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Additive preventive effect of influenza and pneumococcal vaccines in elderly persons.

Abstract

In 1999, all individuals > or = 65 yrs of age (n=258,754) in Stockholm County, Sweden, were offered influenza and pneumococcal vaccination in a prospective study on the effectiveness of these vaccines in reducing the need for hospital treatment and death due to influenza, pneumonia and invasive pneumococcal disease (IPD). Data on hospitalisation and mortality during 1 yr were obtained from the administrative database in Stockholm County Council. Vaccination was performed in 124,702 (48%) subjects; 72,107 had both vaccines, 29,346 only had the influenza vaccine and 23,249 only had the pneumococcal vaccine. Compared with the unvaccinated cohort, a lower incidence of hospitalisation for all endpoint diagnoses was seen in vaccinated persons. An additive effectiveness of vaccination was seen when both vaccines were given, with a reduction of hospital admissions for influenza (37%), pneumonia (29%) and IPD (44%). In-hospital mortality for pneumonia was significantly lower in those who received both vaccines, than in unvaccinated persons. To conclude, vaccination with influenza and pneumococcal vaccines together was effective in reducing the need for hospital admission for influenza and pneumonia. There was a strong indication that pneumococcal vaccination alone, was effective not only in the prevention of invasive pneumococcal disease, but also of pneumonia overall, although to a low degree.

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  • Authors+Show Affiliations

    ,

    Dept of Communicable Disease Control and Prevention, Stockholm County, Sweden.

    , ,

    Source

    The European respiratory journal 23:3 2004 Mar pg 363-8

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Cohort Studies
    Female
    Hospital Mortality
    Hospitalization
    Humans
    Incidence
    Influenza Vaccines
    Influenza, Human
    Male
    Pneumococcal Infections
    Pneumococcal Vaccines
    Pneumonia, Pneumococcal
    Prospective Studies
    Sweden
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15065822

    Citation

    Christenson, B, et al. "Additive Preventive Effect of Influenza and Pneumococcal Vaccines in Elderly Persons." The European Respiratory Journal, vol. 23, no. 3, 2004, pp. 363-8.
    Christenson B, Hedlund J, Lundbergh P, et al. Additive preventive effect of influenza and pneumococcal vaccines in elderly persons. Eur Respir J. 2004;23(3):363-8.
    Christenson, B., Hedlund, J., Lundbergh, P., & Ortqvist, A. (2004). Additive preventive effect of influenza and pneumococcal vaccines in elderly persons. The European Respiratory Journal, 23(3), pp. 363-8.
    Christenson B, et al. Additive Preventive Effect of Influenza and Pneumococcal Vaccines in Elderly Persons. Eur Respir J. 2004;23(3):363-8. PubMed PMID: 15065822.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Additive preventive effect of influenza and pneumococcal vaccines in elderly persons. AU - Christenson,B, AU - Hedlund,J, AU - Lundbergh,P, AU - Ortqvist,A, PY - 2004/4/7/pubmed PY - 2004/6/18/medline PY - 2004/4/7/entrez SP - 363 EP - 8 JF - The European respiratory journal JO - Eur. Respir. J. VL - 23 IS - 3 N2 - In 1999, all individuals > or = 65 yrs of age (n=258,754) in Stockholm County, Sweden, were offered influenza and pneumococcal vaccination in a prospective study on the effectiveness of these vaccines in reducing the need for hospital treatment and death due to influenza, pneumonia and invasive pneumococcal disease (IPD). Data on hospitalisation and mortality during 1 yr were obtained from the administrative database in Stockholm County Council. Vaccination was performed in 124,702 (48%) subjects; 72,107 had both vaccines, 29,346 only had the influenza vaccine and 23,249 only had the pneumococcal vaccine. Compared with the unvaccinated cohort, a lower incidence of hospitalisation for all endpoint diagnoses was seen in vaccinated persons. An additive effectiveness of vaccination was seen when both vaccines were given, with a reduction of hospital admissions for influenza (37%), pneumonia (29%) and IPD (44%). In-hospital mortality for pneumonia was significantly lower in those who received both vaccines, than in unvaccinated persons. To conclude, vaccination with influenza and pneumococcal vaccines together was effective in reducing the need for hospital admission for influenza and pneumonia. There was a strong indication that pneumococcal vaccination alone, was effective not only in the prevention of invasive pneumococcal disease, but also of pneumonia overall, although to a low degree. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/15065822/Additive_preventive_effect_of_influenza_and_pneumococcal_vaccines_in_elderly_persons_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=15065822 DB - PRIME DP - Unbound Medicine ER -