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Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease.
J Gen Intern Med 2004; 19(4):380-9JG

Abstract

OBJECTIVE

To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.

DESIGN

Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.

MEASUREMENTS AND MAIN RESULTS

Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.

CONCLUSIONS

There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

Authors+Show Affiliations

Southern California Evidence-Based Practice Center, Rand Corporation, Santa Monica, California, USA. shekekke@rand.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, U.S. Gov't, P.H.S.
Review
Systematic Review

Language

eng

PubMed ID

15061748

Citation

Shekelle, Paul G., et al. "Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease." Journal of General Internal Medicine, vol. 19, no. 4, 2004, pp. 380-9.
Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med. 2004;19(4):380-9.
Shekelle, P. G., Morton, S. C., Jungvig, L. K., Udani, J., Spar, M., Tu, W., ... Hardy, M. (2004). Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. Journal of General Internal Medicine, 19(4), pp. 380-9.
Shekelle PG, et al. Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease. J Gen Intern Med. 2004;19(4):380-9. PubMed PMID: 15061748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. AU - Shekelle,Paul G, AU - Morton,Sally C, AU - Jungvig,Lara K, AU - Udani,Jay, AU - Spar,Myles, AU - Tu,Wenli, AU - J Suttorp,Marika, AU - Coulter,Ian, AU - Newberry,Sydne J, AU - Hardy,Mary, PY - 2004/4/6/pubmed PY - 2004/7/28/medline PY - 2004/4/6/entrez SP - 380 EP - 9 JF - Journal of general internal medicine JO - J Gen Intern Med VL - 19 IS - 4 N2 - OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease. DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified. MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively. CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes. SN - 0884-8734 UR - https://www.unboundmedicine.com/medline/citation/15061748/Effect_of_supplemental_vitamin_E_for_the_prevention_and_treatment_of_cardiovascular_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0884-8734&date=2004&volume=19&issue=4&spage=380 DB - PRIME DP - Unbound Medicine ER -