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[Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis].
Zhonghua Yi Xue Za Zhi. 2004 Feb 17; 84(4):269-73.ZY

Abstract

OBJECTIVE

To determine the effect of raloxifene hydrochloride (RLX) on the lumbar spine and total hip bone mineral density (BMD), bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis.

METHODS

204 Chinese postmenopausal women with osteoporosis from 3 hospitals in Beijing and Shanghai were randomly divided into 2 groups of 102 women: RLX group (RLX of the dosage of 60 mg/day was given for 12 months) and placebo group. In addition, 500 mg of elemental calcium and 200 units of vitamin D were given daily to all women. BMD, serum bone markers and lipids were measured before and after drug administration. The BMD of lumber spine and hip was measured by dual-energy X-ray absorptiometry (DEXA). Serum bone gamma-carboxyglutamic acid-containing protein (BGP) and C-teloppeptide were analyzed by one-step ELISA. Serum lipids were measured by enzymatic method.

RESULTS

By the end of the 12-month study period, the lumbar spine BMD was increased by 3.3% +/- 4.8% in the RLX group and 1.0% +/- 4.9% in the placebo group (P < 0.001); the hip BMD was increased by 1.4% +/- 4.8%in the RLX group and decreased by 0.9% +/- 5.0% in the placebo group (P < 0.01). New vertebral fracture occurred in none of the subjects in the RLX group and in 5 subjects of the placebo group (P = 0.059). The serum BGP and CTX decreased by 41.7% and 61.5% respectively in the RLX group, both significantly more than those in the placebo group (10.6% and 35.6% respectively, both P < 0.001). Both the total cholesterol and low-density lipoprotein cholesterol were significantly lower in the RLX group than in the placebo group (both P < 0.001), however, there were no significant differences in high-density lipoprotein cholesterol and triglycerides between these two groups. One subject in the RLX group and 5 subjects in the placebo group discontinued the study due to adverse events. There were no differences in the number of subjects with hot flushes (3 in the RLX group and 1 in the placebo group) and the number of subjects with leg cramps (9 in the RLX group and 4 in the placebo group). No venous thromboembolic event was reported.

CONCLUSION

RLX of the dosage of 60 mg/day for 12 months significantly increases the lumbar spine and total hip bone BMD, significantly decreases bone turnover and has favorable effects on serum lipids in Chinese postmenopausal women with osteoporosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, General Hospital of the People's Liberation Army, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

chi

PubMed ID

15059505

Citation

Liu, Jian-li, et al. "[Effect of Raloxifene Hydrochloride On Bone Mineral Density, Bone Metabolism and Serum Lipids in Chinese Postmenopausal Women With Osteoporosis]." Zhonghua Yi Xue Za Zhi, vol. 84, no. 4, 2004, pp. 269-73.
Liu JL, Zhu HM, Huang QR, et al. [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis]. Zhonghua Yi Xue Za Zhi. 2004;84(4):269-73.
Liu, J. L., Zhu, H. M., Huang, Q. R., Zhang, Z. L., Li, H. L., Qin, Y. J., Zhang, Y., Wei, D. L., Lu, J. H., Liu, H., Chen, X. P., Liu, Y. J., Ekangaki, A., Zheng, Y. M., Diez-Perez, A., & Harpe, K. (2004). [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis]. Zhonghua Yi Xue Za Zhi, 84(4), 269-73.
Liu JL, et al. [Effect of Raloxifene Hydrochloride On Bone Mineral Density, Bone Metabolism and Serum Lipids in Chinese Postmenopausal Women With Osteoporosis]. Zhonghua Yi Xue Za Zhi. 2004 Feb 17;84(4):269-73. PubMed PMID: 15059505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis]. AU - Liu,Jian-li, AU - Zhu,Han-min, AU - Huang,Qi-ren, AU - Zhang,Zhong-lan, AU - Li,Hui-lin, AU - Qin,Yue-juan, AU - Zhang,Ying, AU - Wei,Dao-lin, AU - Lu,Jing-hui, AU - Liu,Hui, AU - Chen,Xiao-ping, AU - Liu,Yu-juan, AU - Ekangaki,Abie, AU - Zheng,Yi-man, AU - Diez-Perez,Adolfo, AU - Harpe,Kristine, PY - 2004/4/3/pubmed PY - 2004/8/13/medline PY - 2004/4/3/entrez SP - 269 EP - 73 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 84 IS - 4 N2 - OBJECTIVE: To determine the effect of raloxifene hydrochloride (RLX) on the lumbar spine and total hip bone mineral density (BMD), bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis. METHODS: 204 Chinese postmenopausal women with osteoporosis from 3 hospitals in Beijing and Shanghai were randomly divided into 2 groups of 102 women: RLX group (RLX of the dosage of 60 mg/day was given for 12 months) and placebo group. In addition, 500 mg of elemental calcium and 200 units of vitamin D were given daily to all women. BMD, serum bone markers and lipids were measured before and after drug administration. The BMD of lumber spine and hip was measured by dual-energy X-ray absorptiometry (DEXA). Serum bone gamma-carboxyglutamic acid-containing protein (BGP) and C-teloppeptide were analyzed by one-step ELISA. Serum lipids were measured by enzymatic method. RESULTS: By the end of the 12-month study period, the lumbar spine BMD was increased by 3.3% +/- 4.8% in the RLX group and 1.0% +/- 4.9% in the placebo group (P < 0.001); the hip BMD was increased by 1.4% +/- 4.8%in the RLX group and decreased by 0.9% +/- 5.0% in the placebo group (P < 0.01). New vertebral fracture occurred in none of the subjects in the RLX group and in 5 subjects of the placebo group (P = 0.059). The serum BGP and CTX decreased by 41.7% and 61.5% respectively in the RLX group, both significantly more than those in the placebo group (10.6% and 35.6% respectively, both P < 0.001). Both the total cholesterol and low-density lipoprotein cholesterol were significantly lower in the RLX group than in the placebo group (both P < 0.001), however, there were no significant differences in high-density lipoprotein cholesterol and triglycerides between these two groups. One subject in the RLX group and 5 subjects in the placebo group discontinued the study due to adverse events. There were no differences in the number of subjects with hot flushes (3 in the RLX group and 1 in the placebo group) and the number of subjects with leg cramps (9 in the RLX group and 4 in the placebo group). No venous thromboembolic event was reported. CONCLUSION: RLX of the dosage of 60 mg/day for 12 months significantly increases the lumbar spine and total hip bone BMD, significantly decreases bone turnover and has favorable effects on serum lipids in Chinese postmenopausal women with osteoporosis. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/15059505/[Effect_of_raloxifene_hydrochloride_on_bone_mineral_density_bone_metabolism_and_serum_lipids_in_Chinese_postmenopausal_women_with_osteoporosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2004&amp;vol=84&amp;issue=4&amp;fpage=269 DB - PRIME DP - Unbound Medicine ER -