Tags

Type your tag names separated by a space and hit enter

Exercise induces BDNF and synapsin I to specific hippocampal subfields.
J Neurosci Res. 2004 May 01; 76(3):356-62.JN

Abstract

To assess the relationship between brain-derived neurotrophic factor (BDNF) and synapsin I in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of BDNF through its tyrosine kinase (Trk) receptor and subsequently measure the mRNA levels of synapsin I, using real-time TaqMan RT-PCR for RNA quantification. After establishing a causal link between BDNF and exercise-induced synapsin I mRNA levels, we studied the exercise-induced distribution of BDNF and synapsin I in the rodent hippocampus. Quantitative immunohistochemical analysis revealed increases of BDNF and synapsin I in CA3 stratum lucidum and dentate gyrus, and synapsin I alone in CA1 stratum radiatum and stratum laconosum moleculare. These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF.

Authors+Show Affiliations

Department of Physiological Science, UCLA, Los Angeles, California 90095, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15079864

Citation

Vaynman, Shoshanna, et al. "Exercise Induces BDNF and Synapsin I to Specific Hippocampal Subfields." Journal of Neuroscience Research, vol. 76, no. 3, 2004, pp. 356-62.
Vaynman S, Ying Z, Gómez-Pinilla F. Exercise induces BDNF and synapsin I to specific hippocampal subfields. J Neurosci Res. 2004;76(3):356-62.
Vaynman, S., Ying, Z., & Gómez-Pinilla, F. (2004). Exercise induces BDNF and synapsin I to specific hippocampal subfields. Journal of Neuroscience Research, 76(3), 356-62.
Vaynman S, Ying Z, Gómez-Pinilla F. Exercise Induces BDNF and Synapsin I to Specific Hippocampal Subfields. J Neurosci Res. 2004 May 1;76(3):356-62. PubMed PMID: 15079864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise induces BDNF and synapsin I to specific hippocampal subfields. AU - Vaynman,Shoshanna, AU - Ying,Zhe, AU - Gómez-Pinilla,Fernando, PY - 2004/4/14/pubmed PY - 2004/7/30/medline PY - 2004/4/14/entrez SP - 356 EP - 62 JF - Journal of neuroscience research JO - J. Neurosci. Res. VL - 76 IS - 3 N2 - To assess the relationship between brain-derived neurotrophic factor (BDNF) and synapsin I in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of BDNF through its tyrosine kinase (Trk) receptor and subsequently measure the mRNA levels of synapsin I, using real-time TaqMan RT-PCR for RNA quantification. After establishing a causal link between BDNF and exercise-induced synapsin I mRNA levels, we studied the exercise-induced distribution of BDNF and synapsin I in the rodent hippocampus. Quantitative immunohistochemical analysis revealed increases of BDNF and synapsin I in CA3 stratum lucidum and dentate gyrus, and synapsin I alone in CA1 stratum radiatum and stratum laconosum moleculare. These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/15079864/Exercise_induces_BDNF_and_synapsin_I_to_specific_hippocampal_subfields_ L2 - https://doi.org/10.1002/jnr.20077 DB - PRIME DP - Unbound Medicine ER -