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A 2-year follow-up study of cigarette smoking and risk of dementia.
Eur J Neurol. 2004 Apr; 11(4):277-82.EJ

Abstract

The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2-year follow-up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagnosed with MMSE (Mini-Mental State Examination) and DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders). Participants were classified as never smokers, past smokers, and current smokers. During follow-up, we recorded incident cases of dementia. The association of smoking and dementia was investigated using proportional hazards regression analysis. A total of 121 incident cases of dementia were detected, of which 84 (69%) were Alzheimer's disease, 17 (14%) were vascular dementia, and 21(17%) were other dementia. Compared with never smokers, current smokers had an increased risk of Alzheimer's disease (RR = 2.72; 95% CI = 1.63-5.42) and vascular dementia (RR = 1.98; 95% CI = 1.53-3.12) adjusting for age, sex, education, blood pressure, and alcohol intake. Compared with light smokers, the adjusted risk of Alzheimer's disease was significantly increased among smokers with a medium level of exposure (RR = 2.56; 95% CI = 1.65-5.52), with an even higher risk of Alzheimer's disease in the heavy smoking group (RR = 3.03; 95% CI = 1.25-4.02). Smoking was associated with the risk of dementia. This study suggests that both smoking status and amount is associated with dementia.

Authors+Show Affiliations

Second Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China. dj941@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15061830

Citation

Juan, D, et al. "A 2-year Follow-up Study of Cigarette Smoking and Risk of Dementia." European Journal of Neurology, vol. 11, no. 4, 2004, pp. 277-82.
Juan D, Zhou DH, Li J, et al. A 2-year follow-up study of cigarette smoking and risk of dementia. Eur J Neurol. 2004;11(4):277-82.
Juan, D., Zhou, D. H., Li, J., Wang, J. Y., Gao, C., & Chen, M. (2004). A 2-year follow-up study of cigarette smoking and risk of dementia. European Journal of Neurology, 11(4), 277-82.
Juan D, et al. A 2-year Follow-up Study of Cigarette Smoking and Risk of Dementia. Eur J Neurol. 2004;11(4):277-82. PubMed PMID: 15061830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 2-year follow-up study of cigarette smoking and risk of dementia. AU - Juan,D, AU - Zhou,D H D, AU - Li,J, AU - Wang,J Y J, AU - Gao,C, AU - Chen,M, PY - 2004/4/6/pubmed PY - 2004/5/25/medline PY - 2004/4/6/entrez SP - 277 EP - 82 JF - European journal of neurology JO - Eur. J. Neurol. VL - 11 IS - 4 N2 - The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2-year follow-up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagnosed with MMSE (Mini-Mental State Examination) and DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders). Participants were classified as never smokers, past smokers, and current smokers. During follow-up, we recorded incident cases of dementia. The association of smoking and dementia was investigated using proportional hazards regression analysis. A total of 121 incident cases of dementia were detected, of which 84 (69%) were Alzheimer's disease, 17 (14%) were vascular dementia, and 21(17%) were other dementia. Compared with never smokers, current smokers had an increased risk of Alzheimer's disease (RR = 2.72; 95% CI = 1.63-5.42) and vascular dementia (RR = 1.98; 95% CI = 1.53-3.12) adjusting for age, sex, education, blood pressure, and alcohol intake. Compared with light smokers, the adjusted risk of Alzheimer's disease was significantly increased among smokers with a medium level of exposure (RR = 2.56; 95% CI = 1.65-5.52), with an even higher risk of Alzheimer's disease in the heavy smoking group (RR = 3.03; 95% CI = 1.25-4.02). Smoking was associated with the risk of dementia. This study suggests that both smoking status and amount is associated with dementia. SN - 1351-5101 UR - https://www.unboundmedicine.com/medline/citation/15061830/A_2_year_follow_up_study_of_cigarette_smoking_and_risk_of_dementia_ L2 - https://doi.org/10.1046/j.1468-1331.2003.00779.x DB - PRIME DP - Unbound Medicine ER -