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Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin.
Chem Pharm Bull (Tokyo). 2004 Apr; 52(4):494-7.CP

Abstract

New dolabellane-type diterpene alkaloids, nigellamines A(3), A(4), A(5), and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A(5) was equivalent to that of the hypolipidemic agent, clofibrate.

Authors+Show Affiliations

Kyoto Pharmaceutical University, Misasagi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15056976

Citation

Morikawa, Toshio, et al. "Nigellamines A3, A4, A5, and C, New Dolabellane-type Diterpene Alkaloids, With Lipid Metabolism-promoting Activities From the Egyptian Medicinal Food Black Cumin." Chemical & Pharmaceutical Bulletin, vol. 52, no. 4, 2004, pp. 494-7.
Morikawa T, Xu F, Ninomiya K, et al. Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Chem Pharm Bull (Tokyo). 2004;52(4):494-7.
Morikawa, T., Xu, F., Ninomiya, K., Matsuda, H., & Yoshikawa, M. (2004). Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Chemical & Pharmaceutical Bulletin, 52(4), 494-7.
Morikawa T, et al. Nigellamines A3, A4, A5, and C, New Dolabellane-type Diterpene Alkaloids, With Lipid Metabolism-promoting Activities From the Egyptian Medicinal Food Black Cumin. Chem Pharm Bull (Tokyo). 2004;52(4):494-7. PubMed PMID: 15056976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. AU - Morikawa,Toshio, AU - Xu,Fengming, AU - Ninomiya,Kiyofumi, AU - Matsuda,Hisashi, AU - Yoshikawa,Masayuki, PY - 2004/4/2/pubmed PY - 2004/11/13/medline PY - 2004/4/2/entrez SP - 494 EP - 7 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 52 IS - 4 N2 - New dolabellane-type diterpene alkaloids, nigellamines A(3), A(4), A(5), and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A(5) was equivalent to that of the hypolipidemic agent, clofibrate. SN - 0009-2363 UR - https://www.unboundmedicine.com/medline/citation/15056976/Nigellamines_A3_A4_A5_and_C_new_dolabellane_type_diterpene_alkaloids_with_lipid_metabolism_promoting_activities_from_the_Egyptian_medicinal_food_black_cumin_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/52.494?from=PubMed DB - PRIME DP - Unbound Medicine ER -