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The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition.
Eur J Neurosci. 2004 Apr; 19(7):1699-707.EJ

Abstract

A diet high in saturated fat (HF) decreases levels of brain-derived neurotrophic factor (BDNF), to the extent that compromises neuroplasticity and cognitive function, and aggravates the outcome of brain insult. By using the antioxidant power of vitamin E, we performed studies to determine the role of oxidative stress as a mediator for the effects of BDNF on synaptic plasticity and cognition caused by consumption of the HF diet. Male adult rats were maintained on a HF diet for 2 months with or without 500 IU/kg of vitamin E. Supplementation of the HF diet with vitamin E dramatically reduced oxidative damage, normalized levels of BDNF, synapsin I and cyclic AMP-response element-binding protein (CREB), caused by the consumption of the HF diet. In addition, vitamin E supplementation preserved the process of activation of synapsin I and CREB, and reversed the HF-impaired cognitive function. It is known that BDNF facilitates the synapse by modulating synapsin I and CREB, which have been implicated in synaptic plasticity associated to learning and memory. These results show that oxidative stress can interact with the BDNF system to modulate synaptic plasticity and cognitive function. Therefore, studies appear to reveal a mechanism by which events classically related to the maintenance of energy balance of the cell, such as oxidative stress, can interact with molecular events that modulate neuronal and behavioural plasticity.

Authors+Show Affiliations

Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, California 90095, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15078544

Citation

Wu, Aiguo, et al. "The Interplay Between Oxidative Stress and Brain-derived Neurotrophic Factor Modulates the Outcome of a Saturated Fat Diet On Synaptic Plasticity and Cognition." The European Journal of Neuroscience, vol. 19, no. 7, 2004, pp. 1699-707.
Wu A, Ying Z, Gomez-Pinilla F. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci. 2004;19(7):1699-707.
Wu, A., Ying, Z., & Gomez-Pinilla, F. (2004). The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. The European Journal of Neuroscience, 19(7), 1699-707.
Wu A, Ying Z, Gomez-Pinilla F. The Interplay Between Oxidative Stress and Brain-derived Neurotrophic Factor Modulates the Outcome of a Saturated Fat Diet On Synaptic Plasticity and Cognition. Eur J Neurosci. 2004;19(7):1699-707. PubMed PMID: 15078544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. AU - Wu,Aiguo, AU - Ying,Zhe, AU - Gomez-Pinilla,Fernando, PY - 2004/4/14/pubmed PY - 2004/5/25/medline PY - 2004/4/14/entrez SP - 1699 EP - 707 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 19 IS - 7 N2 - A diet high in saturated fat (HF) decreases levels of brain-derived neurotrophic factor (BDNF), to the extent that compromises neuroplasticity and cognitive function, and aggravates the outcome of brain insult. By using the antioxidant power of vitamin E, we performed studies to determine the role of oxidative stress as a mediator for the effects of BDNF on synaptic plasticity and cognition caused by consumption of the HF diet. Male adult rats were maintained on a HF diet for 2 months with or without 500 IU/kg of vitamin E. Supplementation of the HF diet with vitamin E dramatically reduced oxidative damage, normalized levels of BDNF, synapsin I and cyclic AMP-response element-binding protein (CREB), caused by the consumption of the HF diet. In addition, vitamin E supplementation preserved the process of activation of synapsin I and CREB, and reversed the HF-impaired cognitive function. It is known that BDNF facilitates the synapse by modulating synapsin I and CREB, which have been implicated in synaptic plasticity associated to learning and memory. These results show that oxidative stress can interact with the BDNF system to modulate synaptic plasticity and cognitive function. Therefore, studies appear to reveal a mechanism by which events classically related to the maintenance of energy balance of the cell, such as oxidative stress, can interact with molecular events that modulate neuronal and behavioural plasticity. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/15078544/The_interplay_between_oxidative_stress_and_brain_derived_neurotrophic_factor_modulates_the_outcome_of_a_saturated_fat_diet_on_synaptic_plasticity_and_cognition_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2004&volume=19&issue=7&spage=1699 DB - PRIME DP - Unbound Medicine ER -