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[Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and the pathogenesis of pregnancy-induced hypertension syndrome].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Apr; 21(2):173-5.ZY

Abstract

OBJECTIVE

To investigate the relationship between a single nucleotide insertion/deletion(4G/5G) polymorphism located in the promoter region of the plasminogen activator inhibitor-1(PAI-1) gene and the pathogenesis of pregnancy-induced hypertension syndrome(PIHs).

METHODS

The 4G/5G polymorphism of PAI-1 gene in 171 PIHs patients (PIHs group) and that in 193 normal pregnant women (control group) were detected by a combination of polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

(1)The genotype frequencies of PAI-1 gene in PIHs group were 47.4% for 4G/4G, 41.5% for 4G/5G, and 11.1% for 5G/5G. The 4G/4G genotype and 4G allele frequencies of PAI-1 gene(47.4% and 0.681) for PIHs patients were higher than those (21.2% and 0.495) for normal controls respectively (P<0.001). (2)Both the 4G/4G genotype and the 4G allele of PAI-1 gene occurred more frequently in the severe PIHs group(61.3% and 0.758) than those (35.8% and 0.623) in the mild PIHs group respectively (P<0.001). However, there were no significant differences between those in mild group (35.8% and 0.623) and moderate group(42.8% and 0.625) respectively. (3) The 4G/4G genotype was significantly associated with PIHs (OR=3.34, 95%CI: 2.14-5.22).

CONCLUSION

These findings suggested that PAI-1 gene polymorphism may be a susceptible factor to the pathogenesis of PIHs and the 4G/4G genotype may be one of the major risk factors for PIHs in pregnant women.

Authors+Show Affiliations

Guan LX
Department of Genetics, Weifang People's Hospital, Weifang, Shandong, 261041 PR China. guan373@WF-public.sd.cninfo.net
Du XY
No affiliation info available
Wang JX
No affiliation info available
Wang RL
No affiliation info available
Wu ZL
No affiliation info available
Jiang H
No affiliation info available

MeSH

AdultFemaleGene FrequencyGenotypeHumansHypertensionPlasminogen Activator Inhibitor 1Polymorphism, GeneticPregnancyPregnancy Complications, Cardiovascular

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15079805

Citation

Guan, Li-xue, et al. "[Relationship Between the 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene and the Pathogenesis of Pregnancy-induced Hypertension Syndrome]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 21, no. 2, 2004, pp. 173-5.
Guan LX, Du XY, Wang JX, et al. [Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and the pathogenesis of pregnancy-induced hypertension syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004;21(2):173-5.
Guan, L. X., Du, X. Y., Wang, J. X., Wang, R. L., Wu, Z. L., & Jiang, H. (2004). [Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and the pathogenesis of pregnancy-induced hypertension syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 21(2), 173-5.
Guan LX, et al. [Relationship Between the 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene and the Pathogenesis of Pregnancy-induced Hypertension Syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004;21(2):173-5. PubMed PMID: 15079805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and the pathogenesis of pregnancy-induced hypertension syndrome]. AU - Guan,Li-xue, AU - Du,Xin-ying, AU - Wang,Jing-xian, AU - Wang,Rui-li, AU - Wu,Zhen-lan, AU - Jiang,Hong, PY - 2004/4/14/pubmed PY - 2004/6/16/medline PY - 2004/4/14/entrez SP - 173 EP - 5 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 21 IS - 2 N2 - OBJECTIVE: To investigate the relationship between a single nucleotide insertion/deletion(4G/5G) polymorphism located in the promoter region of the plasminogen activator inhibitor-1(PAI-1) gene and the pathogenesis of pregnancy-induced hypertension syndrome(PIHs). METHODS: The 4G/5G polymorphism of PAI-1 gene in 171 PIHs patients (PIHs group) and that in 193 normal pregnant women (control group) were detected by a combination of polymerase chain reaction-restriction fragment length polymorphism. RESULTS: (1)The genotype frequencies of PAI-1 gene in PIHs group were 47.4% for 4G/4G, 41.5% for 4G/5G, and 11.1% for 5G/5G. The 4G/4G genotype and 4G allele frequencies of PAI-1 gene(47.4% and 0.681) for PIHs patients were higher than those (21.2% and 0.495) for normal controls respectively (P<0.001). (2)Both the 4G/4G genotype and the 4G allele of PAI-1 gene occurred more frequently in the severe PIHs group(61.3% and 0.758) than those (35.8% and 0.623) in the mild PIHs group respectively (P<0.001). However, there were no significant differences between those in mild group (35.8% and 0.623) and moderate group(42.8% and 0.625) respectively. (3) The 4G/4G genotype was significantly associated with PIHs (OR=3.34, 95%CI: 2.14-5.22). CONCLUSION: These findings suggested that PAI-1 gene polymorphism may be a susceptible factor to the pathogenesis of PIHs and the 4G/4G genotype may be one of the major risk factors for PIHs in pregnant women. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/15079805/[Relationship_between_the_4G/5G_polymorphism_of_the_plasminogen_activator_inhibitor_1_gene_and_the_pathogenesis_of_pregnancy_induced_hypertension_syndrome]_ DB - PRIME DP - Unbound Medicine ER -