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Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine.
J Control Release. 2004 Apr 16; 96(1):9-20.JC

Abstract

Sequential interpenetrating network (IPN) of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were prepared and crosslinked with glutaraldehyde (GA) to form pH-sensitive microspheres by the water-in-oil (w/o) emulsification method. Microspheres were used to deliver a model anti-inflammatory drug, diclofenac sodium (DS), to the intestine. The formed IPN was analyzed by Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses were done on the drug-loaded microspheres to confirm the polymorphism of DS. Results indicated a molecular level dispersion of DS in the IPN. Microspheres formed were spherical with the smooth surfaces as evidenced by scanning electron microscopy (SEM). Particle size and size distribution was studied using laser light diffraction particle size analyzer. Particle size analysis was also done by optical microscope for the selected microspheres; the change in diameter of the microspheres when soaked in different media at different time intervals was measured by optical microscope. Microspheres showed a pulsatile swelling behavior when the pH of the swelling media was changed. The swelling data were fitted to an empirical equation to understand the phenomenon of water transport as well as to calculate the diffusion coefficient (D). Values of D in acidic media were lower than those found in basic media. The values of D decrease with increasing crosslinking of the matrix. In-vitro release studies have been performed in 1.2 and 7.4 pH media to simulate gastric and intestinal conditions. The results indicated a dependence on the pH of the release media, extent of crosslinking and the amount of drug loading.

Authors+Show Affiliations

Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad 580 003, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15063025

Citation

Kurkuri, Mahaveer D., and Tejraj M. Aminabhavi. "Poly(vinyl Alcohol) and Poly(acrylic Acid) Sequential Interpenetrating Network pH-sensitive Microspheres for the Delivery of Diclofenac Sodium to the Intestine." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 96, no. 1, 2004, pp. 9-20.
Kurkuri MD, Aminabhavi TM. Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J Control Release. 2004;96(1):9-20.
Kurkuri, M. D., & Aminabhavi, T. M. (2004). Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. Journal of Controlled Release : Official Journal of the Controlled Release Society, 96(1), 9-20.
Kurkuri MD, Aminabhavi TM. Poly(vinyl Alcohol) and Poly(acrylic Acid) Sequential Interpenetrating Network pH-sensitive Microspheres for the Delivery of Diclofenac Sodium to the Intestine. J Control Release. 2004 Apr 16;96(1):9-20. PubMed PMID: 15063025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. AU - Kurkuri,Mahaveer D, AU - Aminabhavi,Tejraj M, PY - 2003/05/11/received PY - 2003/12/18/accepted PY - 2004/4/6/pubmed PY - 2004/11/17/medline PY - 2004/4/6/entrez SP - 9 EP - 20 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 96 IS - 1 N2 - Sequential interpenetrating network (IPN) of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were prepared and crosslinked with glutaraldehyde (GA) to form pH-sensitive microspheres by the water-in-oil (w/o) emulsification method. Microspheres were used to deliver a model anti-inflammatory drug, diclofenac sodium (DS), to the intestine. The formed IPN was analyzed by Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses were done on the drug-loaded microspheres to confirm the polymorphism of DS. Results indicated a molecular level dispersion of DS in the IPN. Microspheres formed were spherical with the smooth surfaces as evidenced by scanning electron microscopy (SEM). Particle size and size distribution was studied using laser light diffraction particle size analyzer. Particle size analysis was also done by optical microscope for the selected microspheres; the change in diameter of the microspheres when soaked in different media at different time intervals was measured by optical microscope. Microspheres showed a pulsatile swelling behavior when the pH of the swelling media was changed. The swelling data were fitted to an empirical equation to understand the phenomenon of water transport as well as to calculate the diffusion coefficient (D). Values of D in acidic media were lower than those found in basic media. The values of D decrease with increasing crosslinking of the matrix. In-vitro release studies have been performed in 1.2 and 7.4 pH media to simulate gastric and intestinal conditions. The results indicated a dependence on the pH of the release media, extent of crosslinking and the amount of drug loading. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/15063025/Poly_vinyl_alcohol__and_poly_acrylic_acid__sequential_interpenetrating_network_pH_sensitive_microspheres_for_the_delivery_of_diclofenac_sodium_to_the_intestine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168365904000057 DB - PRIME DP - Unbound Medicine ER -