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Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction.
Am Heart J 2004; 147(4):685-9AH

Abstract

BACKGROUND

Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects.

METHODS

This study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly subjects. For 2206 participants, a baseline echocardiogram and blood specimens for APOE typing were available. Cardiac dysfunction was considered present when fractional shortening was <or=25%. Multivariate logistic regression was used to calculate odds ratios (ORs). The epsilon3/epsilon3 genotype served as a reference category.

RESULTS

In participants who were homozygous for the epsilon4 allele, the odds of cardiac dysfunction was increased 3-fold (OR, 3.1; 95% CI, 1.2-8.1), whereas the odds of cardiac dysfunction in persons with APOE epsilon3/epsilon4 was not significantly increased (OR, 1.5; 95% CI, 0.9-2.5). There was a significant allele-effect relationship for the epsilon4 allele (P-trend <.05). These elevated odds remained after adjustment for cholesterol levels and atherosclerosis parameters. Risks associated with APOE epsilon4/epsilon4 and APOE epsilon3/epsilon4 were more pronounced in participants aged >or=65 years.

CONCLUSION

The APOE epsilon4 allele is an independent risk factor for cardiac dysfunction in elderly people. Besides well-known effects on atherosclerosis and cholesterol levels, there may be other mechanisms, such as apoptosis, through which this allele exerts negative effects on myocardial performance.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15077085

Citation

Bleumink, Gysèle S., et al. "Apolipoprotein E Epsilon4 Allele Is Associated With Left Ventricular Systolic Dysfunction." American Heart Journal, vol. 147, no. 4, 2004, pp. 685-9.
Bleumink GS, van Duijn CM, Kingma JH, et al. Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. Am Heart J. 2004;147(4):685-9.
Bleumink, G. S., van Duijn, C. M., Kingma, J. H., Witteman, J. C., Hofman, A., & Stricker, B. H. (2004). Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. American Heart Journal, 147(4), pp. 685-9.
Bleumink GS, et al. Apolipoprotein E Epsilon4 Allele Is Associated With Left Ventricular Systolic Dysfunction. Am Heart J. 2004;147(4):685-9. PubMed PMID: 15077085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. AU - Bleumink,Gysèle S, AU - van Duijn,Cornelia M, AU - Kingma,J Herre, AU - Witteman,Jacqueline C M, AU - Hofman,Albert, AU - Stricker,Bruno H Ch, PY - 2004/4/13/pubmed PY - 2004/8/10/medline PY - 2004/4/13/entrez SP - 685 EP - 9 JF - American heart journal JO - Am. Heart J. VL - 147 IS - 4 N2 - BACKGROUND: Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects. METHODS: This study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly subjects. For 2206 participants, a baseline echocardiogram and blood specimens for APOE typing were available. Cardiac dysfunction was considered present when fractional shortening was <or=25%. Multivariate logistic regression was used to calculate odds ratios (ORs). The epsilon3/epsilon3 genotype served as a reference category. RESULTS: In participants who were homozygous for the epsilon4 allele, the odds of cardiac dysfunction was increased 3-fold (OR, 3.1; 95% CI, 1.2-8.1), whereas the odds of cardiac dysfunction in persons with APOE epsilon3/epsilon4 was not significantly increased (OR, 1.5; 95% CI, 0.9-2.5). There was a significant allele-effect relationship for the epsilon4 allele (P-trend <.05). These elevated odds remained after adjustment for cholesterol levels and atherosclerosis parameters. Risks associated with APOE epsilon4/epsilon4 and APOE epsilon3/epsilon4 were more pronounced in participants aged >or=65 years. CONCLUSION: The APOE epsilon4 allele is an independent risk factor for cardiac dysfunction in elderly people. Besides well-known effects on atherosclerosis and cholesterol levels, there may be other mechanisms, such as apoptosis, through which this allele exerts negative effects on myocardial performance. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/15077085/Apolipoprotein_E_epsilon4_allele_is_associated_with_left_ventricular_systolic_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002870303008354 DB - PRIME DP - Unbound Medicine ER -