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ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae.
Nucleic Acids Res. 2004; 32(6):1993-9.NA

Abstract

We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core component of the SSU processome. These data indicate that Esf1p plays a direct role in early pre-rRNA processing.

Authors+Show Affiliations

Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15056729

Citation

Peng, Wen-Tao, et al. "ESF1 Is Required for 18S rRNA Synthesis in Saccharomyces Cerevisiae." Nucleic Acids Research, vol. 32, no. 6, 2004, pp. 1993-9.
Peng WT, Krogan NJ, Richards DP, et al. ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res. 2004;32(6):1993-9.
Peng, W. T., Krogan, N. J., Richards, D. P., Greenblatt, J. F., & Hughes, T. R. (2004). ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Research, 32(6), 1993-9.
Peng WT, et al. ESF1 Is Required for 18S rRNA Synthesis in Saccharomyces Cerevisiae. Nucleic Acids Res. 2004;32(6):1993-9. PubMed PMID: 15056729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. AU - Peng,Wen-Tao, AU - Krogan,Nevan J, AU - Richards,Dawn P, AU - Greenblatt,Jack F, AU - Hughes,Timothy R, Y1 - 2004/03/31/ PY - 2004/4/2/pubmed PY - 2004/7/23/medline PY - 2004/4/2/entrez SP - 1993 EP - 9 JF - Nucleic acids research JO - Nucleic Acids Res VL - 32 IS - 6 N2 - We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core component of the SSU processome. These data indicate that Esf1p plays a direct role in early pre-rRNA processing. SN - 1362-4962 UR - https://www.unboundmedicine.com/medline/citation/15056729/ESF1_is_required_for_18S_rRNA_synthesis_in_Saccharomyces_cerevisiae_ L2 - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkh518 DB - PRIME DP - Unbound Medicine ER -