed only transiently or not at all. CONCLUSIONS: Rapid weight loss with successful weight maintenance in abdominally obese men with the metabolic syndrome brings about a sustained increase in fT levels. The dramatic increase in SHBG attenuated initially during weight maintenance but remained elevated. These findings may be important with regard to prevention of progressive metabolic decompensation and cardiovascular disease associated with obesity and the metabolic syndrome. SN - 1462-8902 UR - https://www.unboundmedicine.com/medline/citation/15056129/Changes_in_sex_hormone_binding_globulin_and_testosterone_during_weight_loss_and_weight_maintenance_in_abdominally_obese_men_with_the_metabolic_syndrome_ DB - PRIME DP - Unbound Medicine ER -