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Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding.
J Clin Endocrinol Metab. 2004 Apr; 89(4):1662-5.JC

Abstract

Ghrelin, a natural GH secretagogue, is predominantly produced by the stomach. Ghrelin has other actions including orexant activity, modulation of energy balance, and modulation of endocrine and nonendocrine functions. Ghrelin secretion is increased by fasting and energy restriction but decreased by food intake, glucose, insulin, and somatostatin. Ghrelin secretion does not seem to be a function of age; in fact, morning ghrelin levels after overnight fasting in prepubertal and pubertal children are similar to those in young adults. To clarify whether children and adults have the same sensitivity to the inhibitory effect of food intake, we studied the ghrelin response to a standardized light breakfast (SLB) in 10 prepubertal lean children whose results were compared with those recorded in 19 normal-weight adults. Basal ghrelin levels in children (median, 224.5; 25th to 75th percentile, 122.0-447.7 pg/ml) and adults (338.0; 238.0-512.0 pg/ml) were similar. SLB inhibited ghrelin levels in adults (263.0; 190.0-399.0 pg/ml). However, no change in ghrelin levels after SLB (206.5; 105.0-274.0 pg/ml) was recorded in children. Thus, food intake inhibits ghrelin secretion in adults but not in children. Ghrelin refractoriness to inhibition by food intake in children would reflect a peculiar functional profile of the ghrelin system in childhood.

Authors+Show Affiliations

Units of Pediatrics, Department of Medical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15070928

Citation

Bellone, Simonetta, et al. "Ghrelin Secretion in Childhood Is Refractory to the Inhibitory Effect of Feeding." The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 4, 2004, pp. 1662-5.
Bellone S, Castellino N, Broglio F, et al. Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. J Clin Endocrinol Metab. 2004;89(4):1662-5.
Bellone, S., Castellino, N., Broglio, F., Rapa, A., Vivenza, D., Radetti, G., Bellone, J., Gottero, C., Ghigo, E., & Bona, G. (2004). Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. The Journal of Clinical Endocrinology and Metabolism, 89(4), 1662-5.
Bellone S, et al. Ghrelin Secretion in Childhood Is Refractory to the Inhibitory Effect of Feeding. J Clin Endocrinol Metab. 2004;89(4):1662-5. PubMed PMID: 15070928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. AU - Bellone,Simonetta, AU - Castellino,Nadia, AU - Broglio,Fabio, AU - Rapa,Anna, AU - Vivenza,Daniela, AU - Radetti,Giorgio, AU - Bellone,Jaele, AU - Gottero,Cristina, AU - Ghigo,Ezio, AU - Bona,Gianni, PY - 2004/4/9/pubmed PY - 2004/5/12/medline PY - 2004/4/9/entrez SP - 1662 EP - 5 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 89 IS - 4 N2 - Ghrelin, a natural GH secretagogue, is predominantly produced by the stomach. Ghrelin has other actions including orexant activity, modulation of energy balance, and modulation of endocrine and nonendocrine functions. Ghrelin secretion is increased by fasting and energy restriction but decreased by food intake, glucose, insulin, and somatostatin. Ghrelin secretion does not seem to be a function of age; in fact, morning ghrelin levels after overnight fasting in prepubertal and pubertal children are similar to those in young adults. To clarify whether children and adults have the same sensitivity to the inhibitory effect of food intake, we studied the ghrelin response to a standardized light breakfast (SLB) in 10 prepubertal lean children whose results were compared with those recorded in 19 normal-weight adults. Basal ghrelin levels in children (median, 224.5; 25th to 75th percentile, 122.0-447.7 pg/ml) and adults (338.0; 238.0-512.0 pg/ml) were similar. SLB inhibited ghrelin levels in adults (263.0; 190.0-399.0 pg/ml). However, no change in ghrelin levels after SLB (206.5; 105.0-274.0 pg/ml) was recorded in children. Thus, food intake inhibits ghrelin secretion in adults but not in children. Ghrelin refractoriness to inhibition by food intake in children would reflect a peculiar functional profile of the ghrelin system in childhood. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15070928/Ghrelin_secretion_in_childhood_is_refractory_to_the_inhibitory_effect_of_feeding_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2003-031207 DB - PRIME DP - Unbound Medicine ER -