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The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters.
Environ Health Perspect. 2004 Apr; 112(5):538-41.EH

Abstract

Previous studies have suggested that delta-aminolevulinic acid dehydratase (ALAD) types 1-2 or 2-2 are protective against the toxicity of blood lead (PbB) when zinc protoporphyrin (ZPP) levels are low because of differential binding of lead in erythrocytes. The hypothesis is that subjects with the ALAD 1-1 genotype are more susceptible to lead exposure with impaired hematologic synthesis and therefore that iron nutrition is more important in those with the ALAD 1-1 genotype. The purpose of this study was to prove the protective effect of ALAD 1-2/2-2 against PbB with higher hematologic parameters. Data on 1,219 male workers from eight lead-using factories in the Republic of Korea were examined in this cross-sectional study. Blood samples were evaluated for PbB, ZPP, hemoglobin (Hb), and serum iron (SFe) concentrations and ALAD genotypes. The overall prevalence of the ALAD 1-2/2-2 genotype was 9.3%, which was associated with lower log ZPP (p < 0.001) and higher Hb (p = 0.014) levels. For the subjects with normal iron status (SFe levels > 60 micro g/dL), those with the ALAD 1-1 genotype were more likely to be anemic (adjusted odds ratio of 5.2; 95% confidence interval, 1.2-22.6) than those with ALAD 1-2/2-2. The study confirms the protective effects of ALAD 1-2/2-2 polymorphisms against PbB on hematologic pathways. In order to promote health and to minimize the toxicity of lead exposure more effectively, the nutritional management of iron in Korean workers should take both their ALAD genotypes and occupational lead exposures into account.

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Authors+Show Affiliations

Kim HS
Department of Food Science and Nutrition, Soonchunhyang University, Asan, Choongnam 336-745, Republic of Korea.
Lee SS
No affiliation info available
Lee GS
No affiliation info available
Hwangbo Y
No affiliation info available
Ahn KD
No affiliation info available
Lee BK
No affiliation info available

MeSH

AdultAgedAnemiaCross-Sectional StudiesGenotypeHemoglobinsHumansIsoenzymesLeadMaleMetallurgyMiddle AgedOccupational ExposurePorphobilinogen SynthaseProtoporphyrins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15064157

Citation

Kim, Hee-Seon, et al. "The Protective Effect of Delta-aminolevulinic Acid Dehydratase 1-2 and 2-2 Isozymes Against Blood Lead With Higher Hematologic Parameters." Environmental Health Perspectives, vol. 112, no. 5, 2004, pp. 538-41.
Kim HS, Lee SS, Lee GS, et al. The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters. Environ Health Perspect. 2004;112(5):538-41.
Kim, H. S., Lee, S. S., Lee, G. S., Hwangbo, Y., Ahn, K. D., & Lee, B. K. (2004). The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters. Environmental Health Perspectives, 112(5), 538-41.
Kim HS, et al. The Protective Effect of Delta-aminolevulinic Acid Dehydratase 1-2 and 2-2 Isozymes Against Blood Lead With Higher Hematologic Parameters. Environ Health Perspect. 2004;112(5):538-41. PubMed PMID: 15064157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters. AU - Kim,Hee-Seon, AU - Lee,Sung-Soo, AU - Lee,Gap-Soo, AU - Hwangbo,Young, AU - Ahn,Kyu-Dong, AU - Lee,Byung-Kook, PY - 2004/4/6/pubmed PY - 2004/11/13/medline PY - 2004/4/6/entrez SP - 538 EP - 41 JF - Environmental health perspectives JO - Environ Health Perspect VL - 112 IS - 5 N2 - Previous studies have suggested that delta-aminolevulinic acid dehydratase (ALAD) types 1-2 or 2-2 are protective against the toxicity of blood lead (PbB) when zinc protoporphyrin (ZPP) levels are low because of differential binding of lead in erythrocytes. The hypothesis is that subjects with the ALAD 1-1 genotype are more susceptible to lead exposure with impaired hematologic synthesis and therefore that iron nutrition is more important in those with the ALAD 1-1 genotype. The purpose of this study was to prove the protective effect of ALAD 1-2/2-2 against PbB with higher hematologic parameters. Data on 1,219 male workers from eight lead-using factories in the Republic of Korea were examined in this cross-sectional study. Blood samples were evaluated for PbB, ZPP, hemoglobin (Hb), and serum iron (SFe) concentrations and ALAD genotypes. The overall prevalence of the ALAD 1-2/2-2 genotype was 9.3%, which was associated with lower log ZPP (p < 0.001) and higher Hb (p = 0.014) levels. For the subjects with normal iron status (SFe levels > 60 micro g/dL), those with the ALAD 1-1 genotype were more likely to be anemic (adjusted odds ratio of 5.2; 95% confidence interval, 1.2-22.6) than those with ALAD 1-2/2-2. The study confirms the protective effects of ALAD 1-2/2-2 polymorphisms against PbB on hematologic pathways. In order to promote health and to minimize the toxicity of lead exposure more effectively, the nutritional management of iron in Korean workers should take both their ALAD genotypes and occupational lead exposures into account. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/15064157/The_protective_effect_of_delta_aminolevulinic_acid_dehydratase_1_2_and_2_2_isozymes_against_blood_lead_with_higher_hematologic_parameters_ DB - PRIME DP - Unbound Medicine ER -