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The polycystic ovary syndrome per se is not associated with increased chronic inflammation.
Eur J Endocrinol. 2004 Apr; 150(4):525-32.EJ

Abstract

OBJECTIVE

The syndrome of polycystic ovaries (PCOS) is a known risk factor for type 2 diabetes. It is not known, however, whether the increase in diabetes risk is related to endocrine abnormalities associated with PCOS such as hyperandrogenemia, or whether it is a consequence of the anthropometric or metabolic alterations frequently observed in PCOS women.

DESIGN

Since markers of inflammation are supposed to predict type 2 diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) in combination with parameters of obesity, insulin resistance and hyperandrogenism were determined in 57 PCOS women and in 20 age-matched healthy controls. In addition, the C-174G IL-6 promoter polymorphism was analyzed as a determinant in influencing IL-6, obesity, and androgen levels in women.

RESULTS

Neither CRP nor IL-6 were significantly elevated in lean or obese PCOS women compared with age-matched lean or obese controls. In PCOS patients, variables of body composition (body mass index (BMI), waist to hip ratio, dual-energy X-ray-absorptiometry fat mass) and of insulin resistance were correlated with IL-6 or CRP, while parameters of hyperandogenism were not. Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women. No association of IL-6 or BMI to a certain genotype at C-174G could be demonstrated in 50 PCOS patients. The heterozygous GC genotype, however, was associated with lower androstendione levels. Metformin treatment of 9 obese, insulin-resistant PCOS patients over a period of 6 months caused a significant decrease in body weight, body fat mass and total testosterone, but showed no significant decline in IL-6 or CRP concentrations.

CONCLUSIONS

In PCOS women, plasma levels of IL-6 and CRP were not increased when compared with age- and BMI-matched controls. BMI was, however, the parameter most strongly related to IL-6 and CRP in PCOS; thus PCOS-related endocrine abnormalities do not appear to activate inflammatory parameters thereby enhancing the risk of diabetes. In PCOS, the type 2 diabetes risk may, therefore, be confined to those with obesity and/or metabolic alterations rather than affecting all women suffering from the syndrome.

Authors+Show Affiliations

Möhlig M
Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam-Rehbruecke, Germany.
Spranger J
No affiliation info available
Osterhoff M
No affiliation info available
Ristow M
No affiliation info available
Pfeiffer AF
No affiliation info available
Schill T
No affiliation info available
Schlösser HW
No affiliation info available
Brabant G
No affiliation info available
Schöfl C
No affiliation info available

MeSH

AdultC-Reactive ProteinChronic DiseaseDiabetes MellitusDiabetes Mellitus, Type 2FemaleHumansInflammationInsulin ResistanceInterleukin-6ObesityPolycystic Ovary SyndromePolymorphism, GeneticPromoter Regions, GeneticRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15080783

Citation

Möhlig, Matthias, et al. "The Polycystic Ovary Syndrome Per Se Is Not Associated With Increased Chronic Inflammation." European Journal of Endocrinology, vol. 150, no. 4, 2004, pp. 525-32.
Möhlig M, Spranger J, Osterhoff M, et al. The polycystic ovary syndrome per se is not associated with increased chronic inflammation. Eur J Endocrinol. 2004;150(4):525-32.
Möhlig, M., Spranger, J., Osterhoff, M., Ristow, M., Pfeiffer, A. F., Schill, T., Schlösser, H. W., Brabant, G., & Schöfl, C. (2004). The polycystic ovary syndrome per se is not associated with increased chronic inflammation. European Journal of Endocrinology, 150(4), 525-32.
Möhlig M, et al. The Polycystic Ovary Syndrome Per Se Is Not Associated With Increased Chronic Inflammation. Eur J Endocrinol. 2004;150(4):525-32. PubMed PMID: 15080783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The polycystic ovary syndrome per se is not associated with increased chronic inflammation. AU - Möhlig,Matthias, AU - Spranger,Joachim, AU - Osterhoff,Martin, AU - Ristow,Michael, AU - Pfeiffer,Andreas F H, AU - Schill,Thilo, AU - Schlösser,Hans W, AU - Brabant,Georg, AU - Schöfl,Christof, PY - 2004/4/15/pubmed PY - 2004/6/24/medline PY - 2004/4/15/entrez SP - 525 EP - 32 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 150 IS - 4 N2 - OBJECTIVE: The syndrome of polycystic ovaries (PCOS) is a known risk factor for type 2 diabetes. It is not known, however, whether the increase in diabetes risk is related to endocrine abnormalities associated with PCOS such as hyperandrogenemia, or whether it is a consequence of the anthropometric or metabolic alterations frequently observed in PCOS women. DESIGN: Since markers of inflammation are supposed to predict type 2 diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) in combination with parameters of obesity, insulin resistance and hyperandrogenism were determined in 57 PCOS women and in 20 age-matched healthy controls. In addition, the C-174G IL-6 promoter polymorphism was analyzed as a determinant in influencing IL-6, obesity, and androgen levels in women. RESULTS: Neither CRP nor IL-6 were significantly elevated in lean or obese PCOS women compared with age-matched lean or obese controls. In PCOS patients, variables of body composition (body mass index (BMI), waist to hip ratio, dual-energy X-ray-absorptiometry fat mass) and of insulin resistance were correlated with IL-6 or CRP, while parameters of hyperandogenism were not. Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women. No association of IL-6 or BMI to a certain genotype at C-174G could be demonstrated in 50 PCOS patients. The heterozygous GC genotype, however, was associated with lower androstendione levels. Metformin treatment of 9 obese, insulin-resistant PCOS patients over a period of 6 months caused a significant decrease in body weight, body fat mass and total testosterone, but showed no significant decline in IL-6 or CRP concentrations. CONCLUSIONS: In PCOS women, plasma levels of IL-6 and CRP were not increased when compared with age- and BMI-matched controls. BMI was, however, the parameter most strongly related to IL-6 and CRP in PCOS; thus PCOS-related endocrine abnormalities do not appear to activate inflammatory parameters thereby enhancing the risk of diabetes. In PCOS, the type 2 diabetes risk may, therefore, be confined to those with obesity and/or metabolic alterations rather than affecting all women suffering from the syndrome. SN - 0804-4643 UR - https://www.unboundmedicine.com/medline/citation/15080783/The_polycystic_ovary_syndrome_per_se_is_not_associated_with_increased_chronic_inflammation_ DB - PRIME DP - Unbound Medicine ER -