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Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women.
J Bone Miner Res. 2004 May; 19(5):737-44.JB

Abstract

To study effects of statins on human bone, 82 postmenopausal women were randomized to 1-year treatment with simvastatin 40 mg/day or placebo. The study showed no effect of simvastatin on biochemical bone markers or on BMD at the hip or spine. Thus, our results do not support a general beneficial effect of simvastatin on bone.

INTRODUCTION

Statins have been reported to cause bone anabolic as well as antiresorptive effects, and therefore statins have been suggested as potential agents in treatment of osteoporosis.

MATERIALS AND METHODS

In a double-blinded design, 82 healthy postmenopausal women with osteopenia were randomized to 1-year simvastatin treatment 40 mg/day or placebo. BMD and plasma levels of cholesterol, parathyroid hormone (PTH), and biochemical bone markers were measured at baseline, after 1 year of treatment (week 52), and 26 weeks after withdrawal of treatment (week 78). Calcium supplements (400 mg/day) were administrated during the entire 1.5-year study period.

RESULTS

Seventy-eight women completed the 1-year treatment. After 1 year, simvastatin but not placebo caused reduced plasma cholesterol (-27% versus +1%, p < 0.001) and low-density lipoprotein (LDL) levels (-43% versus +1%, p < 0.001). After withdrawal of treatment, cholesterol and LDL levels returned to baseline levels and no longer differed from the placebo group. However, plasma levels of PTH and biochemical bone markers did not differ between groups at week 52 or 78. Compared with placebo, simvastatin caused no changes in BMD at the lumbar spine, total hip, femoral neck, or whole body at week 52 or 78. However, a significant increase in BMD was found in response to simvastatin at the forearm. Within the simvastatin group, changes in cholesterol levels did not correlate to BMD changes at any site.

CONCLUSIONS

Our results do not support a general beneficial effect of simvastatin on bone.

Authors+Show Affiliations

Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark. rejnmark@post6.tele.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15068496

Citation

Rejnmark, Lars, et al. "Effects of Simvastatin On Bone Turnover and BMD: a 1-year Randomized Controlled Trial in Postmenopausal Osteopenic Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 19, no. 5, 2004, pp. 737-44.
Rejnmark L, Buus NH, Vestergaard P, et al. Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. J Bone Miner Res. 2004;19(5):737-44.
Rejnmark, L., Buus, N. H., Vestergaard, P., Heickendorff, L., Andreasen, F., Larsen, M. L., & Mosekilde, L. (2004). Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 19(5), 737-44.
Rejnmark L, et al. Effects of Simvastatin On Bone Turnover and BMD: a 1-year Randomized Controlled Trial in Postmenopausal Osteopenic Women. J Bone Miner Res. 2004;19(5):737-44. PubMed PMID: 15068496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. AU - Rejnmark,Lars, AU - Buus,Niels Henrik, AU - Vestergaard,Peter, AU - Heickendorff,Lene, AU - Andreasen,Frederik, AU - Larsen,Mogens Lytken, AU - Mosekilde,Leif, Y1 - 2004/02/16/ PY - 2003/09/06/received PY - 2003/12/11/revised PY - 2004/01/09/accepted PY - 2004/4/8/pubmed PY - 2004/8/4/medline PY - 2004/4/8/entrez SP - 737 EP - 44 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 19 IS - 5 N2 - UNLABELLED: To study effects of statins on human bone, 82 postmenopausal women were randomized to 1-year treatment with simvastatin 40 mg/day or placebo. The study showed no effect of simvastatin on biochemical bone markers or on BMD at the hip or spine. Thus, our results do not support a general beneficial effect of simvastatin on bone. INTRODUCTION: Statins have been reported to cause bone anabolic as well as antiresorptive effects, and therefore statins have been suggested as potential agents in treatment of osteoporosis. MATERIALS AND METHODS: In a double-blinded design, 82 healthy postmenopausal women with osteopenia were randomized to 1-year simvastatin treatment 40 mg/day or placebo. BMD and plasma levels of cholesterol, parathyroid hormone (PTH), and biochemical bone markers were measured at baseline, after 1 year of treatment (week 52), and 26 weeks after withdrawal of treatment (week 78). Calcium supplements (400 mg/day) were administrated during the entire 1.5-year study period. RESULTS: Seventy-eight women completed the 1-year treatment. After 1 year, simvastatin but not placebo caused reduced plasma cholesterol (-27% versus +1%, p < 0.001) and low-density lipoprotein (LDL) levels (-43% versus +1%, p < 0.001). After withdrawal of treatment, cholesterol and LDL levels returned to baseline levels and no longer differed from the placebo group. However, plasma levels of PTH and biochemical bone markers did not differ between groups at week 52 or 78. Compared with placebo, simvastatin caused no changes in BMD at the lumbar spine, total hip, femoral neck, or whole body at week 52 or 78. However, a significant increase in BMD was found in response to simvastatin at the forearm. Within the simvastatin group, changes in cholesterol levels did not correlate to BMD changes at any site. CONCLUSIONS: Our results do not support a general beneficial effect of simvastatin on bone. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/15068496/Effects_of_simvastatin_on_bone_turnover_and_BMD:_a_1_year_randomized_controlled_trial_in_postmenopausal_osteopenic_women_ L2 - https://doi.org/10.1359/JBMR.040209 DB - PRIME DP - Unbound Medicine ER -