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Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women.
Acta Pharmacol Sin. 2004 Apr; 25(4):462-8.AP

Abstract

AIM

To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-alpha (ER-alpha) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women.

METHODS

The VDR Apa I genotype and ER-alpha Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm(2)), BMC (g), and bone areal size (BAS, cm(2)) at lumbar spine 1-4 (L(1-4)) and proximal femur (femoral neck, trochanter and Ward's triangle) were measured by duel-energy X-ray absorptionmetry.

RESULTS

All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After phenotypes were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L(1-4) and Ward's triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur. ER-a Pvu II, Xba I genotype was not related to BMC, BMD, and BAS at all sites.

CONCLUSION

The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.

Authors+Show Affiliations

Center for Preventing and Treating Osteoporosis, Osteoporosis Research Unit, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai 200233, China. yuejuanQ@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15066214

Citation

Qin, Yue-juan, et al. "Association of Vitamin D Receptor and Estrogen Receptor-alpha Gene Polymorphism With Peak Bone Mass and Bone Size in Chinese Women." Acta Pharmacologica Sinica, vol. 25, no. 4, 2004, pp. 462-8.
Qin YJ, Zhang ZL, Huang QR, et al. Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women. Acta Pharmacol Sin. 2004;25(4):462-8.
Qin, Y. J., Zhang, Z. L., Huang, Q. R., He, J. M., Hu, Y. Q., Zhao, Q., Lu, J. H., Li, M., & Liu, Y. J. (2004). Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women. Acta Pharmacologica Sinica, 25(4), 462-8.
Qin YJ, et al. Association of Vitamin D Receptor and Estrogen Receptor-alpha Gene Polymorphism With Peak Bone Mass and Bone Size in Chinese Women. Acta Pharmacol Sin. 2004;25(4):462-8. PubMed PMID: 15066214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women. AU - Qin,Yue-juan, AU - Zhang,Zhen-lin, AU - Huang,Qi-ren, AU - He,Jin-mei, AU - Hu,Yun-qiu, AU - Zhao,Qi, AU - Lu,Jing-hui, AU - Li,Miao, AU - Liu,Yu-juan, PY - 2004/4/7/pubmed PY - 2004/8/11/medline PY - 2004/4/7/entrez SP - 462 EP - 8 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 25 IS - 4 N2 - AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-alpha (ER-alpha) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-alpha Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm(2)), BMC (g), and bone areal size (BAS, cm(2)) at lumbar spine 1-4 (L(1-4)) and proximal femur (femoral neck, trochanter and Ward's triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After phenotypes were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L(1-4) and Ward's triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur. ER-a Pvu II, Xba I genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/15066214/Association_of_vitamin_D_receptor_and_estrogen_receptor_alpha_gene_polymorphism_with_peak_bone_mass_and_bone_size_in_Chinese_women_ L2 - http://www.chinaphar.com/1671-4083/25/462.pdf DB - PRIME DP - Unbound Medicine ER -