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Plasma levels of tumor necrosis factor-alpha correlate with the six-minute walk test results in patients with mild to moderate heart failure.
Ital Heart J. 2004 Jan; 5(1):48-52.IH

Abstract

BACKGROUND

The plasma levels of brain natriuretic peptide, tumor necrosis factor-alpha, big endothelin-1 and cardiac troponins have been reported to correlate with the severity of heart failure.

METHODS

In a single population of 80 outpatients with mild to moderate chronic heart failure the correlation between the patient's functional capacity, as evaluated at a 6-min walk test, the clinical parameters and plasma levels of brain natriuretic peptide, tumor necrosis factor-alpha, big endothelin-1 and cardiac troponins was evaluated.

RESULTS

A significant inverse correlation was found with the patient's age (p < 0.0001), NYHA functional class (p < 0.0001), left ventricular dysfunction etiology (ischemic vs dilated cardiomyopathy, p < 0.0005), heart rate (p < 0.05), plasma levels of brain natriuretic peptide (p < 0.05) and of tumor necrosis factor-alpha (p < 0.0005). At multiple regression analysis a correlation was found between the 6-min walk test results and the patient's age (p < 0.05), NYHA functional class (p < 0.01), left ventricular dysfunction etiology (ischemic vs dilated cardiomyopathy, p < 0.05) and tumor necrosis factor-alpha plasma levels (p < 0.05).

CONCLUSIONS

In our patients with mild to moderate heart failure, a significant correlation was found between the results of the 6-min walk test and only the plasma concentrations of tumor necrosis factor-alpha among the laboratory parameters analyzed in this study.

Authors+Show Affiliations

Department of Cardiology, University of Padua Medical School, Italy. giovanni.boffa@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

15080581

Citation

Boffa, Giovanni Maria, et al. "Plasma Levels of Tumor Necrosis Factor-alpha Correlate With the Six-minute Walk Test Results in Patients With Mild to Moderate Heart Failure." Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, vol. 5, no. 1, 2004, pp. 48-52.
Boffa GM, Zaninotto M, Nalli C, et al. Plasma levels of tumor necrosis factor-alpha correlate with the six-minute walk test results in patients with mild to moderate heart failure. Ital Heart J. 2004;5(1):48-52.
Boffa, G. M., Zaninotto, M., Nalli, C., Forni, M., Tiso, E., Razzolini, R., & Plebani, M. (2004). Plasma levels of tumor necrosis factor-alpha correlate with the six-minute walk test results in patients with mild to moderate heart failure. Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, 5(1), 48-52.
Boffa GM, et al. Plasma Levels of Tumor Necrosis Factor-alpha Correlate With the Six-minute Walk Test Results in Patients With Mild to Moderate Heart Failure. Ital Heart J. 2004;5(1):48-52. PubMed PMID: 15080581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of tumor necrosis factor-alpha correlate with the six-minute walk test results in patients with mild to moderate heart failure. AU - Boffa,Giovanni Maria, AU - Zaninotto,Martina, AU - Nalli,Chiara, AU - Forni,Massimo, AU - Tiso,Enrico, AU - Razzolini,Renato, AU - Plebani,Mario, PY - 2004/4/15/pubmed PY - 2004/11/9/medline PY - 2004/4/15/entrez SP - 48 EP - 52 JF - Italian heart journal : official journal of the Italian Federation of Cardiology JO - Ital Heart J VL - 5 IS - 1 N2 - BACKGROUND: The plasma levels of brain natriuretic peptide, tumor necrosis factor-alpha, big endothelin-1 and cardiac troponins have been reported to correlate with the severity of heart failure. METHODS: In a single population of 80 outpatients with mild to moderate chronic heart failure the correlation between the patient's functional capacity, as evaluated at a 6-min walk test, the clinical parameters and plasma levels of brain natriuretic peptide, tumor necrosis factor-alpha, big endothelin-1 and cardiac troponins was evaluated. RESULTS: A significant inverse correlation was found with the patient's age (p < 0.0001), NYHA functional class (p < 0.0001), left ventricular dysfunction etiology (ischemic vs dilated cardiomyopathy, p < 0.0005), heart rate (p < 0.05), plasma levels of brain natriuretic peptide (p < 0.05) and of tumor necrosis factor-alpha (p < 0.0005). At multiple regression analysis a correlation was found between the 6-min walk test results and the patient's age (p < 0.05), NYHA functional class (p < 0.01), left ventricular dysfunction etiology (ischemic vs dilated cardiomyopathy, p < 0.05) and tumor necrosis factor-alpha plasma levels (p < 0.05). CONCLUSIONS: In our patients with mild to moderate heart failure, a significant correlation was found between the results of the 6-min walk test and only the plasma concentrations of tumor necrosis factor-alpha among the laboratory parameters analyzed in this study. SN - 1129-471X UR - https://www.unboundmedicine.com/medline/citation/15080581/Plasma_levels_of_tumor_necrosis_factor_alpha_correlate_with_the_six_minute_walk_test_results_in_patients_with_mild_to_moderate_heart_failure_ L2 - http://www.diseaseinfosearch.org/result/3258 DB - PRIME DP - Unbound Medicine ER -