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Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions?
Ultrasound Obstet Gynecol. 2004 Apr; 23(4):393-7.UO

Abstract

OBJECTIVE

The use of three-dimensional (3D) ultrasound may help to determine the exact position of the needle during breast biopsy, thereby reducing the number of core samples that are needed to achieve a reliable histological diagnosis. The aim of this study was to demonstrate the efficacy of 3D ultrasound-validated large-core needle biopsy (LCNB) of the breast.

METHODS

A total of 360 core needle biopsies was obtained from 169 breast lesions in 146 patients. Additional open breast biopsy was performed in 111 women (127/169 breast lesions); the remaining 42 lesions were followed up for at least 24 months. 3D ultrasound visualization of the needle in the postfiring position was used to classify the biopsy as central, marginal or outside the lesion. Based on this classification it was decided whether another sample had to be obtained.

RESULTS

A median of two core samples per lesion provided for all the lesions a sensitivity for malignancy of 96.9%, specificity of 100%, false-positive rate of 0% and false-negative rate of 3.1%, and for the excised lesions a sensitivity of 96.5%, specificity of 100%, false-positive rate of 0%, false-negative rate of 3.5% and an underestimation rate of 3.4%.

CONCLUSIONS

3D ultrasound validation of the postfiring needle position is an efficient adjunct to ultrasound-guided LCNB. The advantages of 3D ultrasound validation are likely to include a reduction in the number of core samples needed to achieve a reliable histological diagnosis (and a possible reduction in the risk of tumor cell displacement), reduced procedure time and lower costs.

Authors+Show Affiliations

Centre for Ultrasound and Prenatal Diagnosis, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany. loredana.delle-chiaie@web.deNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15065192

Citation

Delle Chiaie, L, and R Terinde. "Three-dimensional Ultrasound-validated Large-core Needle Biopsy: Is It a Reliable Method for the Histological Assessment of Breast Lesions?" Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 23, no. 4, 2004, pp. 393-7.
Delle Chiaie L, Terinde R. Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions? Ultrasound Obstet Gynecol. 2004;23(4):393-7.
Delle Chiaie, L., & Terinde, R. (2004). Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions? Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 23(4), 393-7.
Delle Chiaie L, Terinde R. Three-dimensional Ultrasound-validated Large-core Needle Biopsy: Is It a Reliable Method for the Histological Assessment of Breast Lesions. Ultrasound Obstet Gynecol. 2004;23(4):393-7. PubMed PMID: 15065192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions? AU - Delle Chiaie,L, AU - Terinde,R, PY - 2004/4/6/pubmed PY - 2004/8/24/medline PY - 2004/4/6/entrez SP - 393 EP - 7 JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JO - Ultrasound Obstet Gynecol VL - 23 IS - 4 N2 - OBJECTIVE: The use of three-dimensional (3D) ultrasound may help to determine the exact position of the needle during breast biopsy, thereby reducing the number of core samples that are needed to achieve a reliable histological diagnosis. The aim of this study was to demonstrate the efficacy of 3D ultrasound-validated large-core needle biopsy (LCNB) of the breast. METHODS: A total of 360 core needle biopsies was obtained from 169 breast lesions in 146 patients. Additional open breast biopsy was performed in 111 women (127/169 breast lesions); the remaining 42 lesions were followed up for at least 24 months. 3D ultrasound visualization of the needle in the postfiring position was used to classify the biopsy as central, marginal or outside the lesion. Based on this classification it was decided whether another sample had to be obtained. RESULTS: A median of two core samples per lesion provided for all the lesions a sensitivity for malignancy of 96.9%, specificity of 100%, false-positive rate of 0% and false-negative rate of 3.1%, and for the excised lesions a sensitivity of 96.5%, specificity of 100%, false-positive rate of 0%, false-negative rate of 3.5% and an underestimation rate of 3.4%. CONCLUSIONS: 3D ultrasound validation of the postfiring needle position is an efficient adjunct to ultrasound-guided LCNB. The advantages of 3D ultrasound validation are likely to include a reduction in the number of core samples needed to achieve a reliable histological diagnosis (and a possible reduction in the risk of tumor cell displacement), reduced procedure time and lower costs. SN - 0960-7692 UR - https://www.unboundmedicine.com/medline/citation/15065192/Three_dimensional_ultrasound_validated_large_core_needle_biopsy:_is_it_a_reliable_method_for_the_histological_assessment_of_breast_lesions L2 - https://doi.org/10.1002/uog.1001 DB - PRIME DP - Unbound Medicine ER -