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Impaired judgments of sadness but not happiness following bilateral amygdala damage.
J Cogn Neurosci. 2004 Apr; 16(3):453-62.JC

Abstract

Although the amygdala's role in processing facial expressions of fear has been well established, its role in the processing of other emotions is unclear. In particular, evidence for the amygdala's involvement in processing expressions of happiness and sadness remains controversial. To clarify this issue, we constructed a series of morphed stimuli whose emotional expression varied gradually from very faint to more pronounced. Five morphs each of sadness and happiness, as well as neutral faces, were shown to 27 subjects with unilateral amygdala damage and 5 with complete bilateral amygdala damage, whose data were compared to those from 12 brain damaged and 26 normal controls. Subjects were asked to rate the intensity and to label the stimuli. Subjects with unilateral amygdala damage performed very comparably to controls. By contrast, subjects with bilateral amygdala damage showed a specific impairment in rating sad faces, but performed normally in rating happy faces. Furthermore, subjects with right unilateral amygdala damage performed somewhat worse than subjects with left unilateral amygdala damage. The findings suggest that the amygdala's role in processing of emotional facial expressions encompasses multiple negatively valenced emotions, including fear and sadness.

Authors+Show Affiliations

University of Iowa, Iowa, USA. radolphs@hss.caltech.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15072680

Citation

Adolphs, Ralph, and Daniel Tranel. "Impaired Judgments of Sadness but Not Happiness Following Bilateral Amygdala Damage." Journal of Cognitive Neuroscience, vol. 16, no. 3, 2004, pp. 453-62.
Adolphs R, Tranel D. Impaired judgments of sadness but not happiness following bilateral amygdala damage. J Cogn Neurosci. 2004;16(3):453-62.
Adolphs, R., & Tranel, D. (2004). Impaired judgments of sadness but not happiness following bilateral amygdala damage. Journal of Cognitive Neuroscience, 16(3), 453-62.
Adolphs R, Tranel D. Impaired Judgments of Sadness but Not Happiness Following Bilateral Amygdala Damage. J Cogn Neurosci. 2004;16(3):453-62. PubMed PMID: 15072680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired judgments of sadness but not happiness following bilateral amygdala damage. AU - Adolphs,Ralph, AU - Tranel,Daniel, PY - 2004/4/10/pubmed PY - 2004/5/18/medline PY - 2004/4/10/entrez SP - 453 EP - 62 JF - Journal of cognitive neuroscience JO - J Cogn Neurosci VL - 16 IS - 3 N2 - Although the amygdala's role in processing facial expressions of fear has been well established, its role in the processing of other emotions is unclear. In particular, evidence for the amygdala's involvement in processing expressions of happiness and sadness remains controversial. To clarify this issue, we constructed a series of morphed stimuli whose emotional expression varied gradually from very faint to more pronounced. Five morphs each of sadness and happiness, as well as neutral faces, were shown to 27 subjects with unilateral amygdala damage and 5 with complete bilateral amygdala damage, whose data were compared to those from 12 brain damaged and 26 normal controls. Subjects were asked to rate the intensity and to label the stimuli. Subjects with unilateral amygdala damage performed very comparably to controls. By contrast, subjects with bilateral amygdala damage showed a specific impairment in rating sad faces, but performed normally in rating happy faces. Furthermore, subjects with right unilateral amygdala damage performed somewhat worse than subjects with left unilateral amygdala damage. The findings suggest that the amygdala's role in processing of emotional facial expressions encompasses multiple negatively valenced emotions, including fear and sadness. SN - 0898-929X UR - https://www.unboundmedicine.com/medline/citation/15072680/Impaired_judgments_of_sadness_but_not_happiness_following_bilateral_amygdala_damage_ L2 - https://www.mitpressjournals.org/doi/10.1162/089892904322926782?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -