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Neuropsychological markers of dementia in patients with memory complaints.
Int J Geriatr Psychiatry. 2004 Apr; 19(4):352-8.IJ

Abstract

OBJECTIVES

To identify neuropsychological markers able to predict evolution towards dementia, through the detection of differential neuropsychological characteristics in a group of subjects complaining of memory loss, in a longitudinal, two-year follow-up study.

METHODS

Longitudinal and retrospective comparisons of neuropsychological performance in: (a) subjects complaining of memory loss who, after a two-year period, met neurological and clinical diagnostic criteria for probable AD, and (b) subjects from the same group who did not progress towards dementia. A sample of 43 subjects were administered a comprehensive neuropsychological battery evaluating orientation, logical-verbal and visuoperceptive reasoning, immediate and delayed verbal and visual memory, attention, learning, executive functions and semantic and phonemic verbal fluency.

RESULTS

Of the 43 subjects evaluated and then re-evaluated two years later, ten (23%) progressed to dementia according to the NINCS-ADRDA criteria for probable Alzheimer's disease. The neuropsychological performance of the rest of the subjects (n=33) over the two examinations was stable. In the retrospective analysis the principal differences between the two groups were found in the intensity of the initial memory deficits (WMS-R) and in the impairment of other cognitive areas in the dementia group: formation of concepts, vocabulary and similarities (WAIS), learning (WMS-R) and several executive functions.

CONCLUSIONS

The deficits in cognitive areas other than memory are significant in subjects with memory complaints who progress towards dementia within two years. Memory complaints represent a risk factor that is at least as important as actual memory loss. Recent proposals for adding descriptive labels to the diagnosis of Mild Cognitive Impairment (MCI) in order to reflect the neuropsychological functions impaired in addition to memory (Petersen, 2001a), may be decisive from the prognostic viewpoint.

Authors+Show Affiliations

Clinical Institute of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain. jguarch@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15065228

Citation

Guarch, J, et al. "Neuropsychological Markers of Dementia in Patients With Memory Complaints." International Journal of Geriatric Psychiatry, vol. 19, no. 4, 2004, pp. 352-8.
Guarch J, Marcos T, Salamero M, et al. Neuropsychological markers of dementia in patients with memory complaints. Int J Geriatr Psychiatry. 2004;19(4):352-8.
Guarch, J., Marcos, T., Salamero, M., & Blesa, R. (2004). Neuropsychological markers of dementia in patients with memory complaints. International Journal of Geriatric Psychiatry, 19(4), 352-8.
Guarch J, et al. Neuropsychological Markers of Dementia in Patients With Memory Complaints. Int J Geriatr Psychiatry. 2004;19(4):352-8. PubMed PMID: 15065228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological markers of dementia in patients with memory complaints. AU - Guarch,J, AU - Marcos,T, AU - Salamero,M, AU - Blesa,R, PY - 2004/4/6/pubmed PY - 2004/6/25/medline PY - 2004/4/6/entrez SP - 352 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 19 IS - 4 N2 - OBJECTIVES: To identify neuropsychological markers able to predict evolution towards dementia, through the detection of differential neuropsychological characteristics in a group of subjects complaining of memory loss, in a longitudinal, two-year follow-up study. METHODS: Longitudinal and retrospective comparisons of neuropsychological performance in: (a) subjects complaining of memory loss who, after a two-year period, met neurological and clinical diagnostic criteria for probable AD, and (b) subjects from the same group who did not progress towards dementia. A sample of 43 subjects were administered a comprehensive neuropsychological battery evaluating orientation, logical-verbal and visuoperceptive reasoning, immediate and delayed verbal and visual memory, attention, learning, executive functions and semantic and phonemic verbal fluency. RESULTS: Of the 43 subjects evaluated and then re-evaluated two years later, ten (23%) progressed to dementia according to the NINCS-ADRDA criteria for probable Alzheimer's disease. The neuropsychological performance of the rest of the subjects (n=33) over the two examinations was stable. In the retrospective analysis the principal differences between the two groups were found in the intensity of the initial memory deficits (WMS-R) and in the impairment of other cognitive areas in the dementia group: formation of concepts, vocabulary and similarities (WAIS), learning (WMS-R) and several executive functions. CONCLUSIONS: The deficits in cognitive areas other than memory are significant in subjects with memory complaints who progress towards dementia within two years. Memory complaints represent a risk factor that is at least as important as actual memory loss. Recent proposals for adding descriptive labels to the diagnosis of Mild Cognitive Impairment (MCI) in order to reflect the neuropsychological functions impaired in addition to memory (Petersen, 2001a), may be decisive from the prognostic viewpoint. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/15065228/Neuropsychological_markers_of_dementia_in_patients_with_memory_complaints_ L2 - https://doi.org/10.1002/gps.1074 DB - PRIME DP - Unbound Medicine ER -