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Alcohol, wine, and risk of epithelial ovarian cancer.
Cancer Epidemiol Biomarkers Prev. 2004 Apr; 13(4):592-9.CE

Abstract

Moderate alcohol intake can influence sex hormone levels and affect ovarian function as well as increasing breast cancer risk. This suggests that alcohol might also influence ovarian cancer risk. We have evaluated this among 696 Australian women with histologically confirmed epithelial ovarian cancer and 786 cancer-free control women, selected at random from the electoral roll. Sociodemographic information and a detailed reproductive history were collected in a face-to-face interview, and information about diet and alcohol consumption was obtained from a food frequency questionnaire. Logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Overall, 59% of women drank <1 standard drink/week and only 5% of cases and 8% of controls drank an average of > or =2 standard drinks/day. Compared with nondrinkers, the OR for women who drank an average of > or =2 standard drinks/day was 0.49 (95% CI = 0.30-0.81). This effect did not vary for the different subtypes but was restricted to wine (OR = 0.56, 95% CI = 0.33-0.93 for > or =1 glass/day versus nondrinkers) with no effect for beer (OR = 1.26, 95% CI = 0.65-2.46) or sherry/spirits (OR = 1.07, 95% CI = 0.59-1.95). Combining our results with the six previous population-based studies gave a pooled OR of 0.72 (95% CI = 0.54-0.97) for the highest alcohol intake group versus nondrinkers. These data suggest that alcohol does not increase risk of ovarian cancer. In this Australian population, the inverse association with alcohol was due solely to wine consumption and so may be a consequence of antioxidants and/or phytoestrogens in wine rather than the alcohol itself.

Authors+Show Affiliations

Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. pennyW@qimr.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15066924

Citation

Webb, Penelope M., et al. "Alcohol, Wine, and Risk of Epithelial Ovarian Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 4, 2004, pp. 592-9.
Webb PM, Purdie DM, Bain CJ, et al. Alcohol, wine, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2004;13(4):592-9.
Webb, P. M., Purdie, D. M., Bain, C. J., & Green, A. C. (2004). Alcohol, wine, and risk of epithelial ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(4), 592-9.
Webb PM, et al. Alcohol, Wine, and Risk of Epithelial Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. 2004;13(4):592-9. PubMed PMID: 15066924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol, wine, and risk of epithelial ovarian cancer. AU - Webb,Penelope M, AU - Purdie,David M, AU - Bain,Christopher J, AU - Green,Adèle C, PY - 2004/4/7/pubmed PY - 2005/2/16/medline PY - 2004/4/7/entrez SP - 592 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 4 N2 - Moderate alcohol intake can influence sex hormone levels and affect ovarian function as well as increasing breast cancer risk. This suggests that alcohol might also influence ovarian cancer risk. We have evaluated this among 696 Australian women with histologically confirmed epithelial ovarian cancer and 786 cancer-free control women, selected at random from the electoral roll. Sociodemographic information and a detailed reproductive history were collected in a face-to-face interview, and information about diet and alcohol consumption was obtained from a food frequency questionnaire. Logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Overall, 59% of women drank <1 standard drink/week and only 5% of cases and 8% of controls drank an average of > or =2 standard drinks/day. Compared with nondrinkers, the OR for women who drank an average of > or =2 standard drinks/day was 0.49 (95% CI = 0.30-0.81). This effect did not vary for the different subtypes but was restricted to wine (OR = 0.56, 95% CI = 0.33-0.93 for > or =1 glass/day versus nondrinkers) with no effect for beer (OR = 1.26, 95% CI = 0.65-2.46) or sherry/spirits (OR = 1.07, 95% CI = 0.59-1.95). Combining our results with the six previous population-based studies gave a pooled OR of 0.72 (95% CI = 0.54-0.97) for the highest alcohol intake group versus nondrinkers. These data suggest that alcohol does not increase risk of ovarian cancer. In this Australian population, the inverse association with alcohol was due solely to wine consumption and so may be a consequence of antioxidants and/or phytoestrogens in wine rather than the alcohol itself. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15066924/Alcohol_wine_and_risk_of_epithelial_ovarian_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15066924 DB - PRIME DP - Unbound Medicine ER -