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Plant sterols: factors affecting their efficacy and safety as functional food ingredients.

Abstract

Plant sterols are naturally occurring molecules that humanity has evolved with. Herein, we have critically evaluated recent literature pertaining to the myriad of factors affecting efficacy and safety of plant sterols in free and esterified forms. We conclude that properly solubilized 4-desmetyl plant sterols, in ester or free form, in reasonable doses (0.8-1.0 g of equivalents per day) and in various vehicles including natural sources, and as part of a healthy diet and lifestyle, are important dietary components for lowering low density lipoprotein (LDL) cholesterol and maintaining good heart health. In addition to their cholesterol lowering properties, plant sterols possess anti-cancer, anti-inflammatory, anti-atherogenicity, and anti-oxidation activities, and should thus be of clinical importance, even for those individuals without elevated LDL cholesterol. The carotenoid lowering effect of plant sterols should be corrected by increasing intake of food that is rich in carotenoids. In pregnant and lactating women and children, further study is needed to verify the dose required to decrease blood cholesterol without affecting fat-soluble vitamins and carotenoid status.

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  • Authors+Show Affiliations

    ,

    Biochemical Profiling, Paradigm Genetics, P.O. Box 14528, Research Triangle Park, North Carolina 27709-4528, USA. aberger@paragen.com

    ,

    Source

    Lipids in health and disease 3: 2004 Apr 07 pg 5

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15070410

    Citation

    Berger, Alvin, et al. "Plant Sterols: Factors Affecting Their Efficacy and Safety as Functional Food Ingredients." Lipids in Health and Disease, vol. 3, 2004, p. 5.
    Berger A, Jones PJ, Abumweis SS. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis. 2004;3:5.
    Berger, A., Jones, P. J., & Abumweis, S. S. (2004). Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids in Health and Disease, 3, p. 5.
    Berger A, Jones PJ, Abumweis SS. Plant Sterols: Factors Affecting Their Efficacy and Safety as Functional Food Ingredients. Lipids Health Dis. 2004 Apr 7;3:5. PubMed PMID: 15070410.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plant sterols: factors affecting their efficacy and safety as functional food ingredients. AU - Berger,Alvin, AU - Jones,Peter J H, AU - Abumweis,Suhad S, Y1 - 2004/04/07/ PY - 2004/02/13/received PY - 2004/04/07/accepted PY - 2004/4/9/pubmed PY - 2004/4/9/medline PY - 2004/4/9/entrez SP - 5 EP - 5 JF - Lipids in health and disease JO - Lipids Health Dis VL - 3 N2 - Plant sterols are naturally occurring molecules that humanity has evolved with. Herein, we have critically evaluated recent literature pertaining to the myriad of factors affecting efficacy and safety of plant sterols in free and esterified forms. We conclude that properly solubilized 4-desmetyl plant sterols, in ester or free form, in reasonable doses (0.8-1.0 g of equivalents per day) and in various vehicles including natural sources, and as part of a healthy diet and lifestyle, are important dietary components for lowering low density lipoprotein (LDL) cholesterol and maintaining good heart health. In addition to their cholesterol lowering properties, plant sterols possess anti-cancer, anti-inflammatory, anti-atherogenicity, and anti-oxidation activities, and should thus be of clinical importance, even for those individuals without elevated LDL cholesterol. The carotenoid lowering effect of plant sterols should be corrected by increasing intake of food that is rich in carotenoids. In pregnant and lactating women and children, further study is needed to verify the dose required to decrease blood cholesterol without affecting fat-soluble vitamins and carotenoid status. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/15070410/full_citation L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-3-5 DB - PRIME DP - Unbound Medicine ER -