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Risperidone-induced retrograde ejaculation: case report and review of the literature.
Int Clin Psychopharmacol. 2004 Mar; 19(2):111-2.IC

Abstract

Medication adherence with antipsychotics is adversely impacted by the burden of untoward adverse effects. In particular, sexual side-effects may interfere with compliance, but are often underreported by patients. Sexual dysfunction related to hyperprolactinemia is commonly described, but ejaculatory disturbance due to potent alpha1 adrenergic antagonism may also occur, and has been reported frequently with certain typical antipsychotics such as thioridazine, but rarely with atypical antipsychotics. Presented here is the case of a 51 year old male with schizophrenia who developed retrograde ejaculation on high dose risperidone therapy (8 mg/day) with prompt resolution of symptoms upon dose reduction. The absence of decreased libido or erectile dysfunction indicates that alpha1 adrenergic antagonism and not low serum testosterone due to hyperprolactinemia is the etiology for this side-effect. This case illustrates another mechanism for sexual adverse effects, and the need for routine inquiry into sexual dysfunction during atypical antipsychotic therapy.

Authors+Show Affiliations

Mental Illness Research Education and Clinical Centers (MIRECC), Veterans Affairs San Diego Healthcare System, San Diego, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15076020

Citation

Loh, Catherine, et al. "Risperidone-induced Retrograde Ejaculation: Case Report and Review of the Literature." International Clinical Psychopharmacology, vol. 19, no. 2, 2004, pp. 111-2.
Loh C, Leckband SG, Meyer JM, et al. Risperidone-induced retrograde ejaculation: case report and review of the literature. Int Clin Psychopharmacol. 2004;19(2):111-2.
Loh, C., Leckband, S. G., Meyer, J. M., & Turner, E. (2004). Risperidone-induced retrograde ejaculation: case report and review of the literature. International Clinical Psychopharmacology, 19(2), 111-2.
Loh C, et al. Risperidone-induced Retrograde Ejaculation: Case Report and Review of the Literature. Int Clin Psychopharmacol. 2004;19(2):111-2. PubMed PMID: 15076020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risperidone-induced retrograde ejaculation: case report and review of the literature. AU - Loh,Catherine, AU - Leckband,Susan G, AU - Meyer,Jonathan M, AU - Turner,Eric, PY - 2004/4/13/pubmed PY - 2004/6/24/medline PY - 2004/4/13/entrez SP - 111 EP - 2 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 19 IS - 2 N2 - Medication adherence with antipsychotics is adversely impacted by the burden of untoward adverse effects. In particular, sexual side-effects may interfere with compliance, but are often underreported by patients. Sexual dysfunction related to hyperprolactinemia is commonly described, but ejaculatory disturbance due to potent alpha1 adrenergic antagonism may also occur, and has been reported frequently with certain typical antipsychotics such as thioridazine, but rarely with atypical antipsychotics. Presented here is the case of a 51 year old male with schizophrenia who developed retrograde ejaculation on high dose risperidone therapy (8 mg/day) with prompt resolution of symptoms upon dose reduction. The absence of decreased libido or erectile dysfunction indicates that alpha1 adrenergic antagonism and not low serum testosterone due to hyperprolactinemia is the etiology for this side-effect. This case illustrates another mechanism for sexual adverse effects, and the need for routine inquiry into sexual dysfunction during atypical antipsychotic therapy. SN - 0268-1315 UR - https://www.unboundmedicine.com/medline/citation/15076020/Risperidone_induced_retrograde_ejaculation:_case_report_and_review_of_the_literature_ L2 - https://doi.org/10.1097/00004850-200403000-00009 DB - PRIME DP - Unbound Medicine ER -