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A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care.
J Clin Periodontol 2004; 31(1):45-51JC

Abstract

OBJECTIVE

To evaluate the clinical and microbiological activity of a new mouth rinse formulation, used as an adjunct to oral hygiene, for patients in supportive periodontal care.

PATIENTS AND METHODS

This was a randomized, placebo-controlled clinical trial with two groups: test group, rinsing twice per day with the test product (with 0.05% chlorhexidine and 0.05% cetylpyridinium chloride); and control group, rinsing with a placebo. Treated chronic periodontitis patients were included, and two visits were rendered, baseline, and after 15 days. Clinical outcome variables included plaque and gingival indices, and probing pocket depth. Subgingival samples were processed by culturing. Patient-based variables and adverse effects were also assessed. Outcome variables were compared by t-test, chi2, and Mann-Whitney test.

RESULTS

The results belonged to 33 patients. Plaque and gingival indices, and the log of bacterial total counts were reduced in the test group (p < or = 0.01), but differences between groups were only statistically significant (p < 0.05) for plaque and bacterial counts. A significant reduction in the proportions of flora (p < 0.05) and frequency of detection (p = 0.01) of Porphyromonas gingivalis was observed in the test group.

CONCLUSIONS

The newly formulated mouth rinse demonstrated short-term plaque-inhibitory activity. This was associated with a reduction in the total load of anaerobic subgingival microflora.

Authors+Show Affiliations

Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15058374

Citation

Santos, Sagrario, et al. "A Randomized Clinical Trial On the Short-term Clinical and Microbiological Effects of the Adjunctive Use of a 0.05% Chlorhexidine Mouth Rinse for Patients in Supportive Periodontal Care." Journal of Clinical Periodontology, vol. 31, no. 1, 2004, pp. 45-51.
Santos S, Herrera D, López E, et al. A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care. J Clin Periodontol. 2004;31(1):45-51.
Santos, S., Herrera, D., López, E., O'Connor, A., González, I., & Sanz, M. (2004). A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care. Journal of Clinical Periodontology, 31(1), pp. 45-51.
Santos S, et al. A Randomized Clinical Trial On the Short-term Clinical and Microbiological Effects of the Adjunctive Use of a 0.05% Chlorhexidine Mouth Rinse for Patients in Supportive Periodontal Care. J Clin Periodontol. 2004;31(1):45-51. PubMed PMID: 15058374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care. AU - Santos,Sagrario, AU - Herrera,David, AU - López,Elsa, AU - O'Connor,Ana, AU - González,Itziar, AU - Sanz,Mariano, PY - 2004/4/3/pubmed PY - 2004/4/23/medline PY - 2004/4/3/entrez SP - 45 EP - 51 JF - Journal of clinical periodontology JO - J. Clin. Periodontol. VL - 31 IS - 1 N2 - OBJECTIVE: To evaluate the clinical and microbiological activity of a new mouth rinse formulation, used as an adjunct to oral hygiene, for patients in supportive periodontal care. PATIENTS AND METHODS: This was a randomized, placebo-controlled clinical trial with two groups: test group, rinsing twice per day with the test product (with 0.05% chlorhexidine and 0.05% cetylpyridinium chloride); and control group, rinsing with a placebo. Treated chronic periodontitis patients were included, and two visits were rendered, baseline, and after 15 days. Clinical outcome variables included plaque and gingival indices, and probing pocket depth. Subgingival samples were processed by culturing. Patient-based variables and adverse effects were also assessed. Outcome variables were compared by t-test, chi2, and Mann-Whitney test. RESULTS: The results belonged to 33 patients. Plaque and gingival indices, and the log of bacterial total counts were reduced in the test group (p < or = 0.01), but differences between groups were only statistically significant (p < 0.05) for plaque and bacterial counts. A significant reduction in the proportions of flora (p < 0.05) and frequency of detection (p = 0.01) of Porphyromonas gingivalis was observed in the test group. CONCLUSIONS: The newly formulated mouth rinse demonstrated short-term plaque-inhibitory activity. This was associated with a reduction in the total load of anaerobic subgingival microflora. SN - 0303-6979 UR - https://www.unboundmedicine.com/medline/citation/15058374/A_randomized_clinical_trial_on_the_short_term_clinical_and_microbiological_effects_of_the_adjunctive_use_of_a_0_05_chlorhexidine_mouth_rinse_for_patients_in_supportive_periodontal_care_ L2 - https://doi.org/10.1111/j.0303-6979.2004.00438.x DB - PRIME DP - Unbound Medicine ER -