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Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialyzed children.
Turk J Pediatr. 2004 Jan-Mar; 46(1):28-31.TJ

Abstract

In this study we investigated the value of biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialysis patients. The study was carried out in 22 chronic renal failure patients (mean age: 16.1 +/- 4.5) being treated with chronic dialysis. There were three groups according to intact parathormone (iPTH) levels: Group I (n: 6): iPTH levels were less than 200 pg/ml; Group II (n: 9): iPTH levels were between 201 and 500 pg/ml; and Group III (n: 7). iPTH levels were higher than 501 pg/ml. We investigated iPTH, bone alkaline phosphatase, total serum alkaline phosphatase, osteocalcin, serum type 1 procollagen peptide (PICP) and insulin-like growth factor-1 (IGF-1) levels in all patients. In group III mean bone alkaline phosphatase level (126.0 +/- 10.95) was significantly higher than in both group I and group II (52.16 +/- 22.8, 57.35 +/- 16.21) (p < 0.001). Mean osteocalcin level (35.13 +/- 2.93) in group I was significantly lower than in group III (40.52 +/- 2.83) (p < 0.05). Serum alkaline phosphatase, PICP and IGF-1 levels were not different between the groups (p > 0.05). There was a significant positive correlation between bone alkaline phosphatase and iPTH (r = 0.80, p < 0.0001). Serum osteocalcin correlated with both bone alkaline phosphatase and iPTH (correlation) coefficients were r = 0.44 and r = 0.51 respectively, p < 0.05). It is concluded that bone alkaline phosphatase and osteoocalcin combined with iPTH level seem to be useful noninvasive markers of bone metabolism in dialysis patients.

Authors+Show Affiliations

Department of Pediatric Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15074371

Citation

Baskin, Esra, et al. "Biochemical Markers of Bone Turnover in the Diagnosis of Renal Osteodystrophy in Dialyzed Children." The Turkish Journal of Pediatrics, vol. 46, no. 1, 2004, pp. 28-31.
Baskin E, Beşbaş N, Saatçi U, et al. Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialyzed children. Turk J Pediatr. 2004;46(1):28-31.
Baskin, E., Beşbaş, N., Saatçi, U., Hasçelik, G., Topaloğlu, R., Ozen, S., & Bakkaloğlu, A. (2004). Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialyzed children. The Turkish Journal of Pediatrics, 46(1), 28-31.
Baskin E, et al. Biochemical Markers of Bone Turnover in the Diagnosis of Renal Osteodystrophy in Dialyzed Children. Turk J Pediatr. 2004 Jan-Mar;46(1):28-31. PubMed PMID: 15074371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialyzed children. AU - Baskin,Esra, AU - Beşbaş,Nesrin, AU - Saatçi,Umit, AU - Hasçelik,Gülşen, AU - Topaloğlu,Rezan, AU - Ozen,Seza, AU - Bakkaloğlu,Ayşin, PY - 2004/4/13/pubmed PY - 2004/6/21/medline PY - 2004/4/13/entrez SP - 28 EP - 31 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 46 IS - 1 N2 - In this study we investigated the value of biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialysis patients. The study was carried out in 22 chronic renal failure patients (mean age: 16.1 +/- 4.5) being treated with chronic dialysis. There were three groups according to intact parathormone (iPTH) levels: Group I (n: 6): iPTH levels were less than 200 pg/ml; Group II (n: 9): iPTH levels were between 201 and 500 pg/ml; and Group III (n: 7). iPTH levels were higher than 501 pg/ml. We investigated iPTH, bone alkaline phosphatase, total serum alkaline phosphatase, osteocalcin, serum type 1 procollagen peptide (PICP) and insulin-like growth factor-1 (IGF-1) levels in all patients. In group III mean bone alkaline phosphatase level (126.0 +/- 10.95) was significantly higher than in both group I and group II (52.16 +/- 22.8, 57.35 +/- 16.21) (p < 0.001). Mean osteocalcin level (35.13 +/- 2.93) in group I was significantly lower than in group III (40.52 +/- 2.83) (p < 0.05). Serum alkaline phosphatase, PICP and IGF-1 levels were not different between the groups (p > 0.05). There was a significant positive correlation between bone alkaline phosphatase and iPTH (r = 0.80, p < 0.0001). Serum osteocalcin correlated with both bone alkaline phosphatase and iPTH (correlation) coefficients were r = 0.44 and r = 0.51 respectively, p < 0.05). It is concluded that bone alkaline phosphatase and osteoocalcin combined with iPTH level seem to be useful noninvasive markers of bone metabolism in dialysis patients. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/15074371/Biochemical_markers_of_bone_turnover_in_the_diagnosis_of_renal_osteodystrophy_in_dialyzed_children_ L2 - https://www.diseaseinfosearch.org/result/6208 DB - PRIME DP - Unbound Medicine ER -