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Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone.
J Pediatr. 2004 Apr; 144(4):437-43.JPed

Abstract

OBJECTIVES

To investigate the effects of growth hormone (GH) therapy on craniofacial growth and body proportions in growth hormone deficient children.

STUDY DESIGN

By using a cross-sectional study design, we investigated GH effects on craniofacial growth with photographic facial morphometrics, head circumference, and hand and foot size in 52 children with GH deficiency (GHD) treated with GH (0.27 mg/kg/wk) for 0.19 to 15.5 years, compared with untreated children with GHD and normal first-degree relatives. To detect disproportion and to correct for stature, age and height age (HA) SD scores were analyzed.

RESULTS

Untreated subjects with GHD had retarded facial height and width (P values=.001) compared with normal controls; small head circumference for age and HA (P=.001); small hands for age (P<.001) that were large for HA (P=.003); and small feet for age (P<.001) that were normal for HA. When compared with normal controls, GH-treated subjects had proportional facial heights but narrower facial widths. Head circumference, however, increased disproportionately to height (P=.001), becoming large for stature, and increasing with duration of therapy and cumulative GH dose (P<.001). Hands and feet grew proportionately to height.

CONCLUSION

Growth hormone treatment with conventional doses partially corrects craniofacial deficits and does not adversely affect hand and foot growth but appears to result in excessive head circumference growth.

Authors+Show Affiliations

Pediatric Endocrinology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15069389

Citation

Segal, David G., et al. "Craniofacial and Acral Growth Responses in Growth Hormone-deficient Children Treated With Growth Hormone." The Journal of Pediatrics, vol. 144, no. 4, 2004, pp. 437-43.
Segal DG, Pescovitz OH, Schaefer GB, et al. Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone. J Pediatr. 2004;144(4):437-43.
Segal, D. G., Pescovitz, O. H., Schaefer, G. B., & DiMeglio, L. A. (2004). Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone. The Journal of Pediatrics, 144(4), 437-43.
Segal DG, et al. Craniofacial and Acral Growth Responses in Growth Hormone-deficient Children Treated With Growth Hormone. J Pediatr. 2004;144(4):437-43. PubMed PMID: 15069389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone. AU - Segal,David G, AU - Pescovitz,Ora Hirsch, AU - Schaefer,G Bradley, AU - DiMeglio,Linda A, PY - 2004/4/8/pubmed PY - 2004/6/2/medline PY - 2004/4/8/entrez SP - 437 EP - 43 JF - The Journal of pediatrics JO - J Pediatr VL - 144 IS - 4 N2 - OBJECTIVES: To investigate the effects of growth hormone (GH) therapy on craniofacial growth and body proportions in growth hormone deficient children. STUDY DESIGN: By using a cross-sectional study design, we investigated GH effects on craniofacial growth with photographic facial morphometrics, head circumference, and hand and foot size in 52 children with GH deficiency (GHD) treated with GH (0.27 mg/kg/wk) for 0.19 to 15.5 years, compared with untreated children with GHD and normal first-degree relatives. To detect disproportion and to correct for stature, age and height age (HA) SD scores were analyzed. RESULTS: Untreated subjects with GHD had retarded facial height and width (P values=.001) compared with normal controls; small head circumference for age and HA (P=.001); small hands for age (P<.001) that were large for HA (P=.003); and small feet for age (P<.001) that were normal for HA. When compared with normal controls, GH-treated subjects had proportional facial heights but narrower facial widths. Head circumference, however, increased disproportionately to height (P=.001), becoming large for stature, and increasing with duration of therapy and cumulative GH dose (P<.001). Hands and feet grew proportionately to height. CONCLUSION: Growth hormone treatment with conventional doses partially corrects craniofacial deficits and does not adversely affect hand and foot growth but appears to result in excessive head circumference growth. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/15069389/Craniofacial_and_acral_growth_responses_in_growth_hormone_deficient_children_treated_with_growth_hormone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(04)00020-4 DB - PRIME DP - Unbound Medicine ER -