Tags

Type your tag names separated by a space and hit enter

Dietary palmitic and oleic acids exert similar effects on serum cholesterol and lipoprotein profiles in normocholesterolemic men and women.
J Am Coll Nutr 1992; 11(4):383-90JA

Abstract

To compare the effects of dietary palmitic acid (16:0) vs oleic acid (18:1) on serum lipids, lipoproteins, and plasma eicosanoids, 33 normocholesterolemic subjects (20 males, 13 females; ages 22-41 years) were challenged with a coconut oil-rich diet for 4 weeks. Subsequently they were assigned to either a palm olein-rich or olive oil-rich diet followed by a dietary crossover during two consecutive 6-week periods. Each test oil served as the sole cooking oil and contributed 23% of dietary energy or two-thirds of the total daily fat intake. Dietary myristic acid (14:0) and lauric acid (12:0) from coconut oil significantly raised all the serum lipid and lipoprotein parameters measured. Subsequent one-to-one exchange of 7% energy between 16:0 (palm olein diet) and 18:1 (olive oil diet) resulted in identical serum total cholesterol (192, 193 mg/dl), low-density lipoprotein cholesterol (LDL-C) (130, 131 mg/dl), high-density lipoprotein cholesterol (HDL-C) (41, 42 mg/dl), and triglyceride (TG) (108, 106 mg/dl) concentrations. Effects attributed to gender included higher HDL in females and higher TG in males associated with the tendency for higher LDL and LDL/HDL ratios in men. However, both sexes were equally responsive to changes in dietary fat saturation. The results indicate that in healthy, normocholesterolemic humans, dietary 16:0 can be exchanged for 18:1 within the range of these fatty acids normally present in typical diets without affecting the serum lipoprotein cholesterol concentration or distribution. In addition, replacement of 12:0 + 14:0 by 16:0 + 18:1, but especially 16:0 or some component of palm olein, appeared to have a beneficial impact on an important index of thrombogenesis, i.e., the thromboxane/prostacyclin ratio in plasma.

Authors+Show Affiliations

Institute for Medical Research, Kuala Lumpur, Malyasia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1506599

Citation

Ng, T K., et al. "Dietary Palmitic and Oleic Acids Exert Similar Effects On Serum Cholesterol and Lipoprotein Profiles in Normocholesterolemic Men and Women." Journal of the American College of Nutrition, vol. 11, no. 4, 1992, pp. 383-90.
Ng TK, Hayes KC, DeWitt GF, et al. Dietary palmitic and oleic acids exert similar effects on serum cholesterol and lipoprotein profiles in normocholesterolemic men and women. J Am Coll Nutr. 1992;11(4):383-90.
Ng, T. K., Hayes, K. C., DeWitt, G. F., Jegathesan, M., Satgunasingam, N., Ong, A. S., & Tan, D. (1992). Dietary palmitic and oleic acids exert similar effects on serum cholesterol and lipoprotein profiles in normocholesterolemic men and women. Journal of the American College of Nutrition, 11(4), pp. 383-90.
Ng TK, et al. Dietary Palmitic and Oleic Acids Exert Similar Effects On Serum Cholesterol and Lipoprotein Profiles in Normocholesterolemic Men and Women. J Am Coll Nutr. 1992;11(4):383-90. PubMed PMID: 1506599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary palmitic and oleic acids exert similar effects on serum cholesterol and lipoprotein profiles in normocholesterolemic men and women. AU - Ng,T K, AU - Hayes,K C, AU - DeWitt,G F, AU - Jegathesan,M, AU - Satgunasingam,N, AU - Ong,A S, AU - Tan,D, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 383 EP - 90 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 11 IS - 4 N2 - To compare the effects of dietary palmitic acid (16:0) vs oleic acid (18:1) on serum lipids, lipoproteins, and plasma eicosanoids, 33 normocholesterolemic subjects (20 males, 13 females; ages 22-41 years) were challenged with a coconut oil-rich diet for 4 weeks. Subsequently they were assigned to either a palm olein-rich or olive oil-rich diet followed by a dietary crossover during two consecutive 6-week periods. Each test oil served as the sole cooking oil and contributed 23% of dietary energy or two-thirds of the total daily fat intake. Dietary myristic acid (14:0) and lauric acid (12:0) from coconut oil significantly raised all the serum lipid and lipoprotein parameters measured. Subsequent one-to-one exchange of 7% energy between 16:0 (palm olein diet) and 18:1 (olive oil diet) resulted in identical serum total cholesterol (192, 193 mg/dl), low-density lipoprotein cholesterol (LDL-C) (130, 131 mg/dl), high-density lipoprotein cholesterol (HDL-C) (41, 42 mg/dl), and triglyceride (TG) (108, 106 mg/dl) concentrations. Effects attributed to gender included higher HDL in females and higher TG in males associated with the tendency for higher LDL and LDL/HDL ratios in men. However, both sexes were equally responsive to changes in dietary fat saturation. The results indicate that in healthy, normocholesterolemic humans, dietary 16:0 can be exchanged for 18:1 within the range of these fatty acids normally present in typical diets without affecting the serum lipoprotein cholesterol concentration or distribution. In addition, replacement of 12:0 + 14:0 by 16:0 + 18:1, but especially 16:0 or some component of palm olein, appeared to have a beneficial impact on an important index of thrombogenesis, i.e., the thromboxane/prostacyclin ratio in plasma. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/1506599/Dietary_palmitic_and_oleic_acids_exert_similar_effects_on_serum_cholesterol_and_lipoprotein_profiles_in_normocholesterolemic_men_and_women_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.1992.10718241 DB - PRIME DP - Unbound Medicine ER -