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Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy.
Can J Anaesth. 2004 Apr; 51(4):358-63.CJ

Abstract

PURPOSE

To evaluate the comparative preemptive effects of gabapentin and tramadol on postoperative pain and fentanyl requirement in laparoscopic cholecystectomy.

METHODS

Four hundred fifty-nine ASA I and II patients were randomly assigned to receive 300 mg gabapentin, 100 mg tramadol or placebo in a double-blind manner two hours before laparoscopic cholecystectomy under general anesthesia. Postoperatively, patients' pain scores were recorded on a visual analogue scale every two hours for the initial 12 hr and thereafter every three hours for the next 12 hr. Patients received fentanyl 2 micro g*kg(-1) intravenously on demand. The total fentanyl consumption for each patient was recorded.

RESULTS

Patients in the gabapentin group had significantly lower pain scores at all time intervals (2.65 +/- 3.00, 1.99 +/- 1.48, 1.40 +/- 0.95, 0.65 +/- 0.61) in comparison to tramadol (2.97 +/- 2.35, 2.37 +/- 1.45, 1.89 +/- 1.16, 0.87 +/- 0.50) and placebo (5.53 +/- 2.22, 3.33 +/- 1.37, 2.41 +/- 1.19, 1.19 +/- 0.56). Significantly less fentanyl was consumed in the gabapentin group (221.16 +/- 52.39 micro g) than in the tramadol (269.60 +/- 44.17 micro g) and placebo groups (355.86 +/- 42.04 micro g; P < 0.05). Sedation (33.98%), nausea/retching/vomiting (24.8%) were the commonest side effects in the gabapentin group whereas respiratory depression (3.9%) was the commonest in the tramadol group and vertigo (7.8%) in the placebo group.

CONCLUSION

Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirement in laparoscopic cholecystectomy.

Links

Publisher Full Text

Authors+Show Affiliations

Pandey CK
Department of Anaesthesiology and Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. ckpandy@sgpgi.ac.in
Priye S
No affiliation info available
Singh S
No affiliation info available
Singh U
No affiliation info available
Singh RB
No affiliation info available
Singh PK
No affiliation info available

MeSH

AcetatesAdultAminesAnalgesiaAnalgesicsAnalgesics, OpioidAnalysis of VarianceAnesthetics, IntravenousCholecystectomyCyclohexanecarboxylic AcidsDouble-Blind MethodFemaleFentanylGabapentinHumansLaparoscopyMalePain MeasurementPain, PostoperativeTime FactorsTramadolTreatment Outcomegamma-Aminobutyric Acid

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15064265

Citation

Pandey, Chandra Kant, et al. "Preemptive Use of Gabapentin Significantly Decreases Postoperative Pain and Rescue Analgesic Requirements in Laparoscopic Cholecystectomy." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 51, no. 4, 2004, pp. 358-63.
Pandey CK, Priye S, Singh S, et al. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anaesth. 2004;51(4):358-63.
Pandey, C. K., Priye, S., Singh, S., Singh, U., Singh, R. B., & Singh, P. K. (2004). Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 51(4), 358-63.
Pandey CK, et al. Preemptive Use of Gabapentin Significantly Decreases Postoperative Pain and Rescue Analgesic Requirements in Laparoscopic Cholecystectomy. Can J Anaesth. 2004;51(4):358-63. PubMed PMID: 15064265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. AU - Pandey,Chandra Kant, AU - Priye,Shio, AU - Singh,Surendra, AU - Singh,Uttam, AU - Singh,Ram Badan, AU - Singh,Prabhat Kumar, PY - 2004/4/6/pubmed PY - 2004/10/8/medline PY - 2004/4/6/entrez SP - 358 EP - 63 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 51 IS - 4 N2 - PURPOSE: To evaluate the comparative preemptive effects of gabapentin and tramadol on postoperative pain and fentanyl requirement in laparoscopic cholecystectomy. METHODS: Four hundred fifty-nine ASA I and II patients were randomly assigned to receive 300 mg gabapentin, 100 mg tramadol or placebo in a double-blind manner two hours before laparoscopic cholecystectomy under general anesthesia. Postoperatively, patients' pain scores were recorded on a visual analogue scale every two hours for the initial 12 hr and thereafter every three hours for the next 12 hr. Patients received fentanyl 2 micro g*kg(-1) intravenously on demand. The total fentanyl consumption for each patient was recorded. RESULTS: Patients in the gabapentin group had significantly lower pain scores at all time intervals (2.65 +/- 3.00, 1.99 +/- 1.48, 1.40 +/- 0.95, 0.65 +/- 0.61) in comparison to tramadol (2.97 +/- 2.35, 2.37 +/- 1.45, 1.89 +/- 1.16, 0.87 +/- 0.50) and placebo (5.53 +/- 2.22, 3.33 +/- 1.37, 2.41 +/- 1.19, 1.19 +/- 0.56). Significantly less fentanyl was consumed in the gabapentin group (221.16 +/- 52.39 micro g) than in the tramadol (269.60 +/- 44.17 micro g) and placebo groups (355.86 +/- 42.04 micro g; P < 0.05). Sedation (33.98%), nausea/retching/vomiting (24.8%) were the commonest side effects in the gabapentin group whereas respiratory depression (3.9%) was the commonest in the tramadol group and vertigo (7.8%) in the placebo group. CONCLUSION: Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirement in laparoscopic cholecystectomy. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/15064265/Preemptive_use_of_gabapentin_significantly_decreases_postoperative_pain_and_rescue_analgesic_requirements_in_laparoscopic_cholecystectomy_ L2 - https://doi.org/10.1007/BF03018240 DB - PRIME DP - Unbound Medicine ER -