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Multidrug resistant typhoid fever: therapeutic considerations.
Indian Pediatr. 1992 Apr; 29(4):443-8.IP

Abstract

Forty six blood culture positive cases were studied during the current outbreak of multidrug resistant typhoid fever (MRTF). The present outbreak was caused by E1 phage type and organisms were resistant to all commonly used drugs for the treatment of typhoid fever, viz., chloramphenicol (78%), co-trimoxazole (76%) and ampicillin (68%). Treatment failures with chloramphenicol (45.5%) corroborated well with in vitro resistance. No treatment failure was seen with chloramphenicol and ceftriaxone, when these drugs were used in cases infected with sensitive strains. Among the alternative drugs used in cases with in vitro sensitivity, successful clinical response was seen with ceftriaxone (4/4) and cefotaxime (8/9) as compared to cephalexin (3/5) or a combination of cephalexin and furazolidone (9/12).

Authors+Show Affiliations

Department of Pediatrics, Lady Hardinge Medical College, New Delhi.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1506095

Citation

Mishra, S, et al. "Multidrug Resistant Typhoid Fever: Therapeutic Considerations." Indian Pediatrics, vol. 29, no. 4, 1992, pp. 443-8.
Mishra S, Patwari AK, Anand VK, et al. Multidrug resistant typhoid fever: therapeutic considerations. Indian Pediatr. 1992;29(4):443-8.
Mishra, S., Patwari, A. K., Anand, V. K., Pillai, P. K., Aneja, S., Chandra, J., & Sharma, D. (1992). Multidrug resistant typhoid fever: therapeutic considerations. Indian Pediatrics, 29(4), 443-8.
Mishra S, et al. Multidrug Resistant Typhoid Fever: Therapeutic Considerations. Indian Pediatr. 1992;29(4):443-8. PubMed PMID: 1506095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multidrug resistant typhoid fever: therapeutic considerations. AU - Mishra,S, AU - Patwari,A K, AU - Anand,V K, AU - Pillai,P K, AU - Aneja,S, AU - Chandra,J, AU - Sharma,D, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 443 EP - 8 JF - Indian pediatrics JO - Indian Pediatr VL - 29 IS - 4 N2 - Forty six blood culture positive cases were studied during the current outbreak of multidrug resistant typhoid fever (MRTF). The present outbreak was caused by E1 phage type and organisms were resistant to all commonly used drugs for the treatment of typhoid fever, viz., chloramphenicol (78%), co-trimoxazole (76%) and ampicillin (68%). Treatment failures with chloramphenicol (45.5%) corroborated well with in vitro resistance. No treatment failure was seen with chloramphenicol and ceftriaxone, when these drugs were used in cases infected with sensitive strains. Among the alternative drugs used in cases with in vitro sensitivity, successful clinical response was seen with ceftriaxone (4/4) and cefotaxime (8/9) as compared to cephalexin (3/5) or a combination of cephalexin and furazolidone (9/12). SN - 0019-6061 UR - https://www.unboundmedicine.com/medline/citation/1506095/Multidrug_resistant_typhoid_fever:_therapeutic_considerations_ L2 - https://www.diseaseinfosearch.org/result/7276 DB - PRIME DP - Unbound Medicine ER -