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Constitutional and environmental risk factors for cutaneous melanoma in an Italian population. A case-control study.

Abstract

The aim of this study was to determine the relative risk for cutaneous melanoma associated with phenotypic and environmental variables in a population in central Italy and to assess how the combination of the different risk factors contributes to the overall risk for melanoma. We performed a case-control study of 100 patients with sporadic cutaneous melanoma and 200 controls matched for sex, age, ethnicity and residential area. Individuals were interviewed concerning pigmentary traits and sun exposure, and underwent a total body skin examination. Logistic regression models were used to evaluate the association between cutaneous melanoma and constitutional and environmental variables. The strongest risk factors were prolonged recreational sun exposure (odds ratio [OR] 5.010, 95% confidence interval [CI] 2.110-11.891), the presence of clinically atypical naevi (OR 4.916, 95% CI 2.496-9.995) and the presence of >50 common melanocytic naevi (OR 4.684, 95% CI 2.442-9.231). In addition, occupational sun exposure (OR 2.573, 95% CI 1.399-4.732), light brown hair (OR 2.336, 95% CI 1.328-4.138), high density of solar lentigos and/or actinic keratoses (OR 1.824, 95% CI 1.0-3.510) and type II, fair skin (OR 1.815, 95% CI 1.031-3.193) and blue eyes (OR 1.757, 95% CI 1.0-3.477) were each significantly associated with cutaneous melanoma risk. The combination of individual strong risk factors was associated with up to a 46-fold increase in the risk for cutaneous melanoma. Selected pigmentary traits, sun exposure and melanocytic naevi, individually and in combination, are important risk factors for cutaneous melanoma in an Italian population.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, University of L'Aquila, Via Vetoio-Coppito 2, 67100 L'Aquila, Italy.

    , , , ,

    Source

    Melanoma research 14:2 2004 Apr pg 151-7

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Environmental Exposure
    Female
    Hair Color
    Humans
    Italy
    Male
    Melanoma
    Middle Aged
    Odds Ratio
    Risk Factors
    Skin Neoplasms
    Sunlight

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15057047

    Citation

    Fargnoli, Maria Concetta, et al. "Constitutional and Environmental Risk Factors for Cutaneous Melanoma in an Italian Population. a Case-control Study." Melanoma Research, vol. 14, no. 2, 2004, pp. 151-7.
    Fargnoli MC, Piccolo D, Altobelli E, et al. Constitutional and environmental risk factors for cutaneous melanoma in an Italian population. A case-control study. Melanoma Res. 2004;14(2):151-7.
    Fargnoli, M. C., Piccolo, D., Altobelli, E., Formicone, F., Chimenti, S., & Peris, K. (2004). Constitutional and environmental risk factors for cutaneous melanoma in an Italian population. A case-control study. Melanoma Research, 14(2), pp. 151-7.
    Fargnoli MC, et al. Constitutional and Environmental Risk Factors for Cutaneous Melanoma in an Italian Population. a Case-control Study. Melanoma Res. 2004;14(2):151-7. PubMed PMID: 15057047.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Constitutional and environmental risk factors for cutaneous melanoma in an Italian population. A case-control study. AU - Fargnoli,Maria Concetta, AU - Piccolo,Domenico, AU - Altobelli,Emma, AU - Formicone,Federica, AU - Chimenti,Sergio, AU - Peris,Ketty, PY - 2004/4/2/pubmed PY - 2005/1/12/medline PY - 2004/4/2/entrez SP - 151 EP - 7 JF - Melanoma research JO - Melanoma Res. VL - 14 IS - 2 N2 - The aim of this study was to determine the relative risk for cutaneous melanoma associated with phenotypic and environmental variables in a population in central Italy and to assess how the combination of the different risk factors contributes to the overall risk for melanoma. We performed a case-control study of 100 patients with sporadic cutaneous melanoma and 200 controls matched for sex, age, ethnicity and residential area. Individuals were interviewed concerning pigmentary traits and sun exposure, and underwent a total body skin examination. Logistic regression models were used to evaluate the association between cutaneous melanoma and constitutional and environmental variables. The strongest risk factors were prolonged recreational sun exposure (odds ratio [OR] 5.010, 95% confidence interval [CI] 2.110-11.891), the presence of clinically atypical naevi (OR 4.916, 95% CI 2.496-9.995) and the presence of >50 common melanocytic naevi (OR 4.684, 95% CI 2.442-9.231). In addition, occupational sun exposure (OR 2.573, 95% CI 1.399-4.732), light brown hair (OR 2.336, 95% CI 1.328-4.138), high density of solar lentigos and/or actinic keratoses (OR 1.824, 95% CI 1.0-3.510) and type II, fair skin (OR 1.815, 95% CI 1.031-3.193) and blue eyes (OR 1.757, 95% CI 1.0-3.477) were each significantly associated with cutaneous melanoma risk. The combination of individual strong risk factors was associated with up to a 46-fold increase in the risk for cutaneous melanoma. Selected pigmentary traits, sun exposure and melanocytic naevi, individually and in combination, are important risk factors for cutaneous melanoma in an Italian population. SN - 0960-8931 UR - https://www.unboundmedicine.com/medline/citation/15057047/Constitutional_and_environmental_risk_factors_for_cutaneous_melanoma_in_an_Italian_population__A_case_control_study_ L2 - http://Insights.ovid.com/pubmed?pmid=15057047 DB - PRIME DP - Unbound Medicine ER -