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Improved stent characteristics for prophylaxis of post-ERCP pancreatitis.
Clin Gastroenterol Hepatol 2004; 2(4):322-9CG

Abstract

BACKGROUND & AIMS

Pancreatic stenting is an effective method to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in high-risk patients. This retrospective study evaluated the impact of modified stent characteristics on the rate of post-ERCP pancreatitis, spontaneous stent dislodgment, and stent-related sequelae.

METHODS

A total of 2283 patients underwent 2447 ERCPs over a 6-year period with placement of 3-4F diameter, unflanged pancreatic stents. The indication for stenting was pancreatitis prophylaxis predominantly in suspected sphincter of Oddi dysfunction (SOD), pancreas divisum therapy, and precut sphincterotomy. An abdominal radiograph was obtained 10-14 days later to assess spontaneous stent passage. Post-ERCP pancreatitis was defined according to established criteria. A total of 479 patients underwent repeat ERCPs after an initial ERCP with pancreatic stent placement. The prestenting pancreatogram was then compared with follow-up studies.

RESULTS

The pancreatitis rate with 3F, 4F, 5F, and 6F stents was 7.5%, 10.6%, 9.8%, and 14.6%, respectively (3F vs. 4F, 5F, 6F: P = 0.047). Spontaneous stent dislodgment was 86%, 73%, 67%, and 65%, respectively (3F vs. 4F, 5F, 6F: P < 0.0001). The frequency of ductal changes was 24% in patients with 3-4F stents compared with 80% with 5-6F stents. Ductal perforation from the stents occurred in 3 patients (0.1%).

CONCLUSIONS

Small diameter (3-4F), unflanged pancreatic stents are more effective than the traditionally used stents (5-6F) in preventing post-ERCP pancreatitis. Stent-induced ductal changes and the need for endoscopic removal are also significantly less with 3-4F stents. The 3F stent appears to be superior in all aspects studied. Additional studies are needed to define the ideal method to eliminate post-ERCP pancreatitis.

Authors+Show Affiliations

Division of Gastroenterology/Hepatology, Indiana University Medical Center, Indianapolis, 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15067627

Citation

Rashdan, Abdullah, et al. "Improved Stent Characteristics for Prophylaxis of post-ERCP Pancreatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 2, no. 4, 2004, pp. 322-9.
Rashdan A, Fogel EL, McHenry L, et al. Improved stent characteristics for prophylaxis of post-ERCP pancreatitis. Clin Gastroenterol Hepatol. 2004;2(4):322-9.
Rashdan, A., Fogel, E. L., McHenry, L., Sherman, S., Temkit, M., & Lehman, G. A. (2004). Improved stent characteristics for prophylaxis of post-ERCP pancreatitis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 2(4), pp. 322-9.
Rashdan A, et al. Improved Stent Characteristics for Prophylaxis of post-ERCP Pancreatitis. Clin Gastroenterol Hepatol. 2004;2(4):322-9. PubMed PMID: 15067627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved stent characteristics for prophylaxis of post-ERCP pancreatitis. AU - Rashdan,Abdullah, AU - Fogel,Evan L, AU - McHenry,Lee,Jr AU - Sherman,Stuart, AU - Temkit,M'Hamed, AU - Lehman,Glen A, PY - 2004/4/7/pubmed PY - 2004/8/17/medline PY - 2004/4/7/entrez SP - 322 EP - 9 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 2 IS - 4 N2 - BACKGROUND & AIMS: Pancreatic stenting is an effective method to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in high-risk patients. This retrospective study evaluated the impact of modified stent characteristics on the rate of post-ERCP pancreatitis, spontaneous stent dislodgment, and stent-related sequelae. METHODS: A total of 2283 patients underwent 2447 ERCPs over a 6-year period with placement of 3-4F diameter, unflanged pancreatic stents. The indication for stenting was pancreatitis prophylaxis predominantly in suspected sphincter of Oddi dysfunction (SOD), pancreas divisum therapy, and precut sphincterotomy. An abdominal radiograph was obtained 10-14 days later to assess spontaneous stent passage. Post-ERCP pancreatitis was defined according to established criteria. A total of 479 patients underwent repeat ERCPs after an initial ERCP with pancreatic stent placement. The prestenting pancreatogram was then compared with follow-up studies. RESULTS: The pancreatitis rate with 3F, 4F, 5F, and 6F stents was 7.5%, 10.6%, 9.8%, and 14.6%, respectively (3F vs. 4F, 5F, 6F: P = 0.047). Spontaneous stent dislodgment was 86%, 73%, 67%, and 65%, respectively (3F vs. 4F, 5F, 6F: P < 0.0001). The frequency of ductal changes was 24% in patients with 3-4F stents compared with 80% with 5-6F stents. Ductal perforation from the stents occurred in 3 patients (0.1%). CONCLUSIONS: Small diameter (3-4F), unflanged pancreatic stents are more effective than the traditionally used stents (5-6F) in preventing post-ERCP pancreatitis. Stent-induced ductal changes and the need for endoscopic removal are also significantly less with 3-4F stents. The 3F stent appears to be superior in all aspects studied. Additional studies are needed to define the ideal method to eliminate post-ERCP pancreatitis. SN - 1542-3565 UR - https://www.unboundmedicine.com/medline/citation/15067627/Improved_stent_characteristics_for_prophylaxis_of_post_ERCP_pancreatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S154235650400062X DB - PRIME DP - Unbound Medicine ER -