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Cigar smoking has an acute detrimental effect on arterial stiffness.

Abstract

BACKGROUND

Despite a decline in cigarette smoking, cigar smoking is increasing, partly due to the perception that it is a "safe" alternative to cigarettes. However, cigar smoking increases cardiovascular risk, but the mechanisms involved are not fully explored. Aortic stiffness and arterial wave reflection are important factors for the efficient performance of the cardiovascular system and have been identified as prognosticators of cardiovascular risk. We investigated the acute effect of cigar smoking on aortic elastic properties and wave reflection.

METHODS

We studied the effect of smoking one cigar in 12 healthy subjects according to a randomized, sham procedure-controlled, cross-over design. Aortic stiffness was evaluated with carotid-femoral pulse wave velocity and wave reflection with augmentation index of the aortic pressure waveform.

RESULTS

Cigar smoking produced a significant increase in pulse wave velocity (by 0.80 m/sec, P = .001) denoting an increase in aortic stiffness. Augmentation index increased significantly (by 6.1%, P < .05) denoting an increase of wave reflections. These increases in arterial stiffness indices were evident promptly after the initiation of cigar smoking and lasted throughout the duration of the study (2 h). Concurrently, both radial and aortic systolic, and pulse pressure increased significantly throughout the study.

CONCLUSIONS

The present study shows for the first time that cigar smoking increases acutely stiffness of large arteries and wave reflection, thus providing further evidence that it is not a safe alternative to cigarettes.

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  • Authors+Show Affiliations

    ,

    Athens Medical School, Hippokration Hospital, Athens, Greece. cvlachop@otenet.gr

    , , ,

    Source

    American journal of hypertension 17:4 2004 Apr pg 299-303

    MeSH

    Adult
    Aortic Diseases
    Biomarkers
    Blood Flow Velocity
    Blood Pressure
    Carbon Monoxide
    Carotid Artery, Common
    Cross-Over Studies
    Diastole
    Femoral Artery
    Heart Rate
    Humans
    Male
    Smoking
    Systole
    Time Factors

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    15062882

    Citation

    Vlachopoulos, Charalambos, et al. "Cigar Smoking Has an Acute Detrimental Effect On Arterial Stiffness." American Journal of Hypertension, vol. 17, no. 4, 2004, pp. 299-303.
    Vlachopoulos C, Alexopoulos N, Panagiotakos D, et al. Cigar smoking has an acute detrimental effect on arterial stiffness. Am J Hypertens. 2004;17(4):299-303.
    Vlachopoulos, C., Alexopoulos, N., Panagiotakos, D., O'Rourke, M. F., & Stefanadis, C. (2004). Cigar smoking has an acute detrimental effect on arterial stiffness. American Journal of Hypertension, 17(4), pp. 299-303.
    Vlachopoulos C, et al. Cigar Smoking Has an Acute Detrimental Effect On Arterial Stiffness. Am J Hypertens. 2004;17(4):299-303. PubMed PMID: 15062882.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cigar smoking has an acute detrimental effect on arterial stiffness. AU - Vlachopoulos,Charalambos, AU - Alexopoulos,Nikolaos, AU - Panagiotakos,Demosthenes, AU - O'Rourke,Michael F, AU - Stefanadis,Christodoulos, PY - 2003/10/14/received PY - 2003/12/23/revised PY - 2003/12/23/accepted PY - 2004/4/6/pubmed PY - 2004/11/9/medline PY - 2004/4/6/entrez SP - 299 EP - 303 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 17 IS - 4 N2 - BACKGROUND: Despite a decline in cigarette smoking, cigar smoking is increasing, partly due to the perception that it is a "safe" alternative to cigarettes. However, cigar smoking increases cardiovascular risk, but the mechanisms involved are not fully explored. Aortic stiffness and arterial wave reflection are important factors for the efficient performance of the cardiovascular system and have been identified as prognosticators of cardiovascular risk. We investigated the acute effect of cigar smoking on aortic elastic properties and wave reflection. METHODS: We studied the effect of smoking one cigar in 12 healthy subjects according to a randomized, sham procedure-controlled, cross-over design. Aortic stiffness was evaluated with carotid-femoral pulse wave velocity and wave reflection with augmentation index of the aortic pressure waveform. RESULTS: Cigar smoking produced a significant increase in pulse wave velocity (by 0.80 m/sec, P = .001) denoting an increase in aortic stiffness. Augmentation index increased significantly (by 6.1%, P < .05) denoting an increase of wave reflections. These increases in arterial stiffness indices were evident promptly after the initiation of cigar smoking and lasted throughout the duration of the study (2 h). Concurrently, both radial and aortic systolic, and pulse pressure increased significantly throughout the study. CONCLUSIONS: The present study shows for the first time that cigar smoking increases acutely stiffness of large arteries and wave reflection, thus providing further evidence that it is not a safe alternative to cigarettes. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/15062882/Cigar_smoking_has_an_acute_detrimental_effect_on_arterial_stiffness_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2003.12.014 DB - PRIME DP - Unbound Medicine ER -