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Increases in serum non-high-density lipoprotein cholesterol may be beneficial in some high-functioning older adults: MacArthur studies of successful aging.
J Am Geriatr Soc. 2004 Apr; 52(4):487-94.JA

Abstract

objectives: To examine the association between changes in serum non-high-density lipoprotein cholesterol (non-HDL-C) over a 2.5-year period and risk of adverse health outcomes in the following 4.5 years in high-functioning older adults.

DESIGN

Prospective cohort, established in 1988, with a follow-up in 1991 and 1995.

SETTING

Population-based, community-dwelling men and women.

PARTICIPANTS

A random sample (n=267) from the MacArthur cohort (N=1,189). The cohort represented the highest-functioning tertile of 4,030 screened candidates aged 70 to 79.

MEASUREMENTS

Change in non-HDL-C between 1988 and 1991 was measured as a predictor of health outcomes between 1991 and 1995, including all-cause mortality, and among survivors, incident heart attack or stroke, development of new disability in basic activities of daily living, and decline in performance on the Short Portable Mental Status Questionnaire.

RESULTS

More-positive change in non-HDL-C between 1988 and 1991 was associated with fewer adverse outcomes between 1991 and 1995. In individuals whose total cholesterol at baseline was in the middle two quartiles (195-244 mg/dL), each 10-mg/dL increase in the 1988-to-1991 change in non-HDL-C was associated with an adjusted mortality odds ratio (OR) of 0.67 (95% confidence interval (CI)=0.51-0.88). In individuals without cardiovascular disease at baseline, the adjusted OR for new physical disability was 0.79 (95% CI=0.65-0.95) and for cognitive decline was 0.81 (95% CI=0.67-0.98).

CONCLUSION

Increases in cholesterol over time have beneficial associations in some older adults. The role of cholesterol changes in the health of older individuals needs further exploration.

Authors+Show Affiliations

Division of Geriatrics, Department of Medicine, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA. akarlamagla@mednet.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15066061

Citation

Karlamangla, Arun S., et al. "Increases in Serum Non-high-density Lipoprotein Cholesterol May Be Beneficial in some High-functioning Older Adults: MacArthur Studies of Successful Aging." Journal of the American Geriatrics Society, vol. 52, no. 4, 2004, pp. 487-94.
Karlamangla AS, Singer BH, Reuben DB, et al. Increases in serum non-high-density lipoprotein cholesterol may be beneficial in some high-functioning older adults: MacArthur studies of successful aging. J Am Geriatr Soc. 2004;52(4):487-94.
Karlamangla, A. S., Singer, B. H., Reuben, D. B., & Seeman, T. E. (2004). Increases in serum non-high-density lipoprotein cholesterol may be beneficial in some high-functioning older adults: MacArthur studies of successful aging. Journal of the American Geriatrics Society, 52(4), 487-94.
Karlamangla AS, et al. Increases in Serum Non-high-density Lipoprotein Cholesterol May Be Beneficial in some High-functioning Older Adults: MacArthur Studies of Successful Aging. J Am Geriatr Soc. 2004;52(4):487-94. PubMed PMID: 15066061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increases in serum non-high-density lipoprotein cholesterol may be beneficial in some high-functioning older adults: MacArthur studies of successful aging. AU - Karlamangla,Arun S, AU - Singer,Burton H, AU - Reuben,David B, AU - Seeman,Teresa E, PY - 2004/4/7/pubmed PY - 2004/5/14/medline PY - 2004/4/7/entrez SP - 487 EP - 94 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 52 IS - 4 N2 - UNLABELLED: objectives: To examine the association between changes in serum non-high-density lipoprotein cholesterol (non-HDL-C) over a 2.5-year period and risk of adverse health outcomes in the following 4.5 years in high-functioning older adults. DESIGN: Prospective cohort, established in 1988, with a follow-up in 1991 and 1995. SETTING: Population-based, community-dwelling men and women. PARTICIPANTS: A random sample (n=267) from the MacArthur cohort (N=1,189). The cohort represented the highest-functioning tertile of 4,030 screened candidates aged 70 to 79. MEASUREMENTS: Change in non-HDL-C between 1988 and 1991 was measured as a predictor of health outcomes between 1991 and 1995, including all-cause mortality, and among survivors, incident heart attack or stroke, development of new disability in basic activities of daily living, and decline in performance on the Short Portable Mental Status Questionnaire. RESULTS: More-positive change in non-HDL-C between 1988 and 1991 was associated with fewer adverse outcomes between 1991 and 1995. In individuals whose total cholesterol at baseline was in the middle two quartiles (195-244 mg/dL), each 10-mg/dL increase in the 1988-to-1991 change in non-HDL-C was associated with an adjusted mortality odds ratio (OR) of 0.67 (95% confidence interval (CI)=0.51-0.88). In individuals without cardiovascular disease at baseline, the adjusted OR for new physical disability was 0.79 (95% CI=0.65-0.95) and for cognitive decline was 0.81 (95% CI=0.67-0.98). CONCLUSION: Increases in cholesterol over time have beneficial associations in some older adults. The role of cholesterol changes in the health of older individuals needs further exploration. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/15066061/Increases_in_serum_non_high_density_lipoprotein_cholesterol_may_be_beneficial_in_some_high_functioning_older_adults:_MacArthur_studies_of_successful_aging_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2004&volume=52&issue=4&spage=487 DB - PRIME DP - Unbound Medicine ER -