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Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats.
Eur J Neurosci. 2004 Mar; 19(6):1661-7.EJ

Abstract

Stimuli paired with cocaine can maintain cocaine-seeking as conditioned reinforcers. Although converging evidence implicates a role for the ventral tegmental area (VTA) in the primary reinforcing effects of drugs of abuse, the role of the VTA in mediating associative influences over drug-seeking remains to be determined. The present study therefore investigated the contribution to CS-maintained cocaine-seeking under a second-order schedule of reinforcement of the VTA, and its terminal regions, the nucleus accumbens (NAcc) core and basolateral amygdala (BLA), previously shown to be critical for the acquisition of this behaviour. Inactivation of the VTA or NAcc core by direct infusion of a mixture of the GABA(A) and GABA(B) receptor agonists, baclofen and muscimol, decreased cocaine-seeking when rats were drug-free, while drug-seeking after self-administered cocaine was increased only when they were infused into the NAcc core. Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers

Authors+Show Affiliations

Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK. pd241@cus.cam.ac.ukNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15066162

Citation

Di Ciano, Patricia, and Barry J. Everitt. "Contribution of the Ventral Tegmental Area to Cocaine-seeking Maintained By a Drug-paired Conditioned Stimulus in Rats." The European Journal of Neuroscience, vol. 19, no. 6, 2004, pp. 1661-7.
Di Ciano P, Everitt BJ. Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats. Eur J Neurosci. 2004;19(6):1661-7.
Di Ciano, P., & Everitt, B. J. (2004). Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats. The European Journal of Neuroscience, 19(6), 1661-7.
Di Ciano P, Everitt BJ. Contribution of the Ventral Tegmental Area to Cocaine-seeking Maintained By a Drug-paired Conditioned Stimulus in Rats. Eur J Neurosci. 2004;19(6):1661-7. PubMed PMID: 15066162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats. AU - Di Ciano,Patricia, AU - Everitt,Barry J, PY - 2004/4/7/pubmed PY - 2004/5/29/medline PY - 2004/4/7/entrez SP - 1661 EP - 7 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 19 IS - 6 N2 - Stimuli paired with cocaine can maintain cocaine-seeking as conditioned reinforcers. Although converging evidence implicates a role for the ventral tegmental area (VTA) in the primary reinforcing effects of drugs of abuse, the role of the VTA in mediating associative influences over drug-seeking remains to be determined. The present study therefore investigated the contribution to CS-maintained cocaine-seeking under a second-order schedule of reinforcement of the VTA, and its terminal regions, the nucleus accumbens (NAcc) core and basolateral amygdala (BLA), previously shown to be critical for the acquisition of this behaviour. Inactivation of the VTA or NAcc core by direct infusion of a mixture of the GABA(A) and GABA(B) receptor agonists, baclofen and muscimol, decreased cocaine-seeking when rats were drug-free, while drug-seeking after self-administered cocaine was increased only when they were infused into the NAcc core. Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/15066162/Contribution_of_the_ventral_tegmental_area_to_cocaine_seeking_maintained_by_a_drug_paired_conditioned_stimulus_in_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2004&volume=19&issue=6&spage=1661 DB - PRIME DP - Unbound Medicine ER -