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Alcohol intake and risk of dementia.

Abstract

OBJECTIVES

To examine the association between intake of alcoholic beverages and risk of Alzheimer's disease (AD) and dementia associated with stroke (DAS) in a cohort of elderly persons from New York City.

DESIGN

Cohort study.

SETTING

The Washington Heights Inwood-Columbia Aging Project.

PARTICIPANTS

Nine hundred eighty community-dwelling individuals aged 65 and older without dementia at baseline and with data on alcohol intake recruited between 1991 and 1996 and followed annually.

MEASUREMENTS

Intake of alcohol was measured using a semiquantitative food frequency questionnaire at baseline. Subjects were followed annually, and incident dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria and classified as AD or DAS.

RESULTS

After 4 years of follow-up, 260 individuals developed dementia (199 AD, 61 DAS). After adjusting for age, sex, apolipoprotein E (APOE)-epsilon 4 status, education, and other alcoholic beverages, only intake of up to three daily servings of wine was associated with a lower risk of AD (hazard ratio=0.55, 95% confidence interval=0.34-0.89). Intake of liquor, beer, and total alcohol was not associated with a lower risk of AD. Stratified analyses by the APOE-epsilon 4 allele revealed that the association between wine consumption and lower risk of AD was confined to individuals without the APOE-epsilon 4 allele.

CONCLUSIONS

Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele.

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  • Authors+Show Affiliations

    ,

    Taub Institute for Research of Alzheimer's Disease and the Aging Brain, and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

    , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alcohol Drinking
    Alzheimer Disease
    Apolipoprotein E4
    Apolipoproteins E
    Beer
    Chi-Square Distribution
    Dementia
    Diet Surveys
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Multivariate Analysis
    New York City
    Population Surveillance
    Proportional Hazards Models
    Risk Factors
    Stroke
    Surveys and Questionnaires
    Urban Population
    Wine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15066068

    Citation

    Luchsinger, Jose A., et al. "Alcohol Intake and Risk of Dementia." Journal of the American Geriatrics Society, vol. 52, no. 4, 2004, pp. 540-6.
    Luchsinger JA, Tang MX, Siddiqui M, et al. Alcohol intake and risk of dementia. J Am Geriatr Soc. 2004;52(4):540-6.
    Luchsinger, J. A., Tang, M. X., Siddiqui, M., Shea, S., & Mayeux, R. (2004). Alcohol intake and risk of dementia. Journal of the American Geriatrics Society, 52(4), pp. 540-6.
    Luchsinger JA, et al. Alcohol Intake and Risk of Dementia. J Am Geriatr Soc. 2004;52(4):540-6. PubMed PMID: 15066068.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol intake and risk of dementia. AU - Luchsinger,Jose A, AU - Tang,Ming-Xin, AU - Siddiqui,Maliha, AU - Shea,Steven, AU - Mayeux,Richard, PY - 2004/4/7/pubmed PY - 2004/5/14/medline PY - 2004/4/7/entrez SP - 540 EP - 6 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 52 IS - 4 N2 - OBJECTIVES: To examine the association between intake of alcoholic beverages and risk of Alzheimer's disease (AD) and dementia associated with stroke (DAS) in a cohort of elderly persons from New York City. DESIGN: Cohort study. SETTING: The Washington Heights Inwood-Columbia Aging Project. PARTICIPANTS: Nine hundred eighty community-dwelling individuals aged 65 and older without dementia at baseline and with data on alcohol intake recruited between 1991 and 1996 and followed annually. MEASUREMENTS: Intake of alcohol was measured using a semiquantitative food frequency questionnaire at baseline. Subjects were followed annually, and incident dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria and classified as AD or DAS. RESULTS: After 4 years of follow-up, 260 individuals developed dementia (199 AD, 61 DAS). After adjusting for age, sex, apolipoprotein E (APOE)-epsilon 4 status, education, and other alcoholic beverages, only intake of up to three daily servings of wine was associated with a lower risk of AD (hazard ratio=0.55, 95% confidence interval=0.34-0.89). Intake of liquor, beer, and total alcohol was not associated with a lower risk of AD. Stratified analyses by the APOE-epsilon 4 allele revealed that the association between wine consumption and lower risk of AD was confined to individuals without the APOE-epsilon 4 allele. CONCLUSIONS: Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/15066068/Alcohol_intake_and_risk_of_dementia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2004&volume=52&issue=4&spage=540 DB - PRIME DP - Unbound Medicine ER -