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Aqueous starch acetate dispersion as a novel coating material for controlled release products.
J Control Release. 2004 Apr 16; 96(1):179-91.JC

Abstract

The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.

Authors+Show Affiliations

Tarvainen M
Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. Maarit.Tarvainen@uku.fi
Peltonen S
No affiliation info available
Mikkonen H
No affiliation info available
Elovaara M
No affiliation info available
Tuunainen M
No affiliation info available
Paronen P
No affiliation info available
Ketolainen J
No affiliation info available
Sutinen R
No affiliation info available

MeSH

Coated Materials, BiocompatibleDelayed-Action PreparationsStarchWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15063040

Citation

Tarvainen, Maarit, et al. "Aqueous Starch Acetate Dispersion as a Novel Coating Material for Controlled Release Products." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 96, no. 1, 2004, pp. 179-91.
Tarvainen M, Peltonen S, Mikkonen H, et al. Aqueous starch acetate dispersion as a novel coating material for controlled release products. J Control Release. 2004;96(1):179-91.
Tarvainen, M., Peltonen, S., Mikkonen, H., Elovaara, M., Tuunainen, M., Paronen, P., Ketolainen, J., & Sutinen, R. (2004). Aqueous starch acetate dispersion as a novel coating material for controlled release products. Journal of Controlled Release : Official Journal of the Controlled Release Society, 96(1), 179-91.
Tarvainen M, et al. Aqueous Starch Acetate Dispersion as a Novel Coating Material for Controlled Release Products. J Control Release. 2004 Apr 16;96(1):179-91. PubMed PMID: 15063040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aqueous starch acetate dispersion as a novel coating material for controlled release products. AU - Tarvainen,Maarit, AU - Peltonen,Soili, AU - Mikkonen,Hannu, AU - Elovaara,Minna, AU - Tuunainen,Minna, AU - Paronen,Petteri, AU - Ketolainen,Jarkko, AU - Sutinen,Riitta, PY - 2003/11/12/received PY - 2004/01/22/accepted PY - 2004/4/6/pubmed PY - 2004/11/17/medline PY - 2004/4/6/entrez SP - 179 EP - 91 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 96 IS - 1 N2 - The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/15063040/Aqueous_starch_acetate_dispersion_as_a_novel_coating_material_for_controlled_release_products_ DB - PRIME DP - Unbound Medicine ER -