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Enlargement of parapapillary atrophy in follow-up of chronic open-angle glaucoma.
Am J Ophthalmol. 2004 Apr; 137(4):646-54.AJ

Abstract

PURPOSE

To assess the frequency of an enlargement of parapapillary atrophy in follow-up of eyes with open-angle glaucoma.

METHODS

Prospective observational longitudinal study.

SETTING

Institutional.

PATIENTS

The study included 978 eyes (511 Caucasian subjects) with open-angle glaucoma (n = 548; including 194 eyes with normal-pressure glaucoma), ocular hypertension (n = 289), or without optic nerve disease (n = 141). Highly myopic eyes with a myopic refractive error exceeding -8 diopters were excluded. Mean follow-up was 4.5 +/- 2.4 years (median, 3.8 years; range: 1.5 to 9.8 years).

OBSERVATION PROCEDURES

Optic disk photographs taken annually.

MAIN OUTCOME MEASURES

Two examiners compared optic disk slides for enlargement of parapapillary atrophy (zone beta) and for signs of progressive disk damage.

RESULTS

An enlargement of parapapillary beta zone was detected in 16 eyes (1.6%) after 3.9 +/- 2.6 (0.6 to 9.1) years of follow-up. It was observed in 15 eyes (2.7%) with open-angle glaucoma, 1 eye (0.3%) with ocular hypertension, and in none of the normal eyes. After excluding eyes with a myopic refractive error exceeding -3 diopters, enlargement of beta zone was significantly more common in eyes with progressive glaucoma (5/81 or 6.2%) than in eyes with nonprogressive glaucoma (3/354 or 0.8%; P <.001).

CONCLUSIONS

Parapapillary atrophy (zone beta) enlarges during follow-up of relatively few eyes with chronic open-angle glaucoma. In the refractive range above -3 diopters, enlargement of beta zone occurs significantly more frequently (P <.001) in progressive glaucoma than in nonprogressive glaucoma. In view of its low frequency, enlargement of beta zone may not be a very useful marker for glaucoma progression.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany. wido.budde@augen.ma.uni-heidelberg.deNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15059703

Citation

Budde, Wido M., and Jost B. Jonas. "Enlargement of Parapapillary Atrophy in Follow-up of Chronic Open-angle Glaucoma." American Journal of Ophthalmology, vol. 137, no. 4, 2004, pp. 646-54.
Budde WM, Jonas JB. Enlargement of parapapillary atrophy in follow-up of chronic open-angle glaucoma. Am J Ophthalmol. 2004;137(4):646-54.
Budde, W. M., & Jonas, J. B. (2004). Enlargement of parapapillary atrophy in follow-up of chronic open-angle glaucoma. American Journal of Ophthalmology, 137(4), 646-54.
Budde WM, Jonas JB. Enlargement of Parapapillary Atrophy in Follow-up of Chronic Open-angle Glaucoma. Am J Ophthalmol. 2004;137(4):646-54. PubMed PMID: 15059703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enlargement of parapapillary atrophy in follow-up of chronic open-angle glaucoma. AU - Budde,Wido M, AU - Jonas,Jost B, PY - 2003/11/03/accepted PY - 2004/4/3/pubmed PY - 2004/4/28/medline PY - 2004/4/3/entrez SP - 646 EP - 54 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 137 IS - 4 N2 - PURPOSE: To assess the frequency of an enlargement of parapapillary atrophy in follow-up of eyes with open-angle glaucoma. METHODS: Prospective observational longitudinal study. SETTING: Institutional. PATIENTS: The study included 978 eyes (511 Caucasian subjects) with open-angle glaucoma (n = 548; including 194 eyes with normal-pressure glaucoma), ocular hypertension (n = 289), or without optic nerve disease (n = 141). Highly myopic eyes with a myopic refractive error exceeding -8 diopters were excluded. Mean follow-up was 4.5 +/- 2.4 years (median, 3.8 years; range: 1.5 to 9.8 years). OBSERVATION PROCEDURES: Optic disk photographs taken annually. MAIN OUTCOME MEASURES: Two examiners compared optic disk slides for enlargement of parapapillary atrophy (zone beta) and for signs of progressive disk damage. RESULTS: An enlargement of parapapillary beta zone was detected in 16 eyes (1.6%) after 3.9 +/- 2.6 (0.6 to 9.1) years of follow-up. It was observed in 15 eyes (2.7%) with open-angle glaucoma, 1 eye (0.3%) with ocular hypertension, and in none of the normal eyes. After excluding eyes with a myopic refractive error exceeding -3 diopters, enlargement of beta zone was significantly more common in eyes with progressive glaucoma (5/81 or 6.2%) than in eyes with nonprogressive glaucoma (3/354 or 0.8%; P <.001). CONCLUSIONS: Parapapillary atrophy (zone beta) enlarges during follow-up of relatively few eyes with chronic open-angle glaucoma. In the refractive range above -3 diopters, enlargement of beta zone occurs significantly more frequently (P <.001) in progressive glaucoma than in nonprogressive glaucoma. In view of its low frequency, enlargement of beta zone may not be a very useful marker for glaucoma progression. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15059703/Enlargement_of_parapapillary_atrophy_in_follow_up_of_chronic_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939403014284 DB - PRIME DP - Unbound Medicine ER -