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Treatment of migraine headache with botulinum toxin type A.
Facial Plast Surg Clin North Am 2003; 11(4):465-75FP

Abstract

Migraine is a common headache disorder with profound implications on patients' quality of life and the overall health care system. Traditional treatment options have been less than optimal and many migraine patients lack confidence in over-the-counter and prescribed medications. BTX-A has shown promise as an efficacious, well-tolerated, long-lasting preventive therapy. Completed placebo-controlled trials showed that BTX-A injections for migraine resulted in fewer headaches, reduced headache severity and duration, reduced migraine-associated symptoms, and reduced use of migraine medications. Because the administration of BTX-A is nonsystemic, reported adverse events have been rare and mild. Larger trials are currently underway to further evaluate BTX-A efficacy and to determine optimal dosing and injection sites. Based on the collective experience of clinicians in neurology, facial plastic surgery, and otolaryngology, as well as supporting evidence from completed and ongoing clinical trials and theorized mechanism of action, an effective BTX-A approach for treatment of migraine is emerging. With further refinement to its use as prophylactic therapy, BTX-A can potentially be a primary option for candidate migraine sufferers and prescribing clinicians.

Authors+Show Affiliations

Department of Head and Neck Surgery, University of California at Los Angeles School of Medicine, USA. WJBMD8@aol.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15062251

Citation

Binder, William J., and Andrew Blitzer. "Treatment of Migraine Headache With Botulinum Toxin Type A." Facial Plastic Surgery Clinics of North America, vol. 11, no. 4, 2003, pp. 465-75.
Binder WJ, Blitzer A. Treatment of migraine headache with botulinum toxin type A. Facial Plast Surg Clin North Am. 2003;11(4):465-75.
Binder, W. J., & Blitzer, A. (2003). Treatment of migraine headache with botulinum toxin type A. Facial Plastic Surgery Clinics of North America, 11(4), pp. 465-75.
Binder WJ, Blitzer A. Treatment of Migraine Headache With Botulinum Toxin Type A. Facial Plast Surg Clin North Am. 2003;11(4):465-75. PubMed PMID: 15062251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of migraine headache with botulinum toxin type A. AU - Binder,William J, AU - Blitzer,Andrew, PY - 2004/4/6/pubmed PY - 2004/7/15/medline PY - 2004/4/6/entrez SP - 465 EP - 75 JF - Facial plastic surgery clinics of North America JO - Facial Plast Surg Clin North Am VL - 11 IS - 4 N2 - Migraine is a common headache disorder with profound implications on patients' quality of life and the overall health care system. Traditional treatment options have been less than optimal and many migraine patients lack confidence in over-the-counter and prescribed medications. BTX-A has shown promise as an efficacious, well-tolerated, long-lasting preventive therapy. Completed placebo-controlled trials showed that BTX-A injections for migraine resulted in fewer headaches, reduced headache severity and duration, reduced migraine-associated symptoms, and reduced use of migraine medications. Because the administration of BTX-A is nonsystemic, reported adverse events have been rare and mild. Larger trials are currently underway to further evaluate BTX-A efficacy and to determine optimal dosing and injection sites. Based on the collective experience of clinicians in neurology, facial plastic surgery, and otolaryngology, as well as supporting evidence from completed and ongoing clinical trials and theorized mechanism of action, an effective BTX-A approach for treatment of migraine is emerging. With further refinement to its use as prophylactic therapy, BTX-A can potentially be a primary option for candidate migraine sufferers and prescribing clinicians. SN - 1064-7406 UR - https://www.unboundmedicine.com/medline/citation/15062251/Treatment_of_migraine_headache_with_botulinum_toxin_type_A_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064740603000762 DB - PRIME DP - Unbound Medicine ER -