Tags

Type your tag names separated by a space and hit enter

[The contrast study of Pre-S1 protein, HBV-DNA and HBeAg in diagnosing viral replication in patients with chronic hepatitis B].
Zhonghua Gan Zang Bing Za Zhi. 2004 Mar; 12(3):134-6.ZG

Abstract

OBJECTIVE

To determine the role of Pre-S1 protein in diagnosing viral replication in patients with chronic hepatitis B.

METHODS

104 consecutive patients with chronic hepatitis B were included in the study, liver biopsy were performed in all patients. Serial serum samples were studied with the quantitative determination of HBV-DNA by a quantitative PCR assay, determination of Pre-S1 protein by ELISA.

RESULTS

The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg HBeAg anti-HBc (+) both were 96.5%. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBe anti-HBc (+) were 81.5%, 72.3%, respectively. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBc (+) were 87.5%, 75.0%, respectively. It represented some patients with HBeAg (-) anti-HBe (+/-) still had viral replication. HBV-DNA>10(3) copy/ml as positive criteria for diagnosing viral replication, the positive rate of HBeAg, Pre-S1 were 31.5% (28/89), 80.9% (72/89) in patients with HBV-DNA>10(3) copy/ml, respectively. The concordance rates of HBeAg, Pre-S1 with HBV-DNA were 40.0% (42/104), 82.0% (85/104), respectively.

CONCLUSION

It showed that Pre-S1 was more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.

Authors+Show Affiliations

Liver Research Center, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15059293

Citation

Li, Qin, et al. "[The Contrast Study of Pre-S1 Protein, HBV-DNA and HBeAg in Diagnosing Viral Replication in Patients With Chronic Hepatitis B]." Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, vol. 12, no. 3, 2004, pp. 134-6.
Li Q, Sun GZ, Wei YX, et al. [The contrast study of Pre-S1 protein, HBV-DNA and HBeAg in diagnosing viral replication in patients with chronic hepatitis B]. Zhonghua Gan Zang Bing Za Zhi. 2004;12(3):134-6.
Li, Q., Sun, G. Z., Wei, Y. X., Min, Y. Y., Cong, Y. L., Ou, X. J., & Wang, B. E. (2004). [The contrast study of Pre-S1 protein, HBV-DNA and HBeAg in diagnosing viral replication in patients with chronic hepatitis B]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, 12(3), 134-6.
Li Q, et al. [The Contrast Study of Pre-S1 Protein, HBV-DNA and HBeAg in Diagnosing Viral Replication in Patients With Chronic Hepatitis B]. Zhonghua Gan Zang Bing Za Zhi. 2004;12(3):134-6. PubMed PMID: 15059293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The contrast study of Pre-S1 protein, HBV-DNA and HBeAg in diagnosing viral replication in patients with chronic hepatitis B]. AU - Li,Qin, AU - Sun,Gui-zhen, AU - Wei,Yu-xiang, AU - Min,Yu-yuan, AU - Cong,Yu-long, AU - Ou,Xiao-juan, AU - Wang,Bao-en, PY - 2004/4/3/pubmed PY - 2004/6/16/medline PY - 2004/4/3/entrez SP - 134 EP - 6 JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology JO - Zhonghua Gan Zang Bing Za Zhi VL - 12 IS - 3 N2 - OBJECTIVE: To determine the role of Pre-S1 protein in diagnosing viral replication in patients with chronic hepatitis B. METHODS: 104 consecutive patients with chronic hepatitis B were included in the study, liver biopsy were performed in all patients. Serial serum samples were studied with the quantitative determination of HBV-DNA by a quantitative PCR assay, determination of Pre-S1 protein by ELISA. RESULTS: The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg HBeAg anti-HBc (+) both were 96.5%. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBe anti-HBc (+) were 81.5%, 72.3%, respectively. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBc (+) were 87.5%, 75.0%, respectively. It represented some patients with HBeAg (-) anti-HBe (+/-) still had viral replication. HBV-DNA>10(3) copy/ml as positive criteria for diagnosing viral replication, the positive rate of HBeAg, Pre-S1 were 31.5% (28/89), 80.9% (72/89) in patients with HBV-DNA>10(3) copy/ml, respectively. The concordance rates of HBeAg, Pre-S1 with HBV-DNA were 40.0% (42/104), 82.0% (85/104), respectively. CONCLUSION: It showed that Pre-S1 was more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B. SN - 1007-3418 UR - https://www.unboundmedicine.com/medline/citation/15059293/[The_contrast_study_of_Pre_S1_protein_HBV_DNA_and_HBeAg_in_diagnosing_viral_replication_in_patients_with_chronic_hepatitis_B]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1007-3418&year=2004&vol=12&issue=3&fpage=134 DB - PRIME DP - Unbound Medicine ER -