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[Mucositis--a major non-hematologic complication of high-dose chemotherapy and radiotherapy--pathogenesis, prevention and treatment].
Przegl Lek 2003; 60(12):815-20PL

Abstract

High-dose chemotherapy and radiotherapy--induced oral mucositis (OM) represents a major non-hematologic complication of stem cell transplantation in cancer patients. This side effect causes significant treatment-related morbidity and is an important clinical problem because of the pain, odynodysphagia, the requirement for parenteral nutrition, narcotics and the risk of local infections which are exacerbated by the severe neutropenia and can become systemic. The pathogenesis of OM can be attributed to the direct mucosal toxicity of high-dose chemotherapy and ionizing radiation and to indirect mucosal damage caused by a concomitant local bacterial, viral and mycotic infections. This review describes pathophysiology as well as prophylactic and therapeutic armamentarium for the treatment of oral mucositis in patients receiving high dose chemotherapy and/or radiotherapy.

Authors+Show Affiliations

Katedra i Klinika Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie. bjakubas@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

15058023

Citation

Piatkowska-Jakubas, Beata, et al. "[Mucositis--a Major Non-hematologic Complication of High-dose Chemotherapy and Radiotherapy--pathogenesis, Prevention and Treatment]." Przeglad Lekarski, vol. 60, no. 12, 2003, pp. 815-20.
Piatkowska-Jakubas B, Darczuk D, Chomyszyn-Gajewska M, et al. [Mucositis--a major non-hematologic complication of high-dose chemotherapy and radiotherapy--pathogenesis, prevention and treatment]. Prz Lek. 2003;60(12):815-20.
Piatkowska-Jakubas, B., Darczuk, D., Chomyszyn-Gajewska, M., & Skotnicki, A. B. (2003). [Mucositis--a major non-hematologic complication of high-dose chemotherapy and radiotherapy--pathogenesis, prevention and treatment]. Przeglad Lekarski, 60(12), pp. 815-20.
Piatkowska-Jakubas B, et al. [Mucositis--a Major Non-hematologic Complication of High-dose Chemotherapy and Radiotherapy--pathogenesis, Prevention and Treatment]. Prz Lek. 2003;60(12):815-20. PubMed PMID: 15058023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mucositis--a major non-hematologic complication of high-dose chemotherapy and radiotherapy--pathogenesis, prevention and treatment]. AU - Piatkowska-Jakubas,Beata, AU - Darczuk,Dagmara, AU - Chomyszyn-Gajewska,Maria, AU - Skotnicki,Aleksander B, PY - 2004/4/3/pubmed PY - 2004/6/2/medline PY - 2004/4/3/entrez SP - 815 EP - 20 JF - Przeglad lekarski JO - Prz. Lek. VL - 60 IS - 12 N2 - High-dose chemotherapy and radiotherapy--induced oral mucositis (OM) represents a major non-hematologic complication of stem cell transplantation in cancer patients. This side effect causes significant treatment-related morbidity and is an important clinical problem because of the pain, odynodysphagia, the requirement for parenteral nutrition, narcotics and the risk of local infections which are exacerbated by the severe neutropenia and can become systemic. The pathogenesis of OM can be attributed to the direct mucosal toxicity of high-dose chemotherapy and ionizing radiation and to indirect mucosal damage caused by a concomitant local bacterial, viral and mycotic infections. This review describes pathophysiology as well as prophylactic and therapeutic armamentarium for the treatment of oral mucositis in patients receiving high dose chemotherapy and/or radiotherapy. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/15058023/[Mucositis__a_major_non_hematologic_complication_of_high_dose_chemotherapy_and_radiotherapy__pathogenesis_prevention_and_treatment]_ L2 - https://medlineplus.gov/radiationtherapy.html DB - PRIME DP - Unbound Medicine ER -